3.4.23.26: Rhodotorulapepsin

This is an abbreviated version!
For detailed information about Rhodotorulapepsin, go to the full flat file.

Reaction

Specificity similar to that of pepsin A. Cleaves Z-Lys-/-Ala-Ala-Ala and activates trypsinogen =

Synonyms

Cladosporium acid protease, Cladosporium acid proteinase, EC 3.4.23.6, EC 3.4.4.17, EC 3.4.99.15, extracellular acid protease, Paecilomyces proteinase, Proteinase, Cladosporium aspartic, Proteinase, Paecilomyces, Proteinase, Rhodotorula glutinis aspartic, Proteinase, Rhodotorula glutinis aspartic, II, Rhodotorula acid proteinase, Rhodotorula aspartic proteinase, Rhodotorula glutinis acid proteinase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.26 Rhodotorulapepsin

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Results	in table
1	CAS Registry Number
4	Crystallization (Commentary)
1	General Stability
24	Inhibitors
4	Localization
4	Molecular Weight [Da]
33	Organism
5	pH Optimum
4	pH Range
4	pH Stability
1	pI Value
4	Purification (Commentary)
1	Reaction
1	Reaction Type
19	Reference
3	Specific Activity [micromol/min/mg]
42	Substrates and Products (Substrate)
2	Subunits
15	Synonyms
3	Temperature Optimum [°C]
3	Temperature Range [°C]
6	Temperature Stability [°C]

Substrates Products

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of the Enzyme Summary Page.

Substrates Products on EC 3.4.23.26 - Rhodotorulapepsin

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser + H2O

?

2 entries

azocasein + H2O

?

2 entries

Benzyloxycarbonyl-Glu-Tyr + H2O

Benzyloxycarbonyl-Glu + Tyr

4 entries

Benzyloxycarbonyl-Gly-Phe + H2O

Benzyloxycarbonyl-Gly + Phe

4 entries

Benzyloxycarbonyl-Phe-Tyr + H2O

Benzyloxycarbonyl-Phe + Tyr

4 entries

casein + H2O

?

4 entries

Copoly-L-Leu-L-Lys*HBr + H2O

?

2 entries

Copoly-L-Leu-L-Orn-NH2*HBr + H2O

?

4 entries

DRVYIHPFHLLVYS + H2O

DRVY + IHPFHLL + VYS

2 entries

Gly-Leu-Tyr + H2O

Gly-Leu + Tyr

4 entries

Hemoglobin + H2O

?

4 entries

Z-Lys-Ala-Ala-Ala + H2O

Z-Lys + Ala-Ala-Ala

2 entries

Z-Lys-Leu-Ala-Ala + H2O

Z-Lys + Leu-Ala-Ala

2 entries

additional information

?

-

2 entries

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser + H2O

?

Rhodotorula glutinis

-

preferential cleavage of: Tyr-Ile and Leu-Val, at a lower rate: Val-Tyr and Leu-Leu

30559

-

-

?

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser + H2O

?

Rhodotorula glutinis K-24

-

preferential cleavage of: Tyr-Ile and Leu-Val, at a lower rate: Val-Tyr and Leu-Leu

30559

-

-

?

azocasein + H2O

?

Rhodotorula mucilaginosa

-

-

753717

-

-

?

azocasein + H2O

?

Rhodotorula mucilaginosa L7

-

-

753717

-

-

?

Benzyloxycarbonyl-Glu-Tyr + H2O

Benzyloxycarbonyl-Glu + Tyr

Cladosporium sp.

-

-

30718

-

-

?

Benzyloxycarbonyl-Glu-Tyr + H2O

Benzyloxycarbonyl-Glu + Tyr

Cladosporium sp. No. 45-2

-

-

30718

-

-

?

Benzyloxycarbonyl-Glu-Tyr + H2O

Benzyloxycarbonyl-Glu + Tyr

Rhodotorula glutinis

-

-

30716

-

30716

?

Benzyloxycarbonyl-Glu-Tyr + H2O

Benzyloxycarbonyl-Glu + Tyr

Rhodotorula glutinis K-24

-

-

30716

-

30716

?

Benzyloxycarbonyl-Gly-Phe + H2O

Benzyloxycarbonyl-Gly + Phe

Cladosporium sp.

-

-

30718

-

-

?

Benzyloxycarbonyl-Gly-Phe + H2O

Benzyloxycarbonyl-Gly + Phe

Cladosporium sp. No. 45-2

-

-

30718

-

-

?

Benzyloxycarbonyl-Gly-Phe + H2O

Benzyloxycarbonyl-Gly + Phe

Rhodotorula glutinis

-

-

30716

-

30716

?

Benzyloxycarbonyl-Gly-Phe + H2O

Benzyloxycarbonyl-Gly + Phe

Rhodotorula glutinis K-24

-

-

30716

-

30716

?

Benzyloxycarbonyl-Phe-Tyr + H2O

Benzyloxycarbonyl-Phe + Tyr

Cladosporium sp.

-

-

30718

-

-

?

Benzyloxycarbonyl-Phe-Tyr + H2O

Benzyloxycarbonyl-Phe + Tyr

Cladosporium sp. No. 45-2

-

-

30718

-

-

?

Benzyloxycarbonyl-Phe-Tyr + H2O

Benzyloxycarbonyl-Phe + Tyr

Rhodotorula glutinis

-

-

30716

-

30716

?

Benzyloxycarbonyl-Phe-Tyr + H2O

Benzyloxycarbonyl-Phe + Tyr

Rhodotorula glutinis K-24

-

-

30716

-

30716

?

casein + H2O

?

Cladosporium sp.

-

-

30715

-

-

?

casein + H2O

?

Cladosporium sp. No. 45-2

-

-

30715

-

-

?

casein + H2O

?

Rhodotorula glutinis

-

high activity

668791

-

-

?

casein + H2O

?

Rhodotorula glutinis K-24

-

high activity

668791

-

-

?

Copoly-L-Leu-L-Lys*HBr + H2O

?

Cladosporium sp.

-

1:1, DPn: 50

30718

-

-

?

Copoly-L-Leu-L-Lys*HBr + H2O

?

Rhodotorula glutinis

-

1:1, DPn: 50

30716

-

-

?

Copoly-L-Leu-L-Orn-NH2*HBr + H2O

?

Cladosporium sp.

-

1:1, DPn: 50

30718

-

-

?

Copoly-L-Leu-L-Orn-NH2*HBr + H2O

?

Cladosporium sp. No. 45-2

-

1:1, DPn: 50

30718

-

-

?

Copoly-L-Leu-L-Orn-NH2*HBr + H2O

?

Rhodotorula glutinis

-

1:1, DPn: 50

30716

-

-

?

Copoly-L-Leu-L-Orn-NH2*HBr + H2O

?

Rhodotorula glutinis K-24

-

1:1, DPn: 50

30716

-

-

?

DRVYIHPFHLLVYS + H2O

DRVY + IHPFHLL + VYS

Rhodotorula glutinis

-

tetradecapaptide renin substrate, cleavage pattern, overview

668791

-

-

?

DRVYIHPFHLLVYS + H2O

DRVY + IHPFHLL + VYS

Rhodotorula glutinis K-24

-

tetradecapaptide renin substrate, cleavage pattern, overview

668791

-

-

?

Gly-Leu-Tyr + H2O

Gly-Leu + Tyr

Cladosporium sp.

-

-

30718

-

-

?

Gly-Leu-Tyr + H2O

Gly-Leu + Tyr

Cladosporium sp. No. 45-2

-

-

30718

-

-

?

Gly-Leu-Tyr + H2O

Gly-Leu + Tyr

Rhodotorula glutinis

-

-

30716

-

30716

?

Gly-Leu-Tyr + H2O

Gly-Leu + Tyr

Rhodotorula glutinis K-24

-

-

30716

-

30716

?

Hemoglobin + H2O

?

Cladosporium sp.

-

-

30715

-

-

?

Hemoglobin + H2O

?

Cladosporium sp. No. 45-2

-

-

30715

-

-

?

Hemoglobin + H2O

?

Rhodotorula glutinis

-

-

30717

-

-

?

Hemoglobin + H2O

?

Rhodotorula glutinis K-24

-

-

30717

-

-

?

Z-Lys-Ala-Ala-Ala + H2O

Z-Lys + Ala-Ala-Ala

Rhodotorula glutinis

-

-

668791

-

-

?

Z-Lys-Ala-Ala-Ala + H2O

Z-Lys + Ala-Ala-Ala

Rhodotorula glutinis K-24

-

-

668791

-

-

?

Z-Lys-Leu-Ala-Ala + H2O

Z-Lys + Leu-Ala-Ala

Rhodotorula glutinis

-

-

668791

-

-

?

Z-Lys-Leu-Ala-Ala + H2O

Z-Lys + Leu-Ala-Ala

Rhodotorula glutinis K-24

-

-

668791

-

-

?

additional information

?

-

Rhodotorula glutinis

-

substrate specificity, overview, high activity with increasing chain length and Ala at the N-terminal side of the scissile bond, no activity with Z-Lys-Ala-Ala

668791

-

-

?

additional information

?

-

Rhodotorula glutinis K-24

-

substrate specificity, overview, high activity with increasing chain length and Ala at the N-terminal side of the scissile bond, no activity with Z-Lys-Ala-Ala

668791

-

-

?