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3.4.22.B66: caspase-12

This is an abbreviated version!
For detailed information about caspase-12, go to the full flat file.

Word Map on EC 3.4.22.B66

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Synonyms

Casp12, caspase-12

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B66 caspase-12

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Resultsin table
1Activating Compound
3AA Sequence
1Application
551Disease/ Diagnostics
2Expression
11General Information
3Localization
2Molecular Weight [Da]
12Organism
1Protein Variants
12Reference
12Source Tissue
2Subunits
4Synonyms

Reference

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Reference on EC 3.4.22.B66 - caspase-12

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yi, J.Y.; Hirabayashi, Y.; Choi, Y.K.; Kodama, Y.; Kanno, J.; Han, J.H.; Inoue, T.; Yoon, B.I.
Benzene activates caspase-4 and -12 at the transcription level, without an association with apoptosis, in mouse bone marrow cells lacking the p53 gene
Arch. Toxicol.
83
795-803
2009
Mus musculus
Manually annotated by BRENDA team
Wang, P.; Arjona, A.; Zhang, Y.; Sultana, H.; Dai, J.; Yang, L.; LeBlanc, P.M.; Doiron, K.; Saleh, M.; Fikrig, E.
Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I
Nat. Immunol.
11
912-919
2010
Mus musculus
Manually annotated by BRENDA team
Li, L.; Cao, Z.; Jia, P.; Wang, Z.
Calcium signals and caspase-12 participated in paraoxon-induced apoptosis in EL4 cells
Toxicol. In Vitro
24
728-736
2010
Mus musculus
Manually annotated by BRENDA team
Liu, H.; Wang, Z.; Nowicki, M.J.
Caspase-12 mediates carbon tetrachloride-induced hepatocyte apoptosis in mice
World J. Gastroenterol.
20
18189-18198
2014
Mus musculus (O08736)
Manually annotated by BRENDA team
Ahn, Y.; Kim, M.; Chung, S.
Calpain and caspase-12 expression in lens epithelial cells of diabetic cataracts
Am. J. Ophthalmol.
167
31-37
2016
Homo sapiens
Manually annotated by BRENDA team
Zhang, Q.; Liu, J.; Chen, S.; Liu, J.; Liu, L.; Liu, G.; Wang, F.; Jiang, W.; Zhang, C.; Wang, S.; Yuan, X.
Caspase-12 is involved in stretch-induced apoptosis mediated endoplasmic reticulum stress
Apoptosis
21
432-442
2016
Rattus norvegicus (Q920D5)
Manually annotated by BRENDA team
Kamarehei, M.; Kabudanian Ardestani, S.; Firouzi, M.; Zahednasab, H.; Keyvani, H.; Harirchian, M.H.
Increased expression of endoplasmic reticulum stress-related caspase-12 and CHOP in the hippocampus of EAE mice
Brain Res. Bull.
147
174-182
2019
Mus musculus (O08736)
Manually annotated by BRENDA team
Song, J.; Zhang, Q.; Wang, S.; Yang, F.; Chen, Z.; Dong, Q.; Ji, Q.; Yuan, X.; Ren, D.
Cleavage of caspase-12 at Asp94, mediated by endoplasmic reticulum stress (ERS), contributes to stretch-induced apoptosis of myoblasts
J. Cell. Physiol.
233
9473-9487
2018
Mus musculus (O08736)
Manually annotated by BRENDA team
Skeldon, A.M.; Morizot, A.; Douglas, T.; Santoro, N.; Kursawe, R.; Kozlitina, J.; Caprio, S.; Mehal, W.Z.; Saleh, M.
Caspase-12, but not Caspase-11, inhibits obesity and insulin resistance
J. Immunol.
196
437-447
2016
Mus musculus (O08736), Mus musculus, Homo sapiens (Q6UXS9), Homo sapiens
Manually annotated by BRENDA team
Vande Walle, L.; Jimenez Fernandez, D.; Demon, D.; Van Laethem, N.; Van Hauwermeiren, F.; Van Gorp, H.; Van Opdenbosch, N.; Kayagaki, N.; Lamkanfi, M.
Does caspase-12 suppress inflammasome activation?
Nature
534
E1-E4
2016
Mus musculus (O08736)
Manually annotated by BRENDA team
Chu, W.K.; Hsu, C.C.; Huang, S.F.; Hsu, C.C.; Chow, S.E.
Caspase 12 degrades IkappaBalpha protein and enhances MMP-9 expression in human nasopharyngeal carcinoma cell invasion
Oncotarget
8
33515-33526
2017
Homo sapiens
Manually annotated by BRENDA team