3.4.23.23: Mucorpepsin

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For detailed information about Mucorpepsin, go to the full flat file.

Reaction

Hydrolysis of proteins, favouring hydrophobic residues at P1 and P1'. Clots milk. Does not accept Lys at P1, and hence does not activate trypsinogen =

Synonyms

acid proteinase, aspartic protease, Aspartic proteinase, aspartyl proteinase, EC 3.4.23.6, EC 3.4.4.17, fibrinolytic enzyme, Fromase 100, Fromase 46TL, MCAP, MMP, MPR, Mucor acid protease, Mucor acid proteinase, Mucor aspartic proteinase, Mucor miehei aspartic protease, Mucor miehei aspartic proteinase, Mucor miehei rennin, Mucor pusillus emporase, Mucor pusillus pepsin, Mucor pusillus rennin, Mucor rennin, Proteinase, Mucor aspartic, R. pusillus pepsin, rennin, RMP

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.23 Mucorpepsin

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Results	in table
6	AA Sequence
4	Application
1	CAS Registry Number
5	Cloned(Commentary)
7	Crystallization (Commentary)
1	General Stability
71	Inhibitors
7	kcat/KM [mM/s]
17	KM Value [mM]
4	Localization
13	Metals/Ions
22	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
74	Organism
4	Oxidation Stability
7	PDB ID
34	pH Optimum
4	pH Range
9	pH Stability
9	pI Value
13	Posttranslational Modification
16	Protein Variants
17	Purification (Commentary)
1	Reaction
1	Reaction Type
74	Reference
3	Source Tissue
6	Specific Activity [micromol/min/mg]
137	Substrates and Products (Substrate)
22	Subunits
75	Synonyms
19	Temperature Optimum [°C]
3	Temperature Range [°C]
15	Temperature Stability [°C]
11	Turnover Number [1/s]

pH Stability

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pH Stability on EC 3.4.23.23 - Mucorpepsin

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pH STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

3 - 5

Rhizomucor miehei

-

-

743030

3 - 6

3 entries

3 - 7

Rhizomucor pusillus

-

acid protease C, highest stability at pH 4.0

30649

3.3 - 3.8

Mucor circinelloides

U5HT00

the enzyme remains stable after 1 h at pH 3.3-3.6. The activity drops to about 60% and about 50% after 1 h at pH 3.7 and 3.8, respectively

752456

4 - 4.2

Rhizomucor miehei

-

highest thermal stability

30659

4 - 8

Rhizomucor pusillus

-

acid protease D, highest stability at pH 5.0

30649

5

Rhizomucor pusillus

-

60°C, 10 min, highest stability

30668

3 - 6

Rhizomucor miehei

-

stable

30642

3 - 6

Rhizomucor miehei

-

38°C, 8 days, more than 90% of the activity retained

30673

3 - 6

Rhizomucor pusillus

-

highest stability

30679