3.4.22.B49: cathepsin L1

This is an abbreviated version!
For detailed information about cathepsin L1, go to the full flat file.

Reaction

clear preference for Arg at P1 position (Lys, Glu, Thr, and Met are less efficient). FheCL1 shows distinct preference for hydrophobic amino acids in the P2, Leu is favored. Cathepsin L1 can accommodate Pro in the P2 position, but less efficiently than cathepsin L2. FheCL1 produces clear degradation fragments from collagen =

Synonyms

cat-L1H, cathepsin L1, cathepsin L1 cysteine protease, cathepsin L1 protease, cathepsin L1 proteinase, cathepsin L1g, cathepsin L1H, CatL1, CgCTSL1, CGI_10027418, CL1, CPFhW, CTSL1, cysteine proteinase 3, Da-CTSL1, FgCatL1H, FhCL1, FheCL1, FhpCL1

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.B49 cathepsin L1

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Results	in table
7	Activating Compound
14	AA Sequence
18	Application
1	CAS Registry Number
22	Cloned(Commentary)
1	Crystallization (Commentary)
83	Disease/ Diagnostics
3	Expression
8	General Information
39	IC50 Value
66	Inhibitors
6	Ki Value [mM]
44	KM Value [mM]
6	Localization
16	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
42	Organism
6	pH Optimum
4	pH Range
5	pH Stability
2	pI Value
7	Posttranslational Modification
10	Protein Variants
21	Purification (Commentary)
1	Reaction
1	Reaction Type
40	Reference
2	Renatured (Commentary)
29	Source Tissue
2	Specific Activity [micromol/min/mg]
74	Substrates and Products (Substrate)
14	Subunits
54	Synonyms
3	Temperature Optimum [°C]
1	Temperature Stability [°C]
43	Turnover Number [1/s]

pH Range

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pH Range on EC 3.4.22.B49 - cathepsin L1

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

3 - 9

Fasciola hepatica

-

the enzyme has the capacity to cleave substrates over a wide pH range

694804

5.5 - 10

Diaprepes abbreviatus

Q0PZI4

activity range, profile overview. 8Fold higher activity at pH 8.0 as compared to pH 5.5 with substrate N-benzyloxycarbonyl-GPR-7-amido-4-methylcoumarin, Da-CTSL1 is a mainly alkaline cathepsin

754348

5.5 - 7

Fasciola hepatica

-

substrate ovalbumin

694804

6 - 8

Fasciola hepatica

-

-

669216