3.4.23.25: saccharopepsin
This is an abbreviated version!
For detailed information about saccharopepsin, go to the full flat file.
Word Map on EC 3.4.23.25
Reaction
Hydrolysis of proteins with broad specificity for peptide bonds. Cleaves -Leu-Leu-/-Val-Tyr bond in a synthetic substrate. Does not act on esters of Tyr or Arg =
Synonyms
Acid protease, Aspartate protease, Aspartic proteinase, Aspartic proteinase yscA, EC 3.4.23.6, EC 3.4.23.8, EC 3.4.4.17, Pep4, PEP4 gene product, Pep4p, Pep4p vacuolar proteinase, pepsin-like aspartic proteinase, PRA, preproPrA, proPrA, Protease A, Proteinase A, proteinase A precursor, Proteinase yscA, Proteinase, yeast A, proteinase-A, pseudo-proteinase A, Saccharomyces aspartic proteinase, Saccharomyces cerevisiae aspartic proteinase A, saccharopepsin, vacuolar aspartic proteinase, yeast aspartic proteinase A, Yeast endopeptidase A, yeast proteinase, Yeast proteinase A
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Reference on EC 3.4.23.25 - saccharopepsin
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ammerer, G.; Hunter, C.P.; Rothman, J.H.; Saari, G.C.; Valls, L.A.; Stevens, T.H.
PEP4 gene of Saccharomyces cerevisiae encodes proteinase A, a vacuolar enzyme required for processing of vacuolar precursors
Mol. Cell. Biol.
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2490-2499
1986
Saccharomyces cerevisiae
Meussendoerffer, F.; Tortora, P.; Holzer, H.
Purification and properties of proteinase A from yeast
J. Biol. Chem.
255
12087-12093
1980
Saccharomyces cerevisiae
Mechler, B.; Muller, M.; Muller, H.; Meussendoerffer, F.; Wolf, D.H.
In vivo biosynthesis of the vacuolar proteinases A and B in the yeast Saccharomyces cerevisiae
J. Biol. Chem.
257
11203-11206
1982
Saccharomyces cerevisiae
Rothman, J.H.; Hunter, C.P.; Valls, L.A.; Stevens, T.H.
Overproduction-induced mislocalization of a yeast vacuolar protein allows isolation of its structural gene
Proc. Natl. Acad. Sci. USA
83
3248-3252
1986
Saccharomyces cerevisiae
Mechler, B.; Wolf, D.H.
Analysis of proteinase A function in yeast
Eur. J. Biochem.
121
47-52
1981
Saccharomyces cerevisiae
Dreyer, T.; Valler, M.J.; Kay, J.; Charlton, P.; Dunn, B.M.
The selectivity of action of the aspartic-proteinase inhibitor IA3 from yeast (Saccharomyces cerevisiae)
Biochem. J.
231
777-779
1985
Saccharomyces cerevisiae
Dreyer, T.; Svendsen, I.; Ottesen, M.
Partial primary structure and substance specificity of proteinase A from Saccharomyces cerevisiae
Biochem. Soc. Trans.
13
1142-1143
1985
Saccharomyces cerevisiae
-
Jusic, M.; Hinze, H.; Holzer, H.
Inactivation of yeast enzymes by proteinase A and B and carboxypeptidase Y from yeast
Hoppe-Seyler's Z. Physiol. Chem.
357
735-740
1976
Saccharomyces cerevisiae
Huse, K.; Kopperschläger, G.; Hofmann, E.
Differences in the degradation of yeast phosphofructokinase by proteinases A and B from yeast
Biochem. J.
155
721-723
1976
Saccharomyces cerevisiae
Pedersen, J.; Biedermann, K.
Characterization of proteinase A glycoforms from recombinant Saccharomyces cerevisiae
Biotechnol. Appl. Biochem.
18
377-388
1993
Saccharomyces cerevisiae
Yokosawa, H.; Ito, H.; Murata, S.; Ishii, S.I.
Purification and fluorometric assay of proteinase A from yeast
Anal. Biochem.
134
210-215
1983
Saccharomyces cerevisiae
Badasso, M.; Wood, S.P.; Aguilar, C.; Cooper, J.B.; Blundell, T.L.
Crystallization and preliminary crystallographic characterization of aspartic proteinase-A from bakers yeast and its complexes with inhibitors
J. Mol. Biol.
232
701-703
1993
Saccharomyces cerevisiae
Faust, P.L.; Kornfeld, S.
