3.4.22.B50: papain-like proteinase 2

This is an abbreviated version, for detailed information about papain-like proteinase 2, go to the full flat file.

Reaction

responsible for the cleavages located at the N-terminus of the replicase polyprotein =

Synonyms

Erv-C, ervatamin-C, mouse hepatitis virus papain-like proteinase 2, papain-like accessory proteases, papain-like cysteine proteinase, papain-like protease, papain-like protease domain 2, papain-like proteinase, PL2-PRO, PL2pro, PLP-2, PLP2, PLpro, SARS-coronavirus papain-like protease, SARS-CoV papain-like protease, SARS-CoV PLpro, severe acute respiratory syndrome coronavirus papain-like protease

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B50 papain-like proteinase 2

KM Value

KM Value on EC 3.4.22.B50 - papain-like proteinase 2

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.021 - 0.0772
Abz-FRLKGGAPIKGV-N-(2,4-dinitrophenyl)-ethylenediamine
0.185
FRLKGGAPIKGV
-
-
0.09687 - 0.1769
N-benzoyl-Phe-Val-Arg-4-nitroanilide
0.73 - 3.33
ubiquitin-7-amido-4-trifluoromethylcoumarin
-
3.23
Z-KKAG-7-amido-4-methylcoumarin
in 20 mM Tris-HCl, pH 7.5, 0.1 mg/ml BSA, 150 mM NaCl, 2 mM dithiothreitol, at 25°C
0.67
Z-LRGG-7-amido-4-methylcoumarin
in 20 mM Tris-HCl, pH 7.5, 0.1 mg/ml BSA, 150 mM NaCl, 2 mM dithiothreitol, at 25°C
additional information
additional information
Michaelis-Menten steady-state enzyme-kinetics of wild-type and mutant enzymes, overview
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