3.4.23.23: Mucorpepsin

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For detailed information about Mucorpepsin, go to the full flat file.

Reaction

Hydrolysis of proteins, favouring hydrophobic residues at P1 and P1'. Clots milk. Does not accept Lys at P1, and hence does not activate trypsinogen =

Synonyms

acid proteinase, aspartic protease, Aspartic proteinase, aspartyl proteinase, EC 3.4.23.6, EC 3.4.4.17, fibrinolytic enzyme, Fromase 100, Fromase 46TL, MCAP, MMP, MPR, Mucor acid protease, Mucor acid proteinase, Mucor aspartic proteinase, Mucor miehei aspartic protease, Mucor miehei aspartic proteinase, Mucor miehei rennin, Mucor pusillus emporase, Mucor pusillus pepsin, Mucor pusillus rennin, Mucor rennin, Proteinase, Mucor aspartic, R. pusillus pepsin, rennin, RMP

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.23 Mucorpepsin

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Results	in table
6	AA Sequence
4	Application
1	CAS Registry Number
5	Cloned(Commentary)
7	Crystallization (Commentary)
1	General Stability
71	Inhibitors
7	kcat/KM [mM/s]
17	KM Value [mM]
4	Localization
13	Metals/Ions
22	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
74	Organism
4	Oxidation Stability
7	PDB ID
34	pH Optimum
4	pH Range
9	pH Stability
9	pI Value
13	Posttranslational Modification
16	Protein Variants
17	Purification (Commentary)
1	Reaction
1	Reaction Type
74	Reference
3	Source Tissue
6	Specific Activity [micromol/min/mg]
137	Substrates and Products (Substrate)
22	Subunits
75	Synonyms
19	Temperature Optimum [°C]
3	Temperature Range [°C]
15	Temperature Stability [°C]
11	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.4.23.23 - Mucorpepsin

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

crystallizes in the orthorhombic space group P2(1)2(1)2(1), a : 41.86 A, b : 51.21 A, c : 174.24 A

Rhizomucor miehei

-

649270

hanging-drop method, orthorhombic space group P2(1)2(1)2(1), cell dimensions a : 41.86 A, b : 51.21 A, c : 174.24 A

Rhizomucor miehei

-

652776

small thin needle-like seed crystals of the native enzyme grown by the hanging-drop vapour-diffusion method, unit-cell dimensions a : 41.82 A, 51.21 A, c : 174.24 A, in complex with inhibitor pepstatin A, orthorhombic space group P2(1)2(1)2(1), isomorphous to native RMP crystals, unit-cell dimensions are a : 41.52 A, b : 50.82 A, c : 172.71 A

Rhizomucor miehei

-

649247

-

Rhizomucor pusillus

-

30668, 30675

mutant Y75N in complex with human renin inhibitor CP-113972

Rhizomucor pusillus

-

667045

structure and refinement at 2.0 A resolution

Rhizomucor pusillus

-

30682