3.4.22.B49: cathepsin L1
This is an abbreviated version!
For detailed information about cathepsin L1, go to the full flat file.
Word Map on EC 3.4.22.B49
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3.4.22.B49
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cathepsins
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fasciola
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hepatica
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fluke
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fasciolosis
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metacercariae
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helminth
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gigantica
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medicine
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excysted
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trematode
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excretory-secretory
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immunodiagnosis
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agriculture
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mimotopes
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diagnostics
- 3.4.22.B49
- cathepsins
- fasciola
- hepatica
- fluke
-
fasciolosis
-
metacercariae
-
helminth
- gigantica
- medicine
-
excysted
-
trematode
-
excretory-secretory
-
immunodiagnosis
- agriculture
-
mimotopes
- diagnostics
Reaction
clear preference for Arg at P1 position (Lys, Glu, Thr, and Met are less efficient). FheCL1 shows distinct preference for hydrophobic amino acids in the P2, Leu is favored. Cathepsin L1 can accommodate Pro in the P2 position, but less efficiently than cathepsin L2. FheCL1 produces clear degradation fragments from collagen =
Synonyms
cat-L1H, cathepsin L1, cathepsin L1 cysteine protease, cathepsin L1 protease, cathepsin L1 proteinase, cathepsin L1g, cathepsin L1H, CatL1, CgCTSL1, CGI_10027418, CL1, CPFhW, CTSL1, cysteine proteinase 3, Da-CTSL1, FgCatL1H, FhCL1, FheCL1, FhpCL1
ECTree
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Reference on EC 3.4.22.B49 - cathepsin L1
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dowd, A.J.; Smith, A.M.; McGonigle, S.; Dalton, J.P.
Purification and characterization of a second cathepsin L proteinase secreted by parasitic trematode Fasciola hepatica
Eur. J. Biochem.
223
91-98
1994
Fasciola hepatica
Smith, A.M.; Dowd, A.J.; McGonigle, S.; Keegan, P.S.; Brennan, G.; Trudgett, A.; Dalton, J.P.
Purification of a cathepsin L-like proteinase secreted by adult Fasciola hepatica
Mol. Biochem. Parasitol.
62
1-8
1993
Fasciola hepatica
Cordova, M.; Jara, J.; Del Nery, E.; Hirata, I.Y.; Araujo, M.S.; Carmona, A.K.; Juliano, M.A.; Juliano, L.
Characterization of two cysteine proteinases secreted by Fasciola hepatica and demonstration of their kininogenase activity
Mol. Biochem. Parasitol.
116
109-115
2001
Fasciola hepatica
Dalton, J.P.; Neill, S.O.; Stack, C.; Collins, P.; Walshe, A.; et al.
Fasciola hepatica cathepsin L-like protease: biology, function, and potential in the development of the first generation liver fluke vaccines
Int. J. Parasitol.
33
1173-1181
2003
Fasciola hepatica
Kuk, S.; Kaplan, M.; Ozdarendeli, A.; Tonbak, S.; Felek, S.; Kalkan, A.
Fasciola hepatica cathepsin L1 from a Turkish isolate is related to Asiatic isolates
Acta Parasitol.
50
244-248
2005
Fasciola hepatica (Q2HPD3), Fasciola hepatica (Q7KYH5), Fasciola gigantica (Q8MUT6), Fasciola gigantica (Q9XYL8)
-
Ruth, D.M.; McMahon, G.; O'Fagain, C.
Peptide synthesis by recombinant Fasciola hepatica cathepsin L1
Biochimie
88
117-120
2006
Fasciola hepatica
Intapan, P.; Tantrawatpan, C.; Maleewong, W.; Wongkham, S.; Wongkham, C.; Nakashima, K.
Potent epitopes derived from cathepsin L1 in peptide-based immunoassay for the serodiagnosis of human fascioliasis
Diagn. Microbiol. Infect. Dis.
53
125-129
2005
Fasciola gigantica
Collins, P.R.; Stack, C.M.; ONeill, S.M.; Doyle, S.; Ryan, T.; Brennan, G.P.; Mousley, A.; Stewart, M.; Maule, A.G.; Dalton, J.P.; Donnelly, S.
