3.4.22.B73: SENP5 peptidase
This is an abbreviated version!
For detailed information about SENP5 peptidase, go to the full flat file.
Word Map on EC 3.4.22.B73
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3.4.22.B73
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senps
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desumoylation
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deconjugation
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isopeptidase
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mitosis
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fission
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nucleolus
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regulator-related
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medicine
- 3.4.22.B73
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senps
-
desumoylation
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deconjugation
- isopeptidase
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mitosis
-
fission
- nucleolus
-
regulator-related
- medicine
Reaction
SENP5 additional information efficiently removes SUMO-2 and SUMO-3 than SUMO-1 from SUMO-modified target such as Ran GTPase-activating protein 1. Catalyzes desumoylation of mitochondrial fission GTPase DRP1. =
Synonyms
SENP5, SENP5 peptidase, sentrin/small ubiquitin-like modifier-specific protease5, SUMO isopeptidase, SUMO-specific protease 5
ECTree
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Substrates Products
Substrates Products on EC 3.4.22.B73 - SENP5 peptidase
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REACTION DIAGRAM
(SUMO-1)-mitochondrial fission GTPase DRP1 congugate + H2O
SUMO-1 + mitochondrial fission GTPase DRP1
(SUMO-1)-Ran GTPase-activating protein 1 conjugate + H2O
SUMO-1 + Ran GTPase-activating protein 1
SENP5 more efficiently removes SUMO-2 and SUMO-3 than SUMO-1 from SUMO-modified Ran GTPase-activating protein 1 conjugate
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-
?
(SUMO-2)-Ran GTPase-activating protein 1 conjugate + H2O
SUMO-2 + Ran GTPase-activating protein 1
SENP5 more efficiently removes SUMO-2 and SUMO-3 than SUMO-1 from SUMO-modified Ran GTPase-activating protein 1 conjugate
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-
?
(SUMO-3)-Ran GTPase-activating protein 1 conjugate + H2O
SUMO-3 + Ran GTPase-activating protein 1
SENP5 more efficiently removes SUMO-2 and SUMO-3 than SUMO-1 from SUMO-modified Ran GTPase-activating protein 1 conjugate
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-
?
SUMO-1 precursor + H2O
SUMO-1 + His-Ser-Thr-Val
the catalytic domain of SENP5 shows higher efficiency for processing SUMO-3 over SUMO-1 precursors in vitro
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-
?
SUMO-3 precursor + H2O
SUMO-3 + Val-Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe
the catalytic domain of SENP5 shows higher efficiency for processing SUMO-3 over SUMO-1 precursors in vitro
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-
?
SUMOylated ATRIP + H2O
?
ATRIP i.e regulator of ATR, ATM [ataxia telangiectasia-mutated]- and Rad3-related kinase
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-
?
SUMOylated dynamin related protein + H2O
dynamin related protein + SUMO
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-
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?
SUMO-1 + mitochondrial fission GTPase DRP1
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-
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-
?
(SUMO-1)-mitochondrial fission GTPase DRP1 congugate + H2O
SUMO-1 + mitochondrial fission GTPase DRP1
SENP5 catalyzes the cleavage of SUMO1 from a number of mitochondrial substrates. SENP5 is a new regulator of SUMO1 proteolysis from mitochondrial targets, impacting mitochondrial morphology and metabolism
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-
?
(SUMO-1)-mitochondrial fission GTPase DRP1 congugate + H2O
SUMO-1 + mitochondrial fission GTPase DRP1
SENP5 preferentially deSUMOylates SUMO2 and SUMO3 proteins
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-
?