3.4.23.25: saccharopepsin
This is an abbreviated version!
For detailed information about saccharopepsin, go to the full flat file.
Reaction
Hydrolysis of proteins with broad specificity for peptide bonds. Cleaves -Leu-Leu-/-Val-Tyr bond in a synthetic substrate. Does not act on esters of Tyr or Arg
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Synonyms
Acid protease, Aspartate protease, Aspartic proteinase, Aspartic proteinase yscA, EC 3.4.23.6, EC 3.4.23.8, EC 3.4.4.17, Pep4, PEP4 gene product, Pep4p, Pep4p vacuolar proteinase, pepsin-like aspartic proteinase, PRA, preproPrA, proPrA, Protease A, Proteinase A, proteinase A precursor, Proteinase yscA, Proteinase, yeast A, proteinase-A, pseudo-proteinase A, Saccharomyces aspartic proteinase, Saccharomyces cerevisiae aspartic proteinase A, saccharopepsin, vacuolar aspartic proteinase, yeast aspartic proteinase A, Yeast endopeptidase A, yeast proteinase, Yeast proteinase A
ECTree
Organism
Organism on EC 3.4.23.25 - saccharopepsin
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SwissProt
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30696, 30697, 30698, 30699, 30700, 30701, 30702, 30703, 30704, 30706, 30707, 30709, 30711, 30712, 650379, 667602, 687670 -
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SwissProt
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2 molecular forms: MW 45000 (A') and 54000 (A)
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baker's yeast
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carrying the gene PEP4 which encodes the prepro-proteinase A on multicopy plasmids, 7:3 mixture of two different forms of enzyme: 40000 MW and 42000 MW
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expression in Xenopus oocytes
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PEP4 deletion mutant, PEP4 gene disruption resulted in strongly decreased available nitrogen content after alcoholic fermentation
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strains W303, W303 pep4D::HIS3, W303 pDP34, W303 pDP34-PEP4, and W303 p416ADHPEP4-GFP enzyme, increased enzyme expression induced by oxidative damage prevents the accumulation of oxidized proteins, disruption of PEP4 results in strongly decreased degradation of oxidized proteins
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wild type and PEP4, PRB1, and PRC1 deficiency mutants
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wild type and proteinase B deficiency strain, in wild-type strains, proPrA is activated to mature PrA with a molecular weight of 42000 Da, whereas in PrB-deficient strains PrA maturation is delayed and a mature pseudo-form of PrA with a molecular weight of 43000 Da is detected
SwissProt
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yeast
SwissProt
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yeast
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yeast, Lot No. 102H8510
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