3.4.22.B49: cathepsin L1

This is an abbreviated version!
For detailed information about cathepsin L1, go to the full flat file.

Reaction

clear preference for Arg at P1 position (Lys, Glu, Thr, and Met are less efficient). FheCL1 shows distinct preference for hydrophobic amino acids in the P2, Leu is favored. Cathepsin L1 can accommodate Pro in the P2 position, but less efficiently than cathepsin L2. FheCL1 produces clear degradation fragments from collagen =

Synonyms

cat-L1H, cathepsin L1, cathepsin L1 cysteine protease, cathepsin L1 protease, cathepsin L1 proteinase, cathepsin L1g, cathepsin L1H, CatL1, CgCTSL1, CGI_10027418, CL1, CPFhW, CTSL1, cysteine proteinase 3, Da-CTSL1, FgCatL1H, FhCL1, FheCL1, FhpCL1

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.B49 cathepsin L1

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
7	Activating Compound
14	AA Sequence
18	Application
1	CAS Registry Number
22	Cloned(Commentary)
1	Crystallization (Commentary)
83	Disease/ Diagnostics
3	Expression
8	General Information
39	IC50 Value
66	Inhibitors
6	Ki Value [mM]
44	KM Value [mM]
6	Localization
16	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
42	Organism
6	pH Optimum
4	pH Range
5	pH Stability
2	pI Value
7	Posttranslational Modification
10	Protein Variants
21	Purification (Commentary)
1	Reaction
1	Reaction Type
40	Reference
2	Renatured (Commentary)
29	Source Tissue
2	Specific Activity [micromol/min/mg]
74	Substrates and Products (Substrate)
14	Subunits
54	Synonyms
3	Temperature Optimum [°C]
1	Temperature Stability [°C]
43	Turnover Number [1/s]

Inhibitors

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Inhibitors on EC 3.4.22.B49 - cathepsin L1

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Inhibitor Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

Aprotinin

2 entries

benzyloxycarbonyl-L-phenylalanyl-L-alanine-diazomethylketone(-CHN2)

Fasciola hepatica

-

-

669216

Benzyloxycarbonyl-Phe-Ala-CHN2

Fasciola hepatica

-

-

709299

benzyloxycarbonyl-Phe-Ala-diazomethyl ketone

Fasciola hepatica

Q24940

FheCL1

680930

CA074

2 entries

cathepsin K inhibitor II

Fasciola hepatica

Q24940

FheCL1

680930

chymostatin

2 entries

cystatin

2 entries

-

cystatin C

Homo sapiens

P07711

-

755132

-

cystatin D

Homo sapiens

P07711

-

755132

-

cystatin F

Homo sapiens

P07711

-

755132

-

cystatin M/E

Homo sapiens

P07711

-

755132

-

Cystatin S

Homo sapiens

P07711

-

755132

-

cystatin SA

Homo sapiens

P07711

-

755132

-

cystatin SN

Homo sapiens

P07711

-

755132

-

E-64

2 entries

N-2,3,4,5,6-pentafluorobenzoyl-L-leucyl-glycine nitrile

Fasciola hepatica

-

-

709299

N-2,3,4,5-tetrafluorobenzoyl-L-leucyl-glycine nitrile

Fasciola hepatica

-

-

709299

N-2,3,4-trifluorobenzoyl-L-leucyl-glycine nitrile

Fasciola hepatica

-

-

709299

N-2,3,6-trifluorobenzoyl-L-leucyl-glycine nitrile

Fasciola hepatica

-

-

709299

N-2,3-difluorobenzoyl-L-leucyl-glycine nitrile

Fasciola hepatica

-

-

709299

N-2,4,5-trifluorobenzoyl-L-leucyl-glycine nitrile

Fasciola hepatica

-

-

709299

N-2,4-difluorobenzoyl-L-leucyl-glycine nitrile

Fasciola hepatica

-

-

709299

N-2,5-difluorobenzoyl-L-leucyl-glycine nitrile

Fasciola hepatica

-

-

709299

N-2,6-difluorobenzoyl-L-leucyl-glycine nitrile

Fasciola hepatica

-

-

709299

N-2-fluorobenzoyl-L-alanine-beta-alanine nitrile

Fasciola hepatica

-

-

709299

N-2-fluorobenzoyl-L-alanine-glycine nitrile

Fasciola hepatica

-

-

709299

N-2-fluorobenzoyl-L-leucine-beta-alanine benzyl ester

Fasciola hepatica

-

-

709299

N-2-fluorobenzoyl-L-leucine-beta-alanine nitrile

Fasciola hepatica

-

-

709299

N-2-fluorobenzoyl-L-leucine-gamma-aminobutyric acid benzyl ester

Fasciola hepatica

-

-

709299

N-2-fluorobenzoyl-L-leucyl-glycine benzyl ester

Fasciola hepatica

-

-

709299

N-2-fluorobenzoyl-L-leucyl-glycine nitrile

Fasciola hepatica

-

-

709299

N-2-trifluoromethylbenzoyl-L-leucyl-glycine nitrile

Fasciola hepatica

-

-

709299

N-3,4,5-trifluorobenzoyl-L-leucyl-glycine nitrile

Fasciola hepatica

-

-

709299

N-3,4-difluorobenzoyl-L-leucyl-glycine nitrile

Fasciola hepatica

-

-

709299

N-3,5-difluorobenzoyl-L-leucyl-glycine nitrile

Fasciola hepatica

-

-

709299

N-3-fluorobenzoyl-L-leucine-beta-alanine benzyl ester

Fasciola hepatica

-

-

709299

N-3-fluorobenzoyl-L-leucine-gamma-aminobutyric acid benzyl ester

Fasciola hepatica

-

-

709299

N-3-fluorobenzoyl-L-leucyl-glycine benzyl ester

Fasciola hepatica

-

-

709299

N-3-fluorobenzoyl-L-leucyl-glycine nitrile

Fasciola hepatica

-

-

709299

N-3-trifluoromethylbenzoyl-L-leucyl-glycine nitrile

Fasciola hepatica

-

-

709299

N-4-fluorobenzoyl-L-leucine-beta-alanine benzyl ester

Fasciola hepatica

-

-

709299

N-4-fluorobenzoyl-L-leucine-beta-alanine nitrile

Fasciola hepatica

-

-

709299

N-4-fluorobenzoyl-L-leucine-gamma-aminobutyric acid benzyl ester

Fasciola hepatica

-

-

709299

N-4-fluorobenzoyl-L-leucyl-glycine benzyl ester

Fasciola hepatica

-

-

709299

N-4-fluorobenzoyl-L-leucyl-glycine nitrile

Fasciola hepatica

-

-

709299

N-4-trifluoromethylbenzoyl-L-leucyl-glycine nitrile

Fasciola hepatica

-

-

709299

N-benzoyl-L-leucyl-glycine

Fasciola hepatica

-

-

709299

N-benzyloxycarbonyl-FY(tert-butyl)-diazomethylketone

Diaprepes abbreviatus

Q0PZI4

40.6% inhibition at 0.05 mM

754348

N-benzyloxycarbonylphenylalanyl-t-butyl-tryrosyl diazomethylketone

Diaprepes abbreviatus

-

40.6% inhibition at 0.05 mM

732290

N-cinnamoyl-L-leucyl-glycine nitrile

Fasciola hepatica

-

-

709299

N-pentafluorobenzoyl-L-alanine-beta-alanine nitrile

Fasciola hepatica

-

-

709299

N-pentafluorobenzoyl-L-alanine-glycine nitrile

Fasciola hepatica

-

-

709299

N-pentafluorobenzoyl-L-leucine-beta-alanine benzyl ester

Fasciola hepatica

-

-

709299

N-pentafluorobenzoyl-L-leucine-gamma-aminobutyric acid benzyl ester

Fasciola hepatica

-

-

709299

N-pentafluorobenzoyl-L-leucyl-glycine benzyl ester

Fasciola hepatica

-

-

709299

Stefin A

Homo sapiens

P07711

-

755132

-

Stefin B

Homo sapiens

P07711

-

755132

-

additional information

5 entries

-

Aprotinin

Diaprepes abbreviatus

-

complete inhibition at 50 nM at a molar ratio of enzyme to inhibitor of 17:1; inhibits enzyme activity almost completely at a molar ratio of enzyme to inhibitor of 17:1

732290

Aprotinin

Diaprepes abbreviatus

Q0PZI4

-

754348

CA074

Diaprepes abbreviatus

-

25.3% inhibition at 0.05 mM

732290

CA074

Diaprepes abbreviatus

Q0PZI4

25.3% inhibition at 0.05 mM

754348

chymostatin

Diaprepes abbreviatus

-

85.6% inhibition at 0.05 mM

732290

chymostatin

Diaprepes abbreviatus

Q0PZI4

85.6% inhibition at 0.05 mM

754348

cystatin

Diaprepes abbreviatus

-

47.5% inhibition at 0.05 mM

732290

-

cystatin

Diaprepes abbreviatus

Q0PZI4

47.5% inhibition at 0.05 mM

754348

-

E-64

Diaprepes abbreviatus

-

i.e. L-trans-epoxysuccinyl-leucyamido(4-guanidino) butane, 26.6% inhibition at 0.05 mM

732290

E-64

Diaprepes abbreviatus

Q0PZI4

26.6% inhibition at 0.05 mM

754348

additional information

Fasciola hepatica

-

cathepsin L2 is completely inactivated by 4 mM tetranitromethane, