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3.4.22.B66: caspase-12

This is an abbreviated version!
For detailed information about caspase-12, go to the full flat file.

Word Map on EC 3.4.22.B66

Reaction

Synonyms

Casp12, caspase-12

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B66 caspase-12

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Resultsin table
1Activating Compound
3AA Sequence
1Application
551Disease/ Diagnostics
2Expression
11General Information
3Localization
2Molecular Weight [Da]
12Organism
1Protein Variants
12Reference
12Source Tissue
2Subunits
4Synonyms

Expression

Expression on EC 3.4.22.B66 - caspase-12

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
activation of caspase-12 is detected in the liver at 12 and 24 h after carbon tetrachloride treatment
O,O-diethyl-O-4-nitrophenylphosphate up-regulates caspase-12 expression in a dose-dependent manner, and pre-treatment with EGTA, heparin or procaine significantly inhibits O,O-diethyl-O-4-nitrophenylphosphate-induced increase of caspase-12 expression. During the application of 5 nM POX for 0-8 h, caspase-12 expression increases significantly and continuously, and reaches the peak after 8 h treatment. However, caspase-12 expression after treatment with 5 nM POX for 16 h is similar to the control
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