3.4.22.B73: SENP5 peptidase

This is an abbreviated version!
For detailed information about SENP5 peptidase, go to the full flat file.

Word Map on EC 3.4.22.B73

3.4.22.B73

senps

desumoylation

deconjugation

isopeptidase

mitosis

fission

nucleolus

regulator-related

medicine

Reaction

SENP5 additional information efficiently removes SUMO-2 and SUMO-3 than SUMO-1 from SUMO-modified target such as Ran GTPase-activating protein 1. Catalyzes desumoylation of mitochondrial fission GTPase DRP1. =

Synonyms

SENP5, SENP5 peptidase, sentrin/small ubiquitin-like modifier-specific protease5, SUMO isopeptidase, SUMO-specific protease 5

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.22 Cysteine endopeptidases

3.4.22.B73 SENP5 peptidase

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Results	in table
1	Activating Compound
2	AA Sequence
2	Application
2	Cloned(Commentary)
75	Disease/ Diagnostics
12	General Information
13	Localization
3	Natural Substrates/ Products (Substrates)
10	Organism
1	Protein Variants
1	Purification (Commentary)
1	Reaction
10	Reference
8	Source Tissue
10	Substrates and Products (Substrate)
8	Synonyms

Reference

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Reference on EC 3.4.22.B73 - SENP5 peptidase

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681011

Zunino, R.; Schauss, A.; Rippstein, P.; Andrade-Navarro, M.; McBride, H.M.

The SUMO protease SENP5 is required to maintain mitochondrial morphology and function

J. Cell Sci.

120

1178-1188

2007

Homo sapiens (Q96HI0)

17341580

681908

Di Bacco, A.; Ouyang, J.; Lee, H.Y.; Catic, A.; Ploegh, H.; Gill, G.

The SUMO-specific protease SENP5 is required for cell division

Mol. Cell. Biol.

4489-4498

2006

Homo sapiens (Q96HI0)

16738315

715497

Zunino, R.; Braschi, E.; Xu, L.; McBride, H.M.

Translocation of SenP5 from the nucleoli to the mitochondria modulates DRP1-dependent fission during mitosis

J. Biol. Chem.

284

17783-17795

2009

Homo sapiens

19411255

715705

Yun, C.; Wang, Y.; Mukhopadhyay, D.; Backlund, P.; Kolli, N.; Yergey, A.; Wilkinson, K.D.; Dasso, M.

Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases

J. Cell Biol.

183

589-595

2008

Homo sapiens

19015314

716404

Ding, X.; Sun, J.; Wang, L.; Li, G.; Shen, Y.; Zhou, X.; Chen, W.

Overexpression of SENP5 in oral squamous cell carcinoma and its association with differentiation

Oncol. Rep.

1041-1045

2008

Homo sapiens

18949399

732349

Kim, E.Y.; Zhang, Y.; Beketaev, I.; Segura, A.M.; Yu, W.; Xi, Y.; Chang, J.; Wang, J.

SENP5, a SUMO isopeptidase, induces apoptosis and cardiomyopathy

J. Mol. Cell. Cardiol.

154-164

2015

Homo sapiens

25128087

732524

Cheng, Y.; Guo, X.; Gong, Y.; Ding, X.; Yu, Y.

Sentrin/small ubiquitin-like modifier-specific protease5 protects oral cancer cells from oxidative stress-induced apoptosis

Mol. Med. Rep.

2009-2014

2015

Homo sapiens

25901414

753503

Jin, Z.L.; Pei, H.; Xu, Y.H.; Yu, J.; Deng, T.

The SUMO-specific protease SENP5 controls DNA damage response and promotes tumorigenesis in hepatocellular carcinoma

Eur. Rev. Med. Pharmacol. Sci.

3566-3573

2016

Homo sapiens (Q96HI0)

27649656

754262

Akiyama, H.; Nakadate, K.; Sakakibara, S.I.

Synaptic localization of the SUMOylation-regulating protease SENP5 in the adult mouse brain

J. Comp. Neurol.

526

990-1005

2018

Mus musculus (Q6NXL6), Mus musculus

29277914

754569

Federzoni, E.A.; Gloor, S.; Jin, J.; Shan-Krauer, D.; Fey, M.F.; Torbett, B.E.; Tschan, M.P.

Linking the SUMO protease SENP5 to neutrophil differentiation of AML cells

Leuk. Res. Rep.

32-35

2015

Homo sapiens (Q96HI0)

25984443