3.4.22.B50: papain-like proteinase 2

This is an abbreviated version, for detailed information about papain-like proteinase 2, go to the full flat file.

Reaction

responsible for the cleavages located at the N-terminus of the replicase polyprotein =

Synonyms

Erv-C, ervatamin-C, mouse hepatitis virus papain-like proteinase 2, papain-like accessory proteases, papain-like cysteine proteinase, papain-like protease, papain-like protease domain 2, papain-like proteinase, PL2-PRO, PL2pro, PLP-2, PLP2, PLpro, SARS-coronavirus papain-like protease, SARS-CoV papain-like protease, SARS-CoV PLpro, severe acute respiratory syndrome coronavirus papain-like protease

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B50 papain-like proteinase 2

Natural Substrates Products

Natural Substrates Products on EC 3.4.22.B50 - papain-like proteinase 2

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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
FTKLAGGKISFS + H2O
FTKLAG + GKISFS
show the reaction diagram
-
-
-
-
?
polyubiquitin + H2O
monoubiquitin + ?
show the reaction diagram
P0C6Y1
the enzyme cleaves Lys48- and Lys63-linked polyubiquitin to monoubiquitin but not linear polyubiquitin
-
-
?
replicase polyprotein + H2O
?
show the reaction diagram
-
PLP2 cleaves a substrate encoding the first predicted membrane-spanning domain, MP1, of the replicase polyprotein. Processing the replicase polyprotein at this site generates the p150 replicase intermediate that is likely critical for embedding the replicase complex into cellular membranes. The enzyme acts efficiently in trans
-
-
?
ubiquitin + H2O
?
show the reaction diagram
ubiquitinated RIG-I + H2O
deubiquitinated RIG-I + ubiquitin
show the reaction diagram
P0C6Y4
-
-
-
?
ubiquitinated STING + H2O
deubiquitinated STING + ubiquitin
show the reaction diagram
P0C6Y4
-
-
-
?
VAKQGAGFKRTY + H2O
VAKQGA + GFKRTY
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
the enzyme is one of three distinct viral proteases (PLP1, PLP2 and 3CLpro) involved in processing of the replicase polyprotein
-
-
-