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3.4.22.B67: Ulp2 peptidase

This is an abbreviated version!
For detailed information about Ulp2 peptidase, go to the full flat file.

Word Map on EC 3.4.22.B67

Reaction

Ulp2 hydrolyses the SUMO-SUMO linkage in poly-SUMO chains. It catalyzes desumoylation of SUMO-modified-Ndc10 kinetochore protein, SUMO-modified-Bir1 kinetochore protein or SUMO-modified-Cep3 kinetochore protein. =

Synonyms

At1g09730, at4g33620, probable ubiquitin-like-specific protease 2A, probable ubiquitin-like-specific protease 2B, Smt3-specific protease, SMT4, Spf1, SPF2, SUMO de-conjugating/chain-editing enzyme Ulp2p, SUMO isopeptidase Ulp2, SUMO protease, SUMO(Smt3)-specific protease, SUMO-specific protease, Ulp2, ULP2 SUMO isopeptidase, Ulp2 SUMO protease, Ulp2A, Ulp2B, Ulp2p

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B67 Ulp2 peptidase

Reference

topprint

Reference on EC 3.4.22.B67 - Ulp2 peptidase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schwartz, D.C.; Felberbaum, R.; Hochstrasser, M.
The Ulp2 SUMO protease is required for cell division following termination of the DNA damage checkpoint
Mol. Cell. Biol.
27
6948-6961
2007
Saccharomyces cerevisiae (P40537), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Kim, J.H.; Baek, S.H.
Emerging roles of desumoylating enzymes
Biochim. Biophys. Acta
1792
155-162
2009
Saccharomyces cerevisiae (P40537)
Manually annotated by BRENDA team
Felberbaum, R.; Hochstrasser, M.
Ulp2 and the DNA damage response: desumoylation enables safe passage through mitosis
Cell Cycle
7
52-56
2007
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Mullen, J.R.; Das, M.; Brill, S.J.
Genetic evidence that polysumoylation bypasses the need for a SUMO-targeted Ub ligase
Genetics
187
73-87
2011
Saccharomyces cerevisiae (P40537), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Bylebyl, G.R.; Belichenko, I.; Johnson, E.S.
The SUMO isopeptidase Ulp2 prevents accumulation of SUMO chains in yeast
J. Biol. Chem.
278
44113-44120
2003
Saccharomyces cerevisiae (P40537), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Kroetz, M.B.; Su, D.; Hochstrasser, M.
Essential role of nuclear localization for yeast Ulp2 SUMO protease function
Mol. Biol. Cell
20
2196-2206
2009
Saccharomyces cerevisiae (P40537), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Li, S.J.; Hochstrasser, M.
The yeast ULP2 (SMT4) gene encodes a novel protease specific for the ubiquitin-like Smt3 protein
Mol. Cell. Biol.
20
2367-2377
2000
Saccharomyces cerevisiae (P40537), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Schwienhorst, I.; Johnson, E.S.; Dohmen, R.J.
SUMO conjugation and deconjugation
Mol. Gen. Genet.
263
771-786
2000
Saccharomyces cerevisiae (P40537), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Lee, M.T.; Bakir, A.A.; Nguyen, K.N.; Bachant, J.
The SUMO isopeptidase Ulp2p is required to prevent recombination-induced chromosome segregation lethality following DNA replication stress
PLoS Genet.
7
e1001355
2011
Saccharomyces cerevisiae (P40537), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Eckhoff, J.; Dohmen, R.J.
In vitro studies reveal a sequential mode of chain processing by the yeast SUMO-specific protease Ulp2
J. Biol. Chem.
19
12268-12281
2015
Saccharomyces cerevisiae (P40537)
Manually annotated by BRENDA team
Lewicki, M.C.; Srikumar, T.; Johnson, E.; Raught, B.
The S. cerevisiae SUMO stress response is a conjugation-deconjugation cycle that targets the transcription machinery
J. Proteomics
118
39-48
2015
Saccharomyces cerevisiae (P40537), Saccharomyces cerevisiae BY4741/2 (P40537)
Manually annotated by BRENDA team
Jongjitwimol, J.; Feng, M.; Zhou, L.; Wilkinson, O.; Small, L.; Baldock, R.; Taylor, D.L.; Smith, D.; Bowler, L.D.; Morley, S.J.; Watts, F.Z.
The S. pombe translation initiation factor eIF4G is SUMOylated and associates with the SUMO protease Ulp2
PLoS ONE
9
e94182
2014
Schizosaccharomyces pombe
Manually annotated by BRENDA team
Ryu, H.Y.; Su, D.; Wilson-Eisele, N.R.; Zhao, D.; Lopez-Giraldez, F.; Hochstrasser, M.
The Ulp2 SUMO protease promotes transcription elongation through regulation of histone sumoylation
EMBO J.
38
e102003
2019
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Ryu, H.Y.; Wilson, N.R.; Mehta, S.; Hwang, S.S.; Hochstrasser, M.
Loss of the SUMO protease Ulp2 triggers a specific multichromosome aneuploidy
Genes Dev.
30
1881-1894
2016
Saccharomyces cerevisiae
Manually annotated by BRENDA team
de Albuquerque, C.P.; Suhandynata, R.T.; Carlson, C.R.; Yuan, W.T.; Zhou, H.
Binding to small ubiquitin-like modifier and the nucleolar protein Csm1 regulates substrate specificity of the Ulp2 protease
J. Biol. Chem.
293
12105-12119
2018
Saccharomyces cerevisiae (P40537)
Manually annotated by BRENDA team
Castro, P.H.; Santos, M.A.; Freitas, S.; Cana-Quijada, P.; Lourenco, T.; Rodrigues, M.A.A.; Fonseca, F.; Ruiz-Albert, J.; Azevedo, J.E.; Tavares, R.M.; Castillo, A.G.; Bejarano, E.R.; Azevedo, H.
Arabidopsis thaliana SPF1 and SPF2 are nuclear-located ULP2-like SUMO proteases that act downstream of SIZ1 in plant development
J. Exp. Bot.
69
4633-4649
2018
Arabidopsis thaliana (Q0WKV8), Arabidopsis thaliana (Q8L7S0)
Manually annotated by BRENDA team
Ryu, H.Y.; Lopez-Giraldez, F.; Knight, J.; Hwang, S.S.; Renner, C.; Kreft, S.G.; Hochstrasser, M.
Distinct adaptive mechanisms drive recovery from aneuploidy caused by loss of the Ulp2 SUMO protease
Nat. commun.
9
5417
2018
Saccharomyces cerevisiae
Manually annotated by BRENDA team