Expression of the yeast aspartyl protease, proteinase A. Phosphorylation and binding to the mannose 6-phosphate receptor are altered by addition of cathepsin D sequences
J. Biol. Chem.
264
479-488
1989
Saccharomyces cerevisiae
Magni, G.; Natalini, P.; Santarelli, I.; Vita, A.
Bakers yeast protease A purification and enzymatic and molecular properties
Arch. Biochem. Biophys.
213
426-433
1982
Saccharomyces cerevisiae
Nowak, J.; Tsai, H.
Purification and properties of three endopeptidases from baker's yeast
Can. J. Microbiol.
35
295-303
1989
Saccharomyces cerevisiae
Dreyer, T.
Substrate specificity of proteinase yscA from saccharomyces cerevisiae
Carlsberg Res. Commun.
54
85-97
1989
Saccharomyces cerevisiae
Dreyer, T.; Halkier, B.; Svendsen, I.; Ottesen, M.
Primary structure of the aspartic proteinase A from Saccharomyces cerevisiae
Carlsberg Res. Commun.
51
27-41
1986
Saccharomyces cerevisiae
-
Badasso, M.O.; Read, J.A.; Dhanaraj, V.; Cooper, J.B.; Wood, S.P.; Blundell, T.L.; Dreyer, T.; Winther, J.
Purification, co-crystallization and preliminary X--ray analysis of the natural aspartic proteinase inhibitor IA3 complexed with saccharopepsin from Saccharomyces cerevisiae
Acta Crystallogr. Sect. D
56
915-917
2000
Saccharomyces cerevisiae
Gustchina, A.; Li, M.; Phylip, L.H.; Lees, W.E.; Kay, J.; Wlodawer, A.
An unusual orientation for Tyr75 in the active site of the aspartic proteinase from Saccharomyces cerevisiae
Biochem. Biophys. Res. Commun.
295
1020-1026
2002
Saccharomyces cerevisiae (P07267)
Cater, S.A.; Lees, W.E.; Hill, J.; Brzin, J.; Kay, J.; Phylip, L.H.
Aspartic proteinase inhibitors from tomato and potato are more potent against yeast proteinase A than cathepsin D
Biochim. Biophys. Acta
1596
76-82
2002
Saccharomyces cerevisiae
Kondo, H.; Shibano, Y.; Amachi, T.; Cronin, N.; Oda, K.; Dunn, B.M.
Substrate specificities and kinetic properties of proteinase A from the yeast Saccharomyces cerevisiae and the development of a novel substrate
J. Biochem.
124
141-147
1998
Saccharomyces cerevisiae
Phylip, L.H.; Lees, W.E.; Brownsey, B.G.; Bur, D.; Dunn, B.M.; Winther, J.R.; Gustchina, A.; Li, M.; Copeland, T.; Wlodawer, A.; Kay, J.
The potency and specificity of the interaction between the IA3 inhibitor and its target aspartic proteinase from Saccharomyces cerevisiae
J. Biol. Chem.
276
2023-2030
2001
Saccharomyces cerevisiae
Cronin, N.B.; Badasso, M.O.; Tickle, J.; Dreyer, T.; Hoover, D.J.; Rosati, R.L.; Humblet, C.C.; Lunney, E.A.; Cooper, J.B.
X-ray structures of five renin inhibitors bound to saccharopepsin: exploration of active-site specificity
J. Mol. Biol.
303
745-760
2000
Saccharomyces cerevisiae
Li, M.; Phylip, L.H.; Lees, W.E.; Winther, J.R.; Dunn, B.M.; Wlodawer, A.; Kay, J.; Gustchina, A.
The aspartic proteinase from Saccharomyces cerevisiae folds its own inhibitor into a helix
Nat. Struct. Biol.
7
113-117
2000
Saccharomyces cerevisiae
Tello-Solis, S.R.
Effect of the pH in the conformation and activity of the acid protease from Aspergillus saitoi
Protein Pept. Lett.
8
101-108
2001
Aspergillus phoenicis
-
Green, T.B.; Ganesh, O.; Perry, K.; Smith, L.; Phylip, L.H.; Logan, T.M.; Hagen, S.J.; Dunn, B.M.; Edison, A.S.
IA3, an aspartic proteinase inhibitor from Saccharomyces cerevisiae, is intrinsically unstructured in solution
Biochemistry
43
4071-4081
2004
Saccharomyces cerevisiae
Bae, J.H.; Sohn, J.H.; Rhee, S.K.; Choi, E.S.
