3.4.22.B50: papain-like proteinase 2
This is an abbreviated version!
For detailed information about papain-like proteinase 2, go to the full flat file.
Word Map on EC 3.4.22.B50
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3.4.22.B50
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polyproteins
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replicase
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coronaviruses
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3clpro
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isg15
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3c-like
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mhv-a59
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nsp3
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coronaviral
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pp1ab
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medicine
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drug development
- 3.4.22.B50
- polyproteins
-
replicase
- coronaviruses
- 3clpro
- isg15
-
3c-like
-
mhv-a59
- nsp3
- coronaviral
- pp1ab
- medicine
- drug development
Reaction
responsible for the cleavages located at the N-terminus of the replicase polyprotein =
Synonyms
Erv-C, ervatamin-C, mouse hepatitis virus papain-like proteinase 2, papain-like accessory protease, papain-like cysteine proteinase, papain-like protease, papain-like protease domain 2, papain-like proteinase, PL2-PRO, PL2pro, PLP-2, PLP2, PLpro, SARS-coronavirus papain-like protease, SARS-CoV papain-like protease, SARS-CoV PLpro, severe acute respiratory syndrome coronavirus papain-like protease
ECTree
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Inhibitors
Inhibitors on EC 3.4.22.B50 - papain-like proteinase 2
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(4E)-1,7-bis(3,4-dihydroxyphenyl)hept-4-en-3-one
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a natural diarylheptanoide inhibitor
(7R)-5,7-dihydroxy-8-(4-hydroxy-3-methoxyphenyl)-2-(4-hydroxy-4-methylpentyl)-2-methyl-3,4,7,8-tetrahydro-2H,6H-pyrano[3,2-g]chromen-6-one
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a natural geranylated flavonoid inhibitor
1,6,6-trimethyl-1,2,6,7,8,9-hexahydrophenanthro[1,2-b]furan-10,11-dione
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a natural tanshinone inhibitor
2-methyl-N-[(1R)-1-(naphthalen-2-yl)ethyl]benzamide
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over 90% inhibition at 0.1 mM
2-methyl-N-[(1S)-1-(naphthalen-2-yl)ethyl]benzamide
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14% inhibition at 0.1 mM
2-methyl-N-[1-(naphthalen-2-yl)ethyl]benzamide
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racemat
5-amino-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]benzamide
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R-isomer, a potent, noncovalent, competitive inhibitor
N-(1,3-benzodioxol-5-ylmethyl)-1-[(1R)-1-(naphthalen-1-yl)ethyl]piperidine-4-carboxamide
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N-(3-fluorobenzyl)-1-[(1R)-1-(naphthalen-1-yl)ethyl]piperidine-4-carboxamide
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N-(4-fluorobenzyl)-1-[(1R)-1-(naphthalen-1-yl)ethyl]piperidine-4-carboxamide
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N-(4-methoxybenzyl)-1-(naphthalen-1-ylmethyl)piperidine-4-carboxamide
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N-cyclohexyl-2-aminethanesulfonic acid
the molecule binds near the catalytic triad
N-ethyl-N-phenyldithiocarbamic acid-Zn(II)
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N-[(2-methoxypyridin-4-yl)methyl]-1-[(1R)-1-(naphthalen-1-yl)ethyl]piperidine-4-carboxamide
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N-[3-(acetylamino)benzyl]-1-[(1R)-1-(naphthalen-1-yl)ethyl]piperidine-4-carboxamide
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Ub-3Br
suicide inhibitor, i.e. ubiquitin(1-75)-3-bromopropylamide
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6-Mercaptopurine
competitive and reversible inhibitor
6-thioguanine
competitive and reversible inhibitor
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not inhibited by Mg2+, Mn2+, Ca2+, Ni2+ and Co2+ at 0.01 mM, E64, leupeptin and antipain at 0.1 mM, N-ethylmaleimide and chymostatin at 1 mM and cystatin at 0.01 mg/mL respectively
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additional information
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not sensitive to cysteine protease inhibitor E-64d
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additional information
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not sensitive to cysteine protease inhibitor E64d
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additional information
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enzyme structure, function and inhibition by designed antiviral compounds, overview. No inhibition by NSC158362. Selectivity of naphthalene-based enzyme inhibitors, overview
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