Cathepsin L1, the major protease involved in liver fluke (Fasciola hepatica) virulence: propetide cleavage sites and autoactivation of the zymogen secreted from gastrodermal cells
J. Biol. Chem.
279
17038-17046
2004
Fasciola hepatica
Stack, C.M.; Donnelly, S.; Lowther, J.; Xu, W.; Collins, P.R.; Brinen, L.S.; Dalton, J.P.
The major secreted cathepsin L1 protease of the liver fluke, Fasciola hepatica: a Leu-12 to Pro-12 replacement in the nonconserved C-terminal region of the prosegment prevents complete enzyme autoactivation and allows definition of the molecular events in
J. Biol. Chem.
282
16532-16543
2007
Fasciola hepatica
Stack, C.M.; Caffrey, C.R.; Donnelly, S.M.; Seshaadri, A.; Lowther, J.; Tort, J.F.; Collins, P.R.; Robinson, M.W.; Xu, W.; McKerrow, J.H.; Craik, C.S.; Geiger, S.R.; Marion, R.; Brinen, L.S.; Dalton, J.P.
Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica
J. Biol. Chem.
283
9896-9908
2008
Fasciola hepatica (Q24940), Fasciola hepatica
Kesik, M.; Jedlina-Panasiuk, L.; Kozak-Cieszczyk, M.; P?ucienniczak, A.; Wedrychowicz, H.
Enteral vaccination of rats against Fasciola hepatica using recombinant cysteine proteinase (cathepsin L1)
Vaccine
25
3619-3628
2007
Fasciola hepatica
Berasain, P.; Carmona, C.; Frangione, B.; Dalton, J.P.; Goni, F.
Fasciola hepatica: parasite-secreted proteinases degrade all human IgG subclasses: determination of the specific cleavage sites and identification of the immunoglobulin fragments produced
Exp. Parasitol.
94
99-110
2000
Fasciola hepatica
Lowther, J.; Robinson, M.W.; Donnelly, S.M.; Xu, W.; Stack, C.M.; Matthews, J.M.; Dalton, J.P.
The importance of pH in regulating the function of the Fasciola hepatica cathepsin L1 cysteine protease
PLoS Negl. Trop. Dis.
3
e369
2009
Fasciola hepatica
Robinson, M.W.; Dalton, J.P.; Donnelly, S.
Helminth pathogen cathepsin proteases
Trends Biochem. Sci.
33
601-608
2008
Fasciola hepatica (Q24940)
Jayaraj, R.; Piedrafita, D.; Dynon, K.; Grams, R.; Spithill, T.W.; Smooker, P.M.
Vaccination against fasciolosis by a multivalent vaccine of stage-specific antigens
Vet. Parasitol.
160
230-236
2009
Fasciola hepatica
Robinson, M.W.; Tort, J.F.; Lowther, J.; Donnelly, S.M.; Wong, E.; Xu, W.; Stack, C.M.; Padula, M.; Herbert, B.; Dalton, J.P.
Proteomics and phylogenetic analysis of the cathepsin L protease family of the helminth pathogen Fasciola hepatica: expansion of a repertoire of virulence-associated factors
Mol. Cell. Proteomics
7
1111-1123
2008
Fasciola hepatica (Q7JNQ9)
Villa-Mancera, A.; Quiroz-Romero, H.; Correa, D.; Ibarra, F.; Reyes-Perez, M.; Reyes-Vivas, H.; Lopez-Velazquez, G.; Gazarian, K.; Gazarian, T.; Alonso, R.A.
Induction of immunity in sheep to Fasciola hepatica with mimotopes of cathepsin L selected from a phage display library
Parasitology
135
1437-1445
2008
Fasciola hepatica
Ma, J.; Zhang, D.; Jiang, J.; Cui, S.; Pu, H.; Jiang, S.
Molecular characterization and expression analysis of cathepsin L1 cysteine protease from pearl oyster Pinctada fucata
Fish Shellfish Immunol.
29
501-507
2010
Pinctada fucata (D3XLA0), Pinctada fucata
Moran, B.W.; Anderson, F.P.; Ruth, D.M.; Fagain, C.O.; Dalton, J.P.; Kenny, P.T.
Fluorobenzoyl dipeptidyl derivatives as inhibitors of the Fasciola hepatica cysteine protease cathepsin L1
J. Enzyme Inhib. Med. Chem.
25
1-12
2010
Fasciola hepatica
Miysato, P.; Ramos, C.; Abreu, P.; Dias, W.; Nascimento, C.; Ho, P.; Kawano, T.
Expression of schistosomal cathepsin L1 in Escherichia coli and evaluation of its protective capacity in an animal challenge
J. Venom. Anim. Toxins incl. Trop. Dis.
15
289-304
2009
Schistosoma mansoni (Q26534)
-
Golden, O.; Flynn, R.J.; Read, C.; Sekiya, M.; Donnelly, S.M.; Stack, C.; Dalton, J.P.; Mulcahy, G.
Protection of cattle against a natural infection of Fasciola hepatica by vaccination with recombinant cathepsin L1 (rFhCL1)
Vaccine
28
5551-5557
2010
Fasciola hepatica
Perez-Ecija, R.A.; Mendes, R.E.; Zafra, R.; Buffonni, L.; Martinez-Moreno, A.; Perez, J.
Pathological and parasitological protection in goats immunised with recombinant cathepsin L1 and challenged with Fasciola hepatica
Vet. J.
185
351-353
2010
Fasciola hepatica
Kim, Y.O.; Park, E.M.; Seo, J.S.; Nam, B.H.; Kong, H.J.; Kim, W.J.; Kim, B.S.; Kim, K.K.; Lee, S.J.
Molecular cloning and mRNA expression of the liver-specific cathepsin L1 gene of the olive flounder, Paralichthys olivaceus
Biosci. Biotechnol. Biochem.
75
1214-1218
2011
Paralichthys olivaceus
Buffoni, L.; Martinez-Moreno, F.J.; Zafra, R.; Mendes, R.E.; Perez-Ecija, A.; Sekiya, M.; Mulcahy, G.; Perez, J.; Martinez-Moreno, A.
Humoral immune response in goats immunised with cathepsin L1, peroxiredoxin and Sm14 antigen and experimentally challenged with Fasciola hepatica
Vet. Parasitol.
185
315-321
2012
Fasciola hepatica
Anuracpreeda, P.; Srirakam, T.; Pandonlan, S.; Changklungmoa, N.; Chotwiwatthanakun, C.; Tinikul, Y.; Poljaroen, J.; Meemon, K.; Sobhon, P.
Production and characterization of a monoclonal antibody against recombinant cathepsin L1 of Fasciola gigantica
Acta Trop.
136
1-9
2014
Fasciola gigantica
Hernandez-Guzman, K.; Sahagun-Ruiz, A.; Vallecillo, A.J.; Cruz-Mendoza, I.; Quiroz-Romero, H.
Construction and evaluation of a chimeric protein made from Fasciola hepatica leucine aminopeptidase and cathepsin L1
J. Helminthol.
90
7-13
2016
Fasciola hepatica (Q9GRW5), Fasciola hepatica
Ben-Mahmoud, S.; Ramos, J.E.; Shatters, R.G.; Rouge, P.; Powell, C.A.; Smagghe, G.; Borovsky, D.
Cloning and characterization of a basic cysteine-like protease (cathepsin L1) expressed in the gut of larval Diaprepes abbreviatus L. (Coleoptera: Curculionidae)
J. Insect Physiol.
72
1-13
2015
Diaprepes abbreviatus
Kueakhai, P.; Changklungmoa, N.; Chaichanasak, P.; Jaikua, W.; Itagaki, T.; Sobhon, P.
Vaccine potential of recombinant pro- and mature cathepsin L1 against fasciolosis gigantica in mice
Acta Trop.
150
71-78
2015
Fasciola gigantica (Q9XYL8), Fasciola gigantica
Lv, Z.; Qiu, L.; Liu, Z.; Wang, W.; Chen, H.; Jia, Y.; Jia, Z.; Jiang, S.; Wang, L.; Song, L.
