3.4.22.B49: cathepsin L1
This is an abbreviated version!
For detailed information about cathepsin L1, go to the full flat file.
Word Map on EC 3.4.22.B49
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3.4.22.B49
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cathepsins
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fasciola
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hepatica
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fluke
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fasciolosis
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metacercariae
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helminth
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gigantica
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medicine
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excysted
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trematode
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excretory-secretory
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immunodiagnosis
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agriculture
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mimotopes
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diagnostics
- 3.4.22.B49
- cathepsins
- fasciola
- hepatica
- fluke
-
fasciolosis
-
metacercariae
-
helminth
- gigantica
- medicine
-
excysted
-
trematode
-
excretory-secretory
-
immunodiagnosis
- agriculture
-
mimotopes
- diagnostics
Reaction
clear preference for Arg at P1 position (Lys, Glu, Thr, and Met are less efficient). FheCL1 shows distinct preference for hydrophobic amino acids in the P2, Leu is favored. Cathepsin L1 can accommodate Pro in the P2 position, but less efficiently than cathepsin L2. FheCL1 produces clear degradation fragments from collagen =
Synonyms
cat-L1H, cathepsin L1, cathepsin L1 cysteine protease, cathepsin L1 protease, cathepsin L1 proteinase, cathepsin L1g, cathepsin L1H, CatL1, CgCTSL1, CGI_10027418, CL1, CPFhW, CTSL1, cysteine proteinase 3, Da-CTSL1, FgCatL1H, FhCL1, FheCL1, FhpCL1
ECTree
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Source Tissue
Source Tissue on EC 3.4.22.B49 - cathepsin L1
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phagocytic hemocytes, cathepsin L1 is highly expressed in phagocytes
additional information
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the slightly acidic pH value of gut facilitates auto-activation of the inactive zymogen proCL1
high enzyme content, proteolytic activity and distribution of CgCTSL1 in different subpopulations of hemocytes, distribution of CgCTSL1 in phagocytes and non-phagocytic hemocytes, overview
CL1 belongs to a variety of cysteine proteases that are extensively expressed in the Fasciola species
additional information
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CL1 belongs to a variety of cysteine proteases that are extensively expressed in the Fasciola species
additional information
Fasciola gigantica cathepsin L1H (FgCatL1H) is the isotype expressed in the early stages for migration and invasion. Immunohistochemic analysis of adult and juvenile stages
additional information
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Fasciola gigantica cathepsin L1H (FgCatL1H) is the isotype expressed in the early stages for migration and invasion. Immunohistochemic analysis of adult and juvenile stages
additional information
CL1 belongs to a variety of cysteine proteases that are extensively expressed in the Fasciola species