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3.4.22.B73: SENP5 peptidase

This is an abbreviated version!
For detailed information about SENP5 peptidase, go to the full flat file.

Word Map on EC 3.4.22.B73

Reaction

SENP5 additional information efficiently removes SUMO-2 and SUMO-3 than SUMO-1 from SUMO-modified target such as Ran GTPase-activating protein 1. Catalyzes desumoylation of mitochondrial fission GTPase DRP1. =

Synonyms

SENP5, SENP5 peptidase, sentrin/small ubiquitin-like modifier-specific protease5, SUMO isopeptidase, SUMO-specific protease 5

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B73 SENP5 peptidase

Substrates Products

Substrates Products on EC 3.4.22.B73 - SENP5 peptidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(SUMO-1)-mitochondrial fission GTPase DRP1 congugate + H2O
SUMO-1 + mitochondrial fission GTPase DRP1
show the reaction diagram
(SUMO-1)-Ran GTPase-activating protein 1 conjugate + H2O
SUMO-1 + Ran GTPase-activating protein 1
show the reaction diagram
SENP5 more efficiently removes SUMO-2 and SUMO-3 than SUMO-1 from SUMO-modified Ran GTPase-activating protein 1 conjugate
-
-
?
(SUMO-2)-Ran GTPase-activating protein 1 conjugate + H2O
SUMO-2 + Ran GTPase-activating protein 1
show the reaction diagram
SENP5 more efficiently removes SUMO-2 and SUMO-3 than SUMO-1 from SUMO-modified Ran GTPase-activating protein 1 conjugate
-
-
?
(SUMO-3)-Ran GTPase-activating protein 1 conjugate + H2O
SUMO-3 + Ran GTPase-activating protein 1
show the reaction diagram
SENP5 more efficiently removes SUMO-2 and SUMO-3 than SUMO-1 from SUMO-modified Ran GTPase-activating protein 1 conjugate
-
-
?
SUMO-1 precursor + H2O
SUMO-1 + His-Ser-Thr-Val
show the reaction diagram
the catalytic domain of SENP5 shows higher efficiency for processing SUMO-3 over SUMO-1 precursors in vitro
-
-
?
SUMO-3 precursor + H2O
SUMO-3 + Val-Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe
show the reaction diagram
the catalytic domain of SENP5 shows higher efficiency for processing SUMO-3 over SUMO-1 precursors in vitro
-
-
?
SUMOylated ATRIP + H2O
?
show the reaction diagram
ATRIP i.e regulator of ATR, ATM [ataxia telangiectasia-mutated]- and Rad3-related kinase
-
-
?
SUMOylated dynamin related protein + H2O
dynamin related protein + SUMO
show the reaction diagram
-
-
-
-
?