3.4.23.1: pepsin A

This is an abbreviated version!
For detailed information about pepsin A, go to the full flat file.

Reaction

Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-/-Val, Gln4-/-His, Glu13-/-Ala, Ala14-/-Leu, Leu15-/-Tyr, Tyr16-/-Leu, Gly23-/-Phe, Phe24-/-Phe and Phe25-/-Tyr bonds in the B chain of insulin =

Synonyms

Aspartic proteinase, EC 3.4.4.1, elixir lactate of pepsin, fundus-pepsin, lactated pepsin, lactated pepsin elixir, P I, P-Ia, P-Ib, P-II, P-III, pep/PAG-L, pepsin, pepsin 1, pepsin A, pepsin A1, pepsin A2, pepsin D, pepsin fortior, Pepsin I/II, pepsin R, pepsinogen A, pepsinogen/PAG-Like, pepsins A1, pepsins A2, PG1, PG1-1, PG2, PG2-2, shewasin A, shewasin D

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.1 pepsin A

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Results	in table
3	Activating Compound
154	AA Sequence
10	Application
1	CAS Registry Number
11	Cloned(Commentary)
11	Crystallization (Commentary)
2972	Disease/ Diagnostics
1	General Information
3	General Stability
10	IC50 Value
151	Inhibitors
46	kcat/KM [mM/s]
5	Ki Value [mM]
145	KM Value [mM]
1	Localization
3	Metals/Ions
30	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
6	Organic Solvent Stability
124	Organism
23	PDB ID
51	pH Optimum
25	pH Range
24	pH Stability
11	pI Value
8	Posttranslational Modification
34	Protein Variants
40	Purification (Commentary)
1	Reaction
1	Reaction Type
121	Reference
4	Renatured (Commentary)
49	Source Tissue
10	Specific Activity [micromol/min/mg]
4	Storage Stability
235	Substrates and Products (Substrate)
25	Subunits
58	Synonyms
25	Temperature Optimum [°C]
7	Temperature Range [°C]
10	Temperature Stability [°C]
136	Turnover Number [1/s]

Temperature Optimum

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Temperature Optimum on EC 3.4.23.1 - pepsin A

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TEMPERATURE OPTIMUM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

30

Oncorhynchus mykiss

-

isoforms P-II and P-III

753464

30 - 37

Shewanella denitrificans

Q12R32

-

755425

35

Lateolabrax japonicus

E2IKQ9

-

717514

37

10 entries

40

3 entries

42

2 entries

42 - 50

Shewanella amazonensis

A1S3N8

maximum activity is observed at temperatures between 42 and 50°C, decreasing so drastically above 50°C that complete loss of activity is detected at 60°C

717595

45

Albatrossia pectoralis

-

-

679335

50

2 entries

50 - 65

Gallus gallus

-

-

36768

57

Sus scrofa

-

-

753846

37

dogfish

-

assay at

35005

37

Gallus gallus

-

assay at

35005

37

Homo sapiens

-

assay at

35010

37

Macaca fuscata fuscata

-

assay at

36746

37

Parona signata

-

-

36766

37

salmon

-

assay at

35005

37

Scombridae gen. sp.

-

assay at

35005

37

shark

-

assay at

35005

37

Sus scrofa

-

assay at

35005, 35010

37

Trematomus bernacchii

Q6HA04, Q6HA05

-

679796

40

Micropterus salmoides

-

isoform PG2-2

753325

40

Monopterus albus

-

the activity of pepsin isoform 1 is largely lost at higher than 50°C

717613

40

Oncorhynchus mykiss

-

isoform P-I

753464

42

Homo sapiens

-

assay at

35010

42

Sus scrofa

-

assay at

35010

50

Micropterus salmoides

-

isoform PG1-1

753325

50

Trematomus bernacchii

Q6HA04, Q6HA05

-

679796