3.4.23.12: nepenthesin

This is an abbreviated version!
For detailed information about nepenthesin, go to the full flat file.

Reaction

Similar to pepsin, but also cleaves on either side of Asp and at Lys-/-Arg =

Synonyms

EC 3.4.99.4, More, Nep I, Nep II, Nep1, nepenthacin, nepenthasin;aspartyl endopeptidase, nepenthes aspartic protease, Nepenthesin, nepenthesin I, nepenthesin II, nepenthesin IIa, nepenthesin IIb, NepI, NEPII, proteinase, nepenthes acid

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.12 nepenthesin

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Results	in table
238	AA Sequence
1	CAS Registry Number
7	Cloned(Commentary)
1	Crystallization (Commentary)
5	Expression
1	General Information
36	Inhibitors
1	Localization
7	Molecular Weight [Da]
16	Natural Substrates/ Products (Substrates)
5	Organic Solvent Stability
28	Organism
6	pH Optimum
4	pH Range
6	pH Stability
2	pI Value
2	Posttranslational Modification
8	Purification (Commentary)
3	Reaction
1	Reaction Type
27	Reference
19	Source Tissue
1	Specific Activity [micromol/min/mg]
49	Substrates and Products (Substrate)
10	Subunits
29	Synonyms
9	Temperature Optimum [°C]
3	Temperature Range [°C]
5	Temperature Stability [°C]

Natural Substrates Products

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Natural Substrates Products on EC 3.4.23.12 - nepenthesin

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

Hemoglobin + H2O

?

Nepenthes gracilis

-

-

753939

-

-

?

Peptides + H2O

?

10 entries

Peptides + H2O

?

Cynara cardunculus

-

preferential cleavage: -Asp, Asp-, Lys-, Ala-

36778

-

-

?

Peptides + H2O

?

Drosera capensis

-

preferential cleavage: -Asp, Asp-, Lys-, Ala-

36777

-

-

?

Peptides + H2O

?

Drosera peltata

-

preferential cleavage: -Asp, Asp-, Lys-, Ala-

36773, 36774

-

-

?

Peptides + H2O

?

Nepenthes alata

-

preferential cleavage: -Asp, Asp-, Lys-, Ala-

36776

-

-

?

Peptides + H2O

?

Nepenthes ampullaria

-

preferential cleavage: -Asp, Asp-, Lys-, Ala-

36777

-

-

?

Peptides + H2O

?

Nepenthes dormaniana

-

preferential cleavage: -Asp, Asp-, Lys-, Ala-

36772

-

-

?

Peptides + H2O

?

Nepenthes mixta

-

preferential cleavage: -Asp, Asp-, Lys-, Ala-

36772

-

-

?

Peptides + H2O

?

Nepenthes neufvilleana

-

preferential cleavage: -Asp, Asp-, Lys-, Ala-

36772

-

-

?

Peptides + H2O

?

Nepenthes sp.

-

preferential cleavage: -Asp, Asp-, Lys-, Ala-

36771, 36772, 36773, 36774, 36775

-

-

?

Peptides + H2O

?

Sus scrofa

-

preferential cleavage: -Asp, Asp-, Lys-, Ala-

36777

-

-

?