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3.4.23.23: Mucorpepsin

This is an abbreviated version!
For detailed information about Mucorpepsin, go to the full flat file.

Word Map on EC 3.4.23.23

Reaction

Hydrolysis of proteins, favouring hydrophobic residues at P1 and P1'. Clots milk. Does not accept Lys at P1, and hence does not activate trypsinogen =

Synonyms

acid proteinase, aspartic protease, Aspartic proteinase, aspartyl proteinase, EC 3.4.23.6, EC 3.4.4.17, fibrinolytic enzyme, Fromase 100, Fromase 46TL, MCAP, MMP, MPR, Mucor acid protease, Mucor acid proteinase, Mucor aspartic proteinase, Mucor miehei aspartic protease, Mucor miehei aspartic proteinase, Mucor miehei rennin, Mucor pusillus emporase, Mucor pusillus pepsin, Mucor pusillus rennin, Mucor rennin, Proteinase, Mucor aspartic, R. pusillus pepsin, rennin, RMP

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.23 Mucorpepsin

Inhibitors

Inhibitors on EC 3.4.23.23 - Mucorpepsin

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
complete inhibition at 1 mM
1,2-epoxy-3-(4-nitrophenoxy)propane
2,4-Dinitro-1-fluorobenzene
-
-
2-mercaptoethanol
-
97.7% residual activity at 5 mM
Aprotinin
-
72.6% residual activity at 1 mM
Co2+
-
54.09% residual activity at 10 mM
CP-113972
-
i.e. (2R,3S)-isopropyl 3-[(L-prolyl-p-iodo-L-phenylalanyl-S-methyl-cysteinyl)amino-4]-2-hydroxybutanoate, human renin inhibitor
Diazo-H-tetrazole
-
-
Diazoacetyl-DL-norleucine methyl ester
Diazoacetyl-glycyl ethyl ester
-
in presence of copper ions
dithiothreitol
-
100 mM, 50% residual activity
EDTA
-
71.1% residual activity at 50 mM
Iodine
leupeptin
-
96.5% residual activity at 0.2 mM
Mg2+
-
92.73% residual activity at 5 mM
Na+
-
91.59% residual activity at 2.5 mM
pepstatin
pepstatin A
phenylmethylsulfonyl fluoride
SDS
-
0.02%, 50% residual activity
Tetranitromethane
-
-
Triton X-100
-
0.2%, 60% residual activity
additional information
-