3.4.23.12: nepenthesin
This is an abbreviated version!
For detailed information about nepenthesin, go to the full flat file.
Word Map on EC 3.4.23.12
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3.4.23.12
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pitcher
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carnivorous
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pepsin
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prey
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gracilis
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low-ph
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hdx-ms
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forbidden
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asteraceae
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acid-denatured
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carnivory
- 3.4.23.12
-
pitcher
-
carnivorous
- pepsin
-
prey
- gracilis
-
low-ph
-
hdx-ms
-
forbidden
- asteraceae
-
acid-denatured
-
carnivory
Reaction
Similar to pepsin, but also cleaves on either side of Asp and at Lys-/-Arg =
Synonyms
EC 3.4.99.4, More, Nep I, Nep II, Nep1, nepenthacin, nepenthasin;aspartyl endopeptidase, nepenthes aspartic protease, Nepenthesin, nepenthesin I, nepenthesin II, nepenthesin IIa, nepenthesin IIb, NepI, NEPII, proteinase, nepenthes acid
ECTree
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Inhibitors
Inhibitors on EC 3.4.23.12 - nepenthesin
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4-(2-aminoethyl)benzenesulfonyl fluoride
about 70% residual activity at 0.1 mM
cupric ions
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strong inhibition of nepenthesin I and II by diazoacetyl-DL-norleucine in presence of cupric ions, no inactivation in absence of cupric ions
diazoacetyl-DL-norleucine
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strong inhibition of nepenthesin I and II in presence of cupric ions, no inactivation in absence of cupric ions
dithiothreitol
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isoforms nethepsin I, IIa and IIb are completely inactivated in the presence of 40-70 mM dithiothreitol
guanidine hydrochloride
isoform NepII shows about 85% residual activity at 4 M, about 50% residual activity at 5 M, and is completely inhibited at 6 M guanidine hydrochloride; isoform NepI shows about 50% residual activity at 1 M and is completely inhibited at 4 M guanidine hydrochloride
Urea
isoform NepI shows about 85% residual activity at 4 M and is completely inhibited at 6 M urea