3.4.22.B50: papain-like proteinase 2

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For detailed information about papain-like proteinase 2, go to the full flat file.

Reaction

responsible for the cleavages located at the N-terminus of the replicase polyprotein =

Synonyms

Erv-C, ervatamin-C, mouse hepatitis virus papain-like proteinase 2, papain-like accessory protease, papain-like cysteine proteinase, papain-like protease, papain-like protease domain 2, papain-like proteinase, PL2-PRO, PL2pro, PLP-2, PLP2, PLpro, SARS-coronavirus papain-like protease, SARS-CoV papain-like protease, SARS-CoV PLpro, severe acute respiratory syndrome coronavirus papain-like protease

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.B50 papain-like proteinase 2

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Results	in table
1	Activating Compound
5	AA Sequence
10	Application
1	CAS Registry Number
12	Cloned(Commentary)
6	Crystallization (Commentary)
11	General Information
22	IC50 Value
35	Inhibitors
22	kcat/KM [mM/s]
5	Ki Value [mM]
28	KM Value [mM]
1	Localization
2	Metals/Ions
8	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
39	Organism
3	pH Optimum
1	pH Range
32	Protein Variants
7	Purification (Commentary)
2	Reaction
1	Reaction Type
26	Reference
1	Renatured (Commentary)
4	Specific Activity [micromol/min/mg]
3	Storage Stability
56	Substrates and Products (Substrate)
5	Subunits
38	Synonyms
2	Temperature Optimum [°C]
2	Temperature Stability [°C]
25	Turnover Number [1/s]

Application

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Application on EC 3.4.22.B50 - papain-like proteinase 2

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

drug development

Severe acute respiratory syndrome-related coronavirus

-

the enzyme is an attractive antiviral drug target because it is essential for coronaviral replication. Targeting the enzyme with antiviral drugs may have an advantage in not only inhibiting viral replication but also inhibiting the dysregulation of signaling cascades in infected cells that may lead to cell death in surrounding, uninfected cells

731149

medicine

9 entries

medicine

Alphacoronavirus

-

antiviral therapy

667619

medicine

Alphacoronavirus

-

PLpro is an important target for development of antiviral drugs that would inhibit viral replication and reduce mortality associated with outbreaks of SARS-CoV

670702

medicine

Alphacoronavirus

-

viral strategy to modulate the host cell ubiquitination machinery to its advantage

670085

medicine

Human coronavirus NL63

-

the enzyme is a potential targets for antiviral drug development

718000

medicine

equine arteritis virus

P19811

vaccination of Shetland mares, either with deubiquitinase DUB-positive or DUB-negative recombinant equine arteritis virus. Upon challenge with the virulent KY84 strain of equine arteritis virus, both vaccine viruses proved to be replication competent in vivo. The DUB-negative virus provides a similar degree of protection against clinical disease as its DUB-positive parental counterpart. A possible improvement due to inactivation of PLP2 DUB activity could not be detected under these experimental conditions

755638

medicine

equine arteritis virus Bucyrus

-

vaccination of Shetland mares, either with deubiquitinase DUB-positive or DUB-negative recombinant equine arteritis virus. Upon challenge with the virulent KY84 strain of equine arteritis virus, both vaccine viruses proved to be replication competent in vivo. The DUB-negative virus provides a similar degree of protection against clinical disease as its DUB-positive parental counterpart. A possible improvement due to inactivation of PLP2 DUB activity could not be detected under these experimental conditions

-

medicine

Alphacoronavirus SARS-CoV

-

antiviral therapy

-

medicine

Alphacoronavirus SARS-CoV

-

viral strategy to modulate the host cell ubiquitination machinery to its advantage

-

medicine

Alphacoronavirus SARS-CoV

-

PLpro is an important target for development of antiviral drugs that would inhibit viral replication and reduce mortality associated with outbreaks of SARS-CoV

-