3.4.23.15: renin
This is an abbreviated version!
For detailed information about renin, go to the full flat file.
Word Map on EC 3.4.23.15
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3.4.23.15
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hypertension
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aldosterone
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arterial
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urinary
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cardiovascular
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cardiac
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antihypertensive
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normotensive
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gastric
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glomerular
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natriuretic
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hemodynamic
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systolic
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diastolic
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sympathetic
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ras
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angiotensin-converting
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norepinephrine
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output
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adrenal
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blocker
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prostaglandin
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ventricular
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catecholamine
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diuretic
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creatinine
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hg
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electrolyte
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placebo
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vasopressin
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captopril
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vasodilator
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cortisol
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supine
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intrarenal
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renovascular
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conscious
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pressor
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posture
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acth
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noradrenaline
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losartan
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hypotensive
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mineralocorticoid
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vasoconstriction
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enalapril
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furosemide
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anp
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medicine
-
macula
-
pharmacology
-
aceis
-
diagnostics
- 3.4.23.15
- hypertension
- aldosterone
- arterial
- urinary
- cardiovascular
- cardiac
-
antihypertensive
-
normotensive
- gastric
- glomerular
-
natriuretic
-
hemodynamic
-
systolic
-
diastolic
-
sympathetic
- ras
-
angiotensin-converting
- norepinephrine
- output
- adrenal
-
blocker
- prostaglandin
- ventricular
- catecholamine
-
diuretic
- creatinine
- hg
-
electrolyte
-
placebo
- vasopressin
- captopril
-
vasodilator
- cortisol
-
supine
-
intrarenal
-
renovascular
-
conscious
-
pressor
-
posture
- acth
- noradrenaline
- losartan
-
hypotensive
-
mineralocorticoid
-
vasoconstriction
- enalapril
- furosemide
- anp
- medicine
-
macula
- pharmacology
-
aceis
- diagnostics
Reaction
cleavage of Leu-/- bond in angiotensinogen to generate angiotensin I =
Synonyms
angiotensin-forming enzyme, angiotensinogenase, EC 3.4.4.15, EC 3.4.99.19, prorenin, REN, SVAP, SVAP A1, SVAP B1, SVAP B2, venom aspartic protease
ECTree
3.4.23.15 reninAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.4.23.15 - renin
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4-(4'-(dimethylaminophenylazo))-benzoyl-gamma-aminobutyryl-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS + H2O
4-(4'-(dimethylaminophenylazo))-benzoyl-gamma-aminobutyryl-Ile-His-Pro-Phe-His-Leu + Val-Ile-His-Thr-EDANS
-
-
-
?
4-(4-dimethylaminophenylazo)benzoic acid-IHPFHLVIHT-5-[(e-amino-ethyl)amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoic acid-IHPFHL + VIHT-5-[(e-amino-ethyl)amino]naphthalene-1-sulfonic acid
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fluorogenic peptide
-
-
?
acetyl-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser + H2O
acetyl-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu + Leu-Val-Tyr-Ser
-
-
-
?
Arg-Glu(5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acid)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(4-(4-dimethylaminophenylazo)-benzoic acid)-Arg + H2O
?
-
commercial renin peptide substrate 1
-
-
?
Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(DABCYL)-Arg + H2O
?
-
-
-
?
benzyloxycarbonyl-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser-beta-naphthylamide + H2O
?
-
-
-
-
?
benzyloxycarbonyl-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser-beta-naphthylamide + H2O
benzyloxycarbonyl-Pro-Phe-His-Leu + Leu-Val-Tyr-Ser-beta-naphthylamide
-
-
-
?
DABCYL-c-Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS + H2O
?
-
-
-
?
H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Glu + H2O
H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu + Val-Ile-His-Thr-Glu
megsin + H2O
?
-
the protein which carries a naturally occurring His-Pro-Phe sequence, is cleaved by renin at the C-terminal side of the His-Pro-Phe-Leu-Phe sequence
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-
?
N-methylanthranyl-Ile-His-Pro-Phe-His-Leu-Val-Ile-Thr-His-Lys-2,4-dinitrophenyl-D-Arg-D-Arg-NH2 + H2O
N-methylanthranyl-Ile-His-Pro-Phe-His-Leu + Val-Ile-Thr-His-Lys-2,4-dinitrophenyl-D-Arg-D-Arg-NH2
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-
-
-
?
porcine angiotensinogen + H2O
angiotensin I + angiotensinogen propeptide
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DRVYIHPFHLLVYS
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-
?
recombinant ovine angiotensinogen from CHO cells + H2O
angiotensin I + angiotensinogen propeptide
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-
-
-
?
recombinant ovine angiotensinogen from Escherichia coli + H2O
angiotensin I + angiotensinogen propeptide
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-
-
-
?
angiotensinogen + H2O
?
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role in regulating blood pressure
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-
?
angiotensinogen + H2O
angiotensin I + ?
