3.4.22.B50: papain-like proteinase 2

This is an abbreviated version, for detailed information about papain-like proteinase 2, go to the full flat file.

Reaction

responsible for the cleavages located at the N-terminus of the replicase polyprotein =

Synonyms

Erv-C, ervatamin-C, mouse hepatitis virus papain-like proteinase 2, papain-like accessory proteases, papain-like cysteine proteinase, papain-like protease, papain-like protease domain 2, papain-like proteinase, PL2-PRO, PL2pro, PLP-2, PLP2, PLpro, SARS-coronavirus papain-like protease, SARS-CoV papain-like protease, SARS-CoV PLpro, severe acute respiratory syndrome coronavirus papain-like protease

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B50 papain-like proteinase 2

Reference

Reference on EC 3.4.22.B50 - papain-like proteinase 2

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Teng, H.; Pinon, J.D.; Weiss, S.R.
Expression of murine coronavirus recombinant papain-like proteinase: efficient cleavage is dependent on the lengths of both the substrate and the proteinase polypeptide
J. Virol.
73
2658-2666
1999
Murine coronavirus
Manually annotated by BRENDA team
Kanjanahaluethai, A.; Baker, S.C.
Identification of mouse hepatitis virus papain-like proteinase 2 activity
J. Virol.
74
7911-7921
2000
Murine coronavirus
Manually annotated by BRENDA team
Han, Y.S.; Chang, G.G.; Juo, C.G.; Lee, H.J.; Yeh, S.H.; Hsu, J.T.; Chen, X.
Papain-like protease 2 (PLP2) from severe acute respiratory syndrome coronavirus (SARS-CoV): expression, purification, characterization, and inhibition
Biochemistry
44
10349-10359
2005
Alphacoronavirus, Alphacoronavirus SARS-CoV
Manually annotated by BRENDA team
Kanjanahaluethai, A.; Baker, S.C.
Coronavirus papain-like endopeptidases
Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. )Academic Press
2
1265-1269
2004
Alphacoronavirus
-
Manually annotated by BRENDA team
Barretto, N.; Jukneliene, D.; Ratia, K.; Chen, Z.; Mesecar, A.D.; Baker, S.C.
The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity
J. Virol.
79
15189-15198
2005
Alphacoronavirus, Alphacoronavirus SARS-CoV
Manually annotated by BRENDA team
Lindner, H.A.; Fotouhi-Ardakani, N.; Lytvyn, V.; Lachance, P.; Sulea, T.; Menard, R.
The papain-like protease from the severe acute respiratory syndrome coronavirus is a deubiquitinating enzyme
J. Virol.
79
15199-15208
2005
Alphacoronavirus, Alphacoronavirus SARS-CoV
Manually annotated by BRENDA team
Ratia, K.; Saikatendu, K.S.; Santarsiero, B.D.; Barretto, N.; Baker, S.C.; Stevens, R.C.; Mesecar, A.D.
Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme
Proc. Natl. Acad. Sci. USA
103
5717-5722
2006
Alphacoronavirus, Alphacoronavirus SARS-CoV
Manually annotated by BRENDA team
Ziebuhr, J.; Schelle, B.; Karl, N.; Minskaia, E.; Bayer, S.; Siddell, S.G.; Gorbalenya, A.E.; Thiel, V.
Human coronavirus 229E papain-like proteases have overlapping specificities but distinct functions in viral replication
J. Virol.
81
3922-3932
2007
Human coronavirus 229E
Manually annotated by BRENDA team
Chen, Z.; Wang, Y.; Ratia, K.; Mesecar, A.D.; Wilkinson, K.D.; Baker, S.C.
Proteolytic processing and deubiquitinating activity of papain-like proteases of human coronavirus NL63
J. Virol.
81
6007-6018
2007
Human coronavirus NL63
Manually annotated by BRENDA team
Chaudhuri, R.; Tang, S.; Zhao, G.; Lu, H.; Case, D.A.; Johnson, M.E.
Comparison of SARS and NL63 papain-like protease binding sites and binding site dynamics: inhibitor design implications
J. Mol. Biol.
414
272-288
2011
Human coronavirus NL63
Manually annotated by BRENDA team
Wang, G.; Chen, G.; Zheng, D.; Cheng, G.; Tang, H.
PLP2 of mouse hepatitis virus A59 (MHV-A59) targets TBK1 to negatively regulate cellular type I interferon signaling pathway
PLoS ONE
6
e17192
2011
Murine hepatitis virus
Manually annotated by BRENDA team
Sun, L.; Yang, Y.; Liu, D.; Xing, Y.; Chen, X.; Chen, Z.
Deubiquitinase activity and regulation of antiviral innate immune responses by papain-like proteases of human coronavirus NL63
Prog. Biochem. Biophys.
37
871-880
2010
Human coronavirus NL63
-
Manually annotated by BRENDA team
Chou, C.Y.; Lai, H.Y.; Chen, H.Y.; Cheng, S.C.; Cheng, K.W.; Chou, Y.W.
Structural basis for catalysis and ubiquitin recognition by the severe acute respiratory syndrome coronavirus papain-like protease
Acta Crystallogr. Sect. D
70
572-581
2014
SARS coronavirus (P0C6U8), SARS coronavirus
Manually annotated by BRENDA team
Baez-Santos, Y.M.; St John, S.E.; Mesecar, A.D.
The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds
Antiviral Res.
115
21-38
2015
SARS coronavirus
Manually annotated by BRENDA team
Kong, L.; Shaw, N.; Yan, L.; Lou, Z.; Rao, Z.
Structural view and substrate specificity of papain-like protease from avian infectious bronchitis virus
J. Biol. Chem.
290
7160-7168
2015
infectious bronchitis virus (P0C6Y1)
Manually annotated by BRENDA team
Xing, Y.; Chen, J.; Tu, J.; Zhang, B.; Chen, X.; Shi, H.; Baker, S.C.; Feng, L.; Chen, Z.
The papain-like protease of porcine epidemic diarrhea virus negatively regulates type I interferon pathway by acting as a viral deubiquitinase
J. Gen. Virol.
94
1554-1567
2013
porcine epidemic diarrhea virus (P0C6Y4)
Manually annotated by BRENDA team
Dutta, S.; Dattagupta, J.K.; Biswas, S.
Enhancement of proteolytic activity of a thermostable papain-like protease by structure-based rational design
PLoS ONE
8
e62619
2013
Tabernaemontana divaricata (P83654), Tabernaemontana divaricata
Manually annotated by BRENDA team
van Kasteren, P.B.; Bailey-Elkin, B.A.; James, T.W.; Ninaber, D.K.; Beugeling, C.; Khajehpour, M.; Snijder, E.J.; Mark, B.L.; Kikkert, M.
Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells
Proc. Natl. Acad. Sci. USA
110
E838-E847
2013
equine arteritis virus (P19811)
Manually annotated by BRENDA team