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3.4.22.B63: sortase C

This is an abbreviated version!
For detailed information about sortase C, go to the full flat file.

Word Map on EC 3.4.22.B63

Reaction

The enzyme from Bacillus anthracis cleaves the LPNT-/-A sorting signal of BasH and BasI, thereby anchoring both polypeptides to the cell wall envelope of sporulating bacilli [17074072]. The enzymes from Streptococcus pneumoniae and Enterococcus faecalis are required for efficient pilus assembly. =

Synonyms

pilus-associated sortase C, sortase C, sortase C1, sortase C2, sortaseC1, Srt-2, SrtC, SrtC-1, SrtC-2, SrtC-3, SrtC1, SrtC2, SrtC_1, SrtC_2, yhhA

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B63 sortase C

Natural Substrates Products

Natural Substrates Products on EC 3.4.22.B63 - sortase C

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
BasH polypeptide + H2O
?
show the reaction diagram
-
sortase C cleaves the LPNTA sorting signal of BasH and BasI, thereby anchoring both polypeptides to the cell wall envelope of sporulating bacilli. Sortase C specifically recognizes and cleaves the LPNTA motif. SrtCDELTAN (with a replacement of the N-terminal signal peptide of sortase C for six histidy) cleaves peptides encompassing the LPNTA motif between threonine and alanine. Sortase C substrate BasH is expressed in the forespore
-
-
?
BasI polypeptide + H2O
?
show the reaction diagram
Dabcyl-ancillary protein 1-Edans + H2O
?
show the reaction diagram
Dabcyl-ancillary protein 2-Edans + H2O
?
show the reaction diagram
Dabcyl-BP-1 peptide-Edans + H2O
?
show the reaction diagram
surface protein containing a QVPTGV motif + H2O
?
show the reaction diagram
-
SrtC2 anchors a surface protein containing a QVPTGV motif (followed by a hydrophobic region and a charged tail) to the cell wall
-
-
?
additional information
?
-