Molecular characterization of a cathepsin L1 highly expressed in phagocytes of pacific oyster Crassostrea gigas
Dev. Comp. Immunol.
89
152-162
2018
Crassostrea gigas (K1QEW8), Crassostrea gigas
Meshgi, B.; Jalousian, F.; Fathi, S.; Jahani, Z.
Design and synthesis of a new peptide derived from Fasciola gigantica cathepsin L1 with potential application in serodiagnosis of fascioliasis
Exp. Parasitol.
189
76-86
2018
Fasciola hepatica (Q24940), Fasciola gigantica (Q9XYL8), Fasciola gigantica
Hernandez-Guzman, K.; Sahagun-Ruiz, A.; Vallecillo, A.; Cruz-Mendoza, I.; Quiroz-Romero, H.
Construction and evaluation of a chimeric protein made from Fasciola hepatica leucine aminopeptidase and cathepsin L1
J. Helminthol.
90
7-13
2016
Fasciola hepatica (Q9GRW5), Fasciola hepatica
Ben-Mahmoud, S.; Ramos, J.; Shatters, R.; Rouge, P.; Powell, C.; Smagghe, G.; Borovsky, D.
Cloning and characterization of a basic cysteine-like protease (cathepsin L1) expressed in the gut of larval Diaprepes abbreviatus L. (Coleoptera Curculionidae)
J. Insect Physiol.
72
1-13
2015
Diaprepes abbreviatus (Q0PZI4), Diaprepes abbreviatus
Mebius, M.M.; Op Heij, J.M.J.; Tielens, A.G.M.; de Groot, P.G.; Urbanus, R.T.; van Hellemond, J.J.
Fibrinogen and fibrin are novel substrates for Fasciola hepatica cathepsin L peptidases
Mol. Biochem. Parasitol.
221
10-13
2018
Fasciola hepatica (H8WG11), Fasciola hepatica
Wongwairot, S.; Kueakhai, P.; Changklungmoa, N.; Jaikua, W.; Sansri, V.; Meemon, K.; Songkoomkrong, S.; Riengrojpitak, S.; Sobhon, P.
Monoclonal antibody against recombinant Fasciola gigantica cathepsin L1H could detect juvenile and adult cathepsin Ls of Fasciola gigantica
Parasitol. Res.
114
133-140
2015
Fasciola gigantica (Q6T857), Fasciola gigantica
Martinez-Sernandez, V.; Perteguer, M.J.; Hernandez-Gonzalez, A.; Mezo, M.; Gonzalez-Warleta, M.; Orbegozo-Medina, R.A.; Romaris, F.; Paniagua, E.; Garate, T.; Ubeira, F.M.
Comparison of recombinant cathepsins L1, L2, and L5 as ELISA targets for serodiagnosis of bovine and ovine fascioliasis
Parasitol. Res.
117
1521-1534
2018
Fasciola hepatica (H8WG11)
Nandy, S.K.; Seal, A.
Structural dynamics investigation of human family 1 & 2 cystatin-cathepsin L1 interaction a comparison of binding modes
PLoS ONE
11
e0164970
2016
Homo sapiens (P07711), Homo sapiens
Sansri, V.; Meemon, K.; Changklungmoa, N.; Kueakhai, P.; Chantree, P.; Chaichanasak, P.; Lorsuwannarat, N.; Itagaki, T.; Sobhon, P.
Protection against Fasciola gigantica infection in mice by vaccination with recombinant juvenile-specific cathepsin L
Vaccine
33
1596-1601
2015
Fasciola gigantica (Q6T857), Fasciola gigantica
Ortega-Vargas, S.; Espitia, C.; Sahagun-Ruiz, A.; Parada, C.; Balderas-Loaeza, A.; Villa-Mancera, A.; Quiroz-Romero, H.
Moderate protection is induced by a chimeric protein composed of leucine aminopeptidase and cathepsin L1 against Fasciola hepatica challenge in sheep
Vaccine
37
3234-3240
2019
Fasciola hepatica (Q9GRW5), Fasciola hepatica
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