3.4.23.15: renin

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For detailed information about renin, go to the full flat file.

Word Map on EC 3.4.23.15

3.4.23.15

hypertension

aldosterone

arterial

urinary

cardiovascular

cardiac

antihypertensive

normotensive

gastric

glomerular

natriuretic

hemodynamic

systolic

diastolic

sympathetic

ras

angiotensin-converting

norepinephrine

output

adrenal

blocker

prostaglandin

ventricular

catecholamine

diuretic

creatinine

hg

electrolyte

placebo

vasopressin

captopril

vasodilator

cortisol

supine

intrarenal

renovascular

conscious

pressor

posture

acth

noradrenaline

losartan

hypotensive

mineralocorticoid

vasoconstriction

enalapril

furosemide

anp

medicine

macula

pharmacology

aceis

diagnostics

Reaction

cleavage of Leu-/- bond in angiotensinogen to generate angiotensin I =

Synonyms

angiotensin-forming enzyme, angiotensinogenase, EC 3.4.4.15, EC 3.4.99.19, prorenin, REN, SVAP, SVAP A1, SVAP B1, SVAP B2, venom aspartic protease

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.23 Aspartic endopeptidases

3.4.23.15 renin

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Results	in table
1	Activating Compound
205	AA Sequence
26	Application
1	CAS Registry Number
23	Cloned(Commentary)
9	Crystallization (Commentary)
38807	Disease/ Diagnostics
17	Expression
6	General Information
8	General Stability
283	IC50 Value
452	Inhibitors
3	kcat/KM [mM/s]
38	Ki Value [mM]
21	KM Value [mM]
15	Localization
41	Molecular Weight [Da]
65	Natural Substrates/ Products (Substrates)
171	Organism
191	PDB ID
17	pH Optimum
3	pH Range
1	pH Stability
23	Posttranslational Modification
6	Protein Variants
30	Purification (Commentary)
2	Reaction
1	Reaction Type
171	Reference
123	Source Tissue
40	Specific Activity [micromol/min/mg]
12	Storage Stability
111	Substrates and Products (Substrate)
12	Subunits
15	Synonyms
3	Temperature Optimum [°C]
8	Turnover Number [1/s]

Purification

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Purification on EC 3.4.23.15 - renin

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2 components

2 forms

2 isoenzymes

3 forms

3 isoenzymes

5 forms

ammonium sulfate precipitation and Resource S column chromatography

Homo sapiens

753084

full-length prorenin is expressed in HEK 293 cells, purified and converted to its active form by trypsin-mediated cleavage of the 43 residue propeptide

Canis lupus familiaris

Q6DYE7

680561

inactive renin, activated by trypsin

Homo sapiens

95755

Mono Q column chromatography and phenyl Superose column chromatography

Echis ocellatus

755599

post-transitionally modified forms

prorenin

prorenin activated by trypsin

Rattus norvegicus

95808

recombinant renin

2 entries

renin and gamma-renin

Mus musculus

29366

Superdex S200 gel filtration

Homo sapiens

P00797

754182