3.4.22.B63: sortase C
This is an abbreviated version!
For detailed information about sortase C, go to the full flat file.
Word Map on EC 3.4.22.B63
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3.4.22.B63
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streptococcus
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pilins
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adhesin
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fimbriae
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actinomyces
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pyogenes
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shaft
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rrgc
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lpxtg
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transpeptidases
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agalactiae
-
piliated
-
coaggregation
- 3.4.22.B63
- streptococcus
- pilins
- adhesin
-
fimbriae
- actinomyces
- pyogenes
-
shaft
- rrgc
-
lpxtg
- transpeptidases
- agalactiae
-
piliated
-
coaggregation
Reaction
The enzyme from Bacillus anthracis cleaves the LPNT-/-A sorting signal of BasH and BasI, thereby anchoring both polypeptides to the cell wall envelope of sporulating bacilli [17074072]. The enzymes from Streptococcus pneumoniae and Enterococcus faecalis are required for efficient pilus assembly. =
Synonyms
pilus-associated sortase C, sortase C, sortase C1, sortase C2, sortaseC1, Srt-2, SrtC, SrtC-1, SrtC-2, SrtC-3, SrtC1, SrtC2, SrtC_1, SrtC_2, yhhA
ECTree
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Reference on EC 3.4.22.B63 - sortase C
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Neiers, F.; Madhurantakam, C.; Fälker, S.; Normark, S.; Henriques-Normark, B.; Achour, A.
Cloning, expression, purification, crystallization and preliminary X-ray analysis of the pilus-associated sortase C from Streptococcus pneumoniae
Acta Crystallogr. Sect. F
65
55-58
2009
Streptococcus pneumoniae
Barnett, T.C.; Patel, A.R.; Scott, J.R.
A novel sortase, SrtC2, from Streptococcus pyogenes anchors a surface protein containing a QVPTGV motif to the cell wall
J. Bacteriol.
186
5865-5875
2004
Streptococcus pyogenes
Marraffini, L.A.; Schneewind, O.
Sortase C-mediated anchoring of BasI to the cell wall envelope of Bacillus anthracis
J. Bacteriol.
189
6425-6436
2007
Bacillus anthracis
LeMieux, J.; Woody, S.; Camilli, A.
Roles of the sortases of Streptococcus pneumoniae in assembly of the RlrA pilus
J. Bacteriol.
190
6002-6013
2008
Streptococcus pneumoniae
Kline, K.A.; Kau, A.L.; Chen, S.L.; Lim, A.; Pinkner, J.S.; Rosch, J.; Nallapareddy, S.R.; Murray, B.E.; Henriques-Normark, B.; Beatty, W.; Caparon, M.G.; Hultgren, S.J.
Mechanism for sortase localization and role in efficient pilus assembly in Enterococcus faecalis
J. Bacteriol.
191
3237-3247
2009
Enterococcus faecalis
Nallapareddy, S.R.; Singh, K.V.; Sillanpää, J.; Garsin, D.A.; Höök, M.; Erlandsen, S.L.; Murray, B.E.
Endocarditis and biofilm-associated pili of Enterococcus faecalis
J. Clin. Invest.
116
2799-2807
2006
Enterococcus faecalis, Enterococcus faecalis OG1RF
Marraffini, L.A.; Schneewind, O.
Targeting proteins to the cell wall of sporulating Bacillus anthracis
Mol. Microbiol.
62
1402-1417
2006
Bacillus anthracis
Fälker, S.; Nelson, A.L.; Morfeldt, E.; Jonas, K.; Hultenby, K.; Ries, J.; Melefors, O.; Normark, S.; Henriques-Normark, B.
Sortase-mediated assembly and surface topology of adhesive pneumococcal pili
Mol. Microbiol.
70
595-607
2008
Streptococcus pneumoniae
Neiers, F.; Madhurantakam, C.; Faelker, S.; Manzano, C.; Dessen, A.; Normark, S.; Henriques-Normark, B.; Achour, A.
Two crystal structures of pneumococcal pilus sortase C provide novel insights into catalysis and substrate specificity
J. Mol. Biol.
393
704-716
2009
Streptococcus pneumoniae (A0A0H2UNU0), Streptococcus pneumoniae
Cozzi, R.; Malito, E.; Nuccitelli, A.; DOnofrio, M.; Martinelli, M.; Ferlenghi, I.; Grandi, G.; Telford, J.L.; Maione, D.; Rinaudo, C.D.
Structure analysis and site-directed mutagenesis of defined key residues and motives for pilus-related sortase C1 in group B Streptococcus
FASEB J.
25
1874-1886
2011
Streptococcus agalactiae (Q69EY7)
Khare, B.; Fu, Z.Q.; Huang, I.H.; Ton-That, H.; Narayana, S.V.
The crystal structure analysis of group B Streptococcus sortase C1: a model for the "lid" movement upon substrate binding
J. Mol. Biol.
414
563-577
2011
Streptococcus agalactiae serogroup V (Q8E0S7), Streptococcus agalactiae serogroup V ATCC BAA-611 (Q8E0S7)
Khare, B.; Krishnan, V.; Rajashankar, K.R.; I-Hsiu, H.; Xin, M.; Ton-That, H.; Narayana, S.V.
Structural differences between the Streptococcus agalactiae housekeeping and pilus-specific sortases: SrtA and SrtC1
PLoS ONE
6
e22995
2011
Streptococcus agalactiae, Streptococcus agalactiae 2603 V/R
Lu, G.; Qi, J.; Gao, F.; Yan, J.; Tang, J.; Gao, G.
A novel "open-form" structure of sortaseC from Streptococcus suis
Proteins
79
2764-2769
2011
Streptococcus suis (A4VY75), Streptococcus suis 05ZYH33 (A4VY75)
Cozzi, R.; Prigozhin, D.; Rosini, R.; Abate, F.; Bottomley, M.J.; Grandi, G.; Telford, J.L.; Rinaudo, C.D.; Maione, D.; Alber, T.
Structural basis for group B Streptococcus pilus 1 sortases C regulation and specificity
PLoS ONE
7
e49048
2012
Streptococcus agalactiae serogroup V (Q8E0S7), Streptococcus agalactiae serogroup V ATCC BAA-611 (Q8E0S7)
Oxaran, V.; Ledue-Clier, F.; Dieye, Y.; Herry, J.M.; Pechoux, C.; Meylheuc, T.; Briandet, R.; Juillard, V.; Piard, J.C.
Pilus biogenesis in Lactococcus lactis: molecular characterization and role in aggregation and biofilm formation
PLoS ONE
7
e50989
2012
Lactococcus lactis (Q9CHH2), Lactococcus lactis, Lactococcus lactis IL1403 (Q9CHH2)
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