3.4.22.B8: Tpr proteinase (Porphyromonas gingivalis)
This is an abbreviated version!
For detailed information about Tpr proteinase (Porphyromonas gingivalis), go to the full flat file.
Word Map on EC 3.4.22.B8
Reaction
Synonyms
C02.022, Tpr peptidase
ECTree
3.4.22.B8 Tpr proteinase (Porphyromonas gingivalis)Advanced search results
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results (Substrates Products
Substrates Products on EC 3.4.22.B8 - Tpr proteinase (Porphyromonas gingivalis)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
denatured collagen + H2O
?
no activity on native collagen
-
-
?
Suc-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O
?
-
-
-
?
Z-Phe-Arg-7-amido-4-methylcoumarin + H2O
?
-
-
-
?
additional information
?
-
no activity on synthetic peptides such as BAPNA and Gly-Pro-nitroanilide
-
-
?
additional information
?
-
the protease constitutes an important virulence factor
-
-
?
additional information
?
-
-
inducible expression, regulation occurs at the transcriptional level
-
-
?
additional information
?
-
-
expression is suppressed by the addition of peptide and protein nutrients to a peptide-limited growth medium but is only slightly affected by addition of free amino acids. Phe-containing peptides are a major factor controlling Trp expression
-
-
?
additional information
?
-
no or poor substrates: Arg-pNA, Z-Tyr-Val-Ala-Asp-AFC, Ac-Asp-Glu-Val-Asp-AFC, Ac-Leu-Glu-His-Asp-AFC, Z-Ala-Ala-Asn-AMC, H-Gly-Phe-AMC, Boc-Val-Leu-Lys-AMC, Suc-Leu-Leu-Val-Tyr-pNA, Z-Phe-Arg-pNA, Boc-Ala-Ala-Gly-pNA, H-Leu-Gly-pNA, Suc-Ala-Ala-Ala-pNa, Suc-Ala-Ala-Pro-PhepNA, N-carbobenzyloxy-Arg-pNA, Z-Arg-Arg-AMC, DQ-gelatin, azocoll, and azocasein
-
-
?
additional information
?
-
no or poor substrates: Arg-pNA, Z-Tyr-Val-Ala-Asp-AFC, Ac-Asp-Glu-Val-Asp-AFC, Ac-Leu-Glu-His-Asp-AFC, Z-Ala-Ala-Asn-AMC, H-Gly-Phe-AMC, Boc-Val-Leu-Lys-AMC, Suc-Leu-Leu-Val-Tyr-pNA, Z-Phe-Arg-pNA, Boc-Ala-Ala-Gly-pNA, H-Leu-Gly-pNA, Suc-Ala-Ala-Ala-pNa, Suc-Ala-Ala-Pro-PhepNA, N-carbobenzyloxy-Arg-pNA, Z-Arg-Arg-AMC, DQ-gelatin, azocoll, and azocasein
-
-
?
additional information
?
-
no activity on synthetic peptides such as BAPNA and Gly-Pro-nitroanilide
-
-
?
additional information
?
-
the protease constitutes an important virulence factor
-
-
?