Cloning and characterization of the Hansenula polymorpha PEP4 gene encoding proteinase A
Yeast
22
13-19
2005
Ogataea angusta (O14413)
Parr, C.L.; Keates, R.A.; Bryksa, B.C.; Ogawa, M.; Yada, R.Y.
The structure and function of Saccharomyces cerevisiae proteinase A
Yeast
24
467-480
2007
Saccharomyces cerevisiae (P07267), Saccharomyces cerevisiae
Kato, M.; Kuzuhara, Y.; Maeda, H.; Shiraga, S.; Ueda, M.
Analysis of a processing system for proteases using yeast cell surface engineering: conversion of precursor of proteinase A to active proteinase A
Appl. Microbiol. Biotechnol.
72
1229-1237
2006
Saccharomyces cerevisiae
Bolumar, T.; Sanz, Y.; Aristoy, M.C.; Toldra, F.
Purification and characterisation of proteases A and D from Debaryomyces hansenii
Int. J. Food Microbiol.
124
135-141
2008
Debaryomyces hansenii, Debaryomyces hansenii CECT12487
Guilloux-Benatier, M.; Remize, F.; Gal, L.; Guzzo, J.; Alexandre, H.
Effects of yeast proteolytic activity on Oenococcus oeni and malolactic fermentation
FEMS Microbiol. Lett.
263
183-188
2006
Saccharomyces cerevisiae
Winterburn, T.J.; Wyatt, D.M.; Phylip, L.H.; Bur, D.; Harrison, R.J.; Berry, C.; Kay, J.
Key features determining the specificity of aspartic proteinase inhibition by the helix-forming IA3 polypeptide
J. Biol. Chem.
282
6508-6516
2007
Saccharomyces cerevisiae
Marques, M.; Mojzita, D.; Amorim, M.A.; Almeida, T.; Hohmann, S.; Moradas-Ferreira, P.; Costa, V.
The Pep4p vacuolar proteinase contributes to the turnover of oxidized proteins but PEP4 overexpression is not sufficient to increase chronological lifespan in Saccharomyces cerevisiae
Microbiology
152
3595-3605
2006
Saccharomyces cerevisiae
Narayanan, R.; Ganesh, O.K.; Edison, A.S.; Hagen, S.J.
Kinetics of folding and binding of an intrinsically disordered protein: the inhibitor of yeast aspartic proteinase YPrA
J. Am. Chem. Soc.
130
11477-11485
2008
Saccharomyces cerevisiae (P07267), Saccharomyces cerevisiae
Spedale, G.; Mischerikow, N.; Heck, A.; Marc Timmers, H.; Pim Pijnappel, W.
Identification of Pep4p as the protease responsible for formation of the SAGA-related SLIK protein complex
J. Biol. Chem.
285
22793-22799
2010
Saccharomyces cerevisiae
Pereira, C.; Chaves, S.; Alves, S.; Salin, B.; Camougrand, N.; Manon, S.; Sousa, M.; Corte-Real, M.
Mitochondrial degradation in acetic acid-induced yeast apoptosis: The role of Pep4 and the ADP/ATP carrier
Mol. Microbiol.
76
1398-1410
2010
Saccharomyces cerevisiae
Chen, Y.; Song, L.; Han, Y.; Liu, M.; Gong, R.; Luo, W.; Guo, X.; Xiao, D.
Decreased proteinase A excretion by strengthening its vacuolar sorting and weakening ist constitutive secretion in Saccharomyces cerevisiae
J. Ind. Microbiol. Biotechnol.
44
149-159
2017
Saccharomyces cerevisiae, Saccharomyces cerevisiae W303-1A
Song, L.; Chen, Y.; Guo, Q.; Huang, S.; Guo, X.; Xiao, D.
Regulating the Golgi apparatus sorting of proteinase A to decrease its excretion in Saccharomyces cerevisiae
J. Ind. Microbiol. Biotechnol.
46
601-612
2019
Saccharomyces cerevisiae, Saccharomyces cerevisiae W303-1A
Dong, L.; Li, F.; Piao, Y.; Sun, D.; Zhao, R.; Li, C.; Cong, L.; Zhao, C.
Characterization of proteinase A excretion from Saccharomyces cerevisiae in high sugar stress conditions
J. Korean Soc. Appl. Biol. Chem.
58
203-208
2015
Saccharomyces cerevisiae
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