3.4.23.1: pepsin A

This is an abbreviated version!
For detailed information about pepsin A, go to the full flat file.

Word Map on EC 3.4.23.1

3.4.23.1

gastric

mucosa

porcine

ulcer

pylori

helicobacter

stomach

gastritis

proteinases

peptic

juice

chymosin

atrophic

zymogen

pepstatin

reflux

isozymogens

gastricsin

endoscopy

omeprazole

progastricsins

prosegment

fundic

pentagastrin

prochymosins

milk-clotting

medicine

synthesis

abomasum

hypergastrinaemia

nutrition

pylori-positive

analysis

food industry

Reaction

Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-/-Val, Gln4-/-His, Glu13-/-Ala, Ala14-/-Leu, Leu15-/-Tyr, Tyr16-/-Leu, Gly23-/-Phe, Phe24-/-Phe and Phe25-/-Tyr bonds in the B chain of insulin =

Synonyms

Aspartic proteinase, EC 3.4.4.1, elixir lactate of pepsin, fundus-pepsin, lactated pepsin, lactated pepsin elixir, P I, P-Ia, P-Ib, P-II, P-III, pep/PAG-L, pepsin, pepsin 1, pepsin A, pepsin A1, pepsin A2, pepsin D, pepsin fortior, Pepsin I/II, pepsin R, pepsinogen A, pepsinogen/PAG-Like, pepsins A1, pepsins A2, PG1, PG1-1, PG2, PG2-2, shewasin A, shewasin D

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.23 Aspartic endopeptidases

3.4.23.1 pepsin A

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Results	in table
3	Activating Compound
154	AA Sequence
10	Application
1	CAS Registry Number
11	Cloned(Commentary)
11	Crystallization (Commentary)
2972	Disease/ Diagnostics
1	General Information
3	General Stability
10	IC50 Value
151	Inhibitors
46	kcat/KM [mM/s]
5	Ki Value [mM]
145	KM Value [mM]
1	Localization
3	Metals/Ions
30	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
6	Organic Solvent Stability
124	Organism
23	PDB ID
51	pH Optimum
25	pH Range
24	pH Stability
11	pI Value
8	Posttranslational Modification
34	Protein Variants
40	Purification (Commentary)
1	Reaction
1	Reaction Type
121	Reference
4	Renatured (Commentary)
49	Source Tissue
10	Specific Activity [micromol/min/mg]
4	Storage Stability
235	Substrates and Products (Substrate)
25	Subunits
58	Synonyms
25	Temperature Optimum [°C]
7	Temperature Range [°C]
10	Temperature Stability [°C]
136	Turnover Number [1/s]

pH Optimum

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pH Optimum on EC 3.4.23.1 - pepsin A

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1.5

Micropterus salmoides

isoform PG1-1, for hemoglobin digestion

1.5 - 2

1.8

N,N-dimethylcasein, N,N-dimethylhemoglobin

36758

1.85

Ovis aries

N-acetyl-L-phenylalanyl-L-diiodotyrosine

2 - 3

2.1

2.2

2.5

2.8

3.5

3.5 - 4

Shewanella denitrificans

Q12R32

755425

3.8 - 4.5

Shewanella amazonensis

4.6

benzyloxycarbonyl-L-histidyl-L-phenylalanyl-L-tryptophan ethyl ester

36758

additional information

9 entries