3.4.23.25: saccharopepsin

This is an abbreviated version!
For detailed information about saccharopepsin, go to the full flat file.

Reaction

Hydrolysis of proteins with broad specificity for peptide bonds. Cleaves -Leu-Leu-/-Val-Tyr bond in a synthetic substrate. Does not act on esters of Tyr or Arg =

Synonyms

Acid protease, Aspartate protease, Aspartic proteinase, Aspartic proteinase yscA, EC 3.4.23.6, EC 3.4.23.8, EC 3.4.4.17, Pep4, PEP4 gene product, Pep4p, Pep4p vacuolar proteinase, pepsin-like aspartic proteinase, PRA, preproPrA, proPrA, Protease A, Proteinase A, proteinase A precursor, Proteinase yscA, Proteinase, yeast A, proteinase-A, pseudo-proteinase A, Saccharomyces aspartic proteinase, Saccharomyces cerevisiae aspartic proteinase A, saccharopepsin, vacuolar aspartic proteinase, yeast aspartic proteinase A, Yeast endopeptidase A, yeast proteinase, Yeast proteinase A

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.25 saccharopepsin

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Results	in table
2	Activating Compound
18	AA Sequence
9	Application
1	CAS Registry Number
5	Cloned(Commentary)
6	Crystallization (Commentary)
3	Expression
2	General Information
3	General Stability
1	IC50 Value
50	Inhibitors
47	Ki Value [mM]
39	KM Value [mM]
21	Localization
18	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
76	Organism
12	PDB ID
14	pH Optimum
4	pH Range
4	pH Stability
9	Posttranslational Modification
5	Protein Variants
13	Purification (Commentary)
3	Reaction
1	Reaction Type
43	Reference
1	Source Tissue
4	Specific Activity [micromol/min/mg]
2	Storage Stability
115	Substrates and Products (Substrate)
15	Subunits
75	Synonyms
2	Temperature Optimum [°C]
3	Temperature Stability [°C]
40	Turnover Number [1/s]

Synonyms

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Synonyms on EC 3.4.23.25 - saccharopepsin

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

Acid protease

Aspergillus phoenicis

-

-

653778

Aspartate protease

-

-

-

-

Aspartic proteinase

2 entries

Aspartic proteinase yscA

-

-

-

-

EC 3.4.23.6

-

-

formerly

-

EC 3.4.23.8

-

-

formerly

-

EC 3.4.4.17

-

-

formerly, part transferred

-

Pep4

3 entries

PEP4 gene product

3 entries

Pep4p

Saccharomyces cerevisiae

-

-

688855

Pep4p vacuolar proteinase

Saccharomyces cerevisiae

-

-

688855

pepsin-like aspartic proteinase

Saccharomyces cerevisiae

P07267

-

683009

PRA

8 entries

preproPrA

Saccharomyces cerevisiae

P07267

inactive non-glycosylated precursor

683009

proPrA

Saccharomyces cerevisiae

P07267

inactive glycosylated precursor

683009

Protease A

3 entries

Proteinase A

6 entries

proteinase A precursor

Saccharomyces cerevisiae

P07267

inactive, maturation into active enzyme required proteinase B activity, 405 residues long precursor and 329 residues for the mature protein (77-405)

683009

Proteinase yscA

-

-

-

-

Proteinase, yeast A

-

-

-

-

proteinase-A

Saccharomyces cerevisiae

-

-

649129

pseudo-proteinase A

Saccharomyces cerevisiae

P07267

active form of the enzyme resulting from autoactivation

683009

Saccharomyces aspartic proteinase

-

-

-

-

Saccharomyces cerevisiae aspartic proteinase A

-

-

-

-

saccharopepsin

Saccharomyces cerevisiae

P07267

-

698459

vacuolar aspartic proteinase

Saccharomyces cerevisiae

-

-

649129, 652836

yeast aspartic proteinase A

Saccharomyces cerevisiae

P07267

-

698459

Yeast endopeptidase A

-

-

-

-

yeast proteinase

Saccharomyces cerevisiae

-

-

652836

Yeast proteinase A

2 entries

Aspartic proteinase

Saccharomyces cerevisiae

-

-

649129, 650379, 652130, 653309

Aspartic proteinase

Saccharomyces cerevisiae

P07267

-

649600

Pep4

Saccharomyces cerevisiae

-

-

683085, 717794, 718128, 754333, 755660

Pep4

Saccharomyces cerevisiae MT8-1

-

-

-

Pep4

Saccharomyces cerevisiae W303-1A

-

-

-

PEP4 gene product

Saccharomyces cerevisiae

-

-

686781, 688855

PEP4 gene product

Saccharomyces cerevisiae

-

PEP4 gene encodes the inactive preproenzyme

683085

PEP4 gene product

Saccharomyces cerevisiae MT8-1

-

PEP4 gene encodes the inactive preproenzyme

-

PRA

-

-

-

-

PRA

Debaryomyces hansenii

-

-

683560

PRA

Debaryomyces hansenii CECT 12487

-

-

-

PRA

Debaryomyces hansenii CECT12487

-

-

-

PRA

Saccharomyces cerevisiae

-

-

651749, 683085, 686781, 754333, 754336, 755660

PRA

Saccharomyces cerevisiae

P07267

-

683009

PRA

Saccharomyces cerevisiae MT8-1

-

-

-

PRA

Saccharomyces cerevisiae W303-1A

-

-

-

Protease A

Debaryomyces hansenii

-

aspartic protease

683560

Protease A

Debaryomyces hansenii CECT 12487

-

aspartic protease

-

Protease A

Debaryomyces hansenii CECT12487

-

aspartic protease

-

Proteinase A

-

-

-

-

Proteinase A

Saccharomyces cerevisiae

-

-

651749, 652130, 652836, 653309, 683085, 686781, 688855, 754333, 754336, 754358, 755660

Proteinase A

Saccharomyces cerevisiae

-

use of recommended name should be favored

687670

Proteinase A

Saccharomyces cerevisiae

P07267

-

649600, 683009

Proteinase A

Saccharomyces cerevisiae MT8-1

-

-

-

Proteinase A

Saccharomyces cerevisiae W303-1A

-

-

-

Yeast proteinase A

-

-

-

-

Yeast proteinase A

Saccharomyces cerevisiae

-

-

650379