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highly specific for Leu10-Leu11 bond in horse or rat angiotensinogen or Leu10-Val11 bond in human angiotensinogen, minimum sequence required: His-Pro-Phe-His-Leu-Leu-Val-Tyr
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-
?
angiotensinogen + H2O
angiotensin I + angiotensinogen propeptide
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-
668286, 668473, 669705, 670872, 710784, 710825, 711367, 711389, 711396, 711406, 711431, 711686, 711766, 711767, 711778, 711793, 711797, 711802, 711814, 711895, 711896, 711901, 711919, 712135, 712254, 712634, 712874, 712931, 713093, 713170, 717078, 717093, 717688, 753638
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-
?
angiotensinogen + H2O
angiotensin I + angiotensinogen propeptide
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plasma aldosterone-to-renin ratio thresholds in plasma of healthy persons, patients with hypertension and those with additional adrenal adenomas, overview
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-
?
angiotensinogen + H2O
angiotensin I + angiotensinogen propeptide
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renin is an active component of the local synovial renin-angiotensin system in rheumatoid arthritis, renin-angiotensin system in synovial fluid, overview
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-
?
angiotensinogen + H2O
angiotensin I + angiotensinogen propeptide
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the ratio of plasma renin activity to plasma aldosterone concentration is a screening test for primary aldosteronism, overview
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-
?
angiotensinogen + H2O
angiotensin I + angiotensinogen propeptide
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the ratio of plasma renin activity to plasma aldosterone concentration is a screening test for primary hyperaldosteronism, overview
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-
?
angiotensinogen + H2O
angiotensin I + angiotensinogen propeptide
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the His-Pro-Phe motif of angiotensinogen is a crucial determinant of the substrate specificity of renin. Mutant angiotensinogens in which the Ile-His-Pro-Phe-His-Leu sequence at positions 5-10 of wild-type angiotensinogen is replaced by either His-Pro-Phe-His-Leu-Leu or Ala-Ile-His-Pro-Phe-His are cleaved by renin at the C-terminal side of residues 9 and 11, respectively, while wild-type angiotensinogen is cleaved at residue 10. A triple Ala substitution for the His-Pro-Phe motif of angiotensinogen prevents its cleavage by renin. In contrast, triple Ala substitution for residues 9-11, including the natural site of cleavage by renin, allows cleavage between the two Ala residues at positions 10 and 11
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-
?
angiotensinogen + H2O
angiotensin I + angiotensinogen propeptide
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renin catalyses the rate-limiting step in the system and has unique specificity for its substrate angiotensinogen
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-
?
angiotensinogen + H2O
angiotensin I + angiotensinogen propeptide
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renin cleaves the Leu10-Leu11 bond
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-
?
angiotensinogen + H2O
angiotensin I + angiotensinogen propeptide
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renin is a highly specific enzyme for angiotensinogen
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-
?
angiotensinogen + H2O
angiotensin I + angiotensinogen propeptide
DRVYIHPFHLVIHNESTC
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-
?
angiotensinogen + H2O
angiotensin I + angiotensinogen propeptide
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-
-
-
?
angiotensinogen + H2O
angiotensin I + angiotensinogen propeptide
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enzyme activity is increased in hypertensive mice
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-
?
angiotensinogen + H2O
angiotensin I + angiotensinogen propeptide
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the renin-angiotensin system is responsible for regulation of blood pressure and electrolytic balance
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-
?
angiotensinogen + H2O
angiotensin I + angiotensinogen propeptide
-
-
-
-
?
angiotensinogen + H2O
angiotensin I + angiotensinogen propeptide
-
-
-
-
?
angiotensinogen + H2O
angiotensin I + angiotensinogen propeptide
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high glucose concentration stimulates intracellular renin activity and angiotensin II generation in mesangial cells, mechanism, the renin-angiotensin system is involved in diabetic nephropathy, overview
-
-
?
H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Glu + H2O
H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu + Val-Ile-His-Thr-Glu
-
-
-
?
H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Glu + H2O
H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu + Val-Ile-His-Thr-Glu
-
-
-
?
additional information
?
-
-
the enzyme possesses no general protease activity
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-
?
additional information
?
-
tissue-specific renin-angiotensin system in pulmonary lymphangioleiomyomatosis in LAM cells promotes cell proliferation and migration together with LAM nodules, overview
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-
?
additional information
?
-
-
tissue-specific renin-angiotensin system in pulmonary lymphangioleiomyomatosis in LAM cells promotes cell proliferation and migration together with LAM nodules, overview
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-
?
additional information
?
-
-
the main role of the enzyme is the intracellular generation of angiotensin
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?
additional information
?
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the main role of the enzyme is the intracellular generation of angiotensin
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?
additional information
?
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possible binding mechanism of prorenin and renin to the renin/prorenin receptor, overview
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-
?
