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3.4.23.1: pepsin A

This is an abbreviated version!
For detailed information about pepsin A, go to the full flat file.

Word Map on EC 3.4.23.1

Reaction

Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-/-Val, Gln4-/-His, Glu13-/-Ala, Ala14-/-Leu, Leu15-/-Tyr, Tyr16-/-Leu, Gly23-/-Phe, Phe24-/-Phe and Phe25-/-Tyr bonds in the B chain of insulin =

Synonyms

Aspartic proteinase, EC 3.4.4.1, elixir lactate of pepsin, fundus-pepsin, lactated pepsin, lactated pepsin elixir, P I, P-Ia, P-Ib, P-II, P-III, pep/PAG-L, pepsin, pepsin 1, pepsin A, pepsin A1, pepsin A2, pepsin D, pepsin fortior, Pepsin I/II, pepsin R, pepsinogen A, pepsinogen/PAG-Like, pepsins A1, pepsins A2, PG1, PG1-1, PG2, PG2-2, shewasin A, shewasin D

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.1 pepsin A

Inhibitors

Inhibitors on EC 3.4.23.1 - pepsin A

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,2-epoxy-3-(4-nitrophenoxy)propane
acotiamide
-
the activity of pepsin decreases with the increasing concentration of acotiamide (0-0.02 mM)
alpha2-Macroglobulin
-
activity towards reduced and carboxymethylated ribonuclease A is significantly inhibited at pH 5.5, the activity towards a peptide substrate, oxidized insulin B-chain, is scarcely inhibited
-
amastatin
97.2 residual activity at 0.01 mM
amylopectin sulfate
-
apigenin
-
baicalein
-
bestatin
92.7 residual activity at 0.01 mM
Bis-(beta-chloroethyl)sulfide
daidzein
-
Diazoacetyl-DL-norleucine methyl ester
dimethyl sulfoxide
-
1%, complete loss of activity
dithiothreitol
E-64
89.5 residual activity at 0.01 mM
genistein
-
imidazole
iodoacetamide
82.1 residual activity at 0.05 mM
kaempferol
-
leupeptin
91.9 residual activity at 0.01 mM
liquiritigenin
-
luteolin
-
N-bromosuccinimide
NaCl
-
30%, activity of pepsin A decreases by 60-65%
naringenin
-
p-bromophenylacyl bromide
pefabloc
87.8 residual activity at 1 mM
pepstatin
pepstatin A
peptides
PI-3
-
inhibitor from Ascaris suum
-
poly-L-lysine
prosegment K36A-mutant of pepsinogen
-
N-terminal, 44 residue prosegment
-
prosegment of pepsinogen
-
N-terminal, 44 residue prosegment
-
prosegment R8A-mutant of pepsinogen
-
N-terminal, 44 residue prosegment
-
prosegment V4A-mutant of pepsinogen
-
N-terminal, 44 residue prosegment
-
quercetin
-
Tetranitromethane
Val-D-Leu-Pro-Phe-Phe-Val-D-Leu
additional information
-