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3.4.23.1: pepsin A

This is an abbreviated version!
For detailed information about pepsin A, go to the full flat file.

Word Map on EC 3.4.23.1

Reaction

Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-/-Val, Gln4-/-His, Glu13-/-Ala, Ala14-/-Leu, Leu15-/-Tyr, Tyr16-/-Leu, Gly23-/-Phe, Phe24-/-Phe and Phe25-/-Tyr bonds in the B chain of insulin =

Synonyms

Aspartic proteinase, EC 3.4.4.1, elixir lactate of pepsin, fundus-pepsin, lactated pepsin, lactated pepsin elixir, P I, P-Ia, P-Ib, P-II, P-III, pep/PAG-L, pepsin, pepsin 1, pepsin A, pepsin A1, pepsin A2, pepsin D, pepsin fortior, Pepsin I/II, pepsin R, pepsinogen A, pepsinogen/PAG-Like, pepsins A1, pepsins A2, PG1, PG1-1, PG2, PG2-2, shewasin A, shewasin D

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.1 pepsin A

Organic Solvent Stability

Organic Solvent Stability on EC 3.4.23.1 - pepsin A

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ORGANIC SOLVENT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1,4-dioxane
-
incubation for 20 min at pH 2 and 25°C, the enzyme retains its activity in aqueous 1,4-dioxane with increasing organic solvent concentration up to 30%
acetonitrile
-
incubation for 20 min at pH 2 and 25°C, the enzyme retains its activity in aqueous acetonitrile with increasing organic solvent concentration up to 60%
Ethanol
-
incubation for 20 min at pH 2 and 25°C, the enzyme retains its activity in aqueous ethanol with increasing organic solvent concentration up to 60%
guanidine-HCl
-
pepsin A is stable up to 3.6 M and inactivated at 5 M guanidine-HCl
Methanol
-
aqueous methanol cryosolvents: no deleterious effect
urea
-
pepsin A is stable up to at least 5.6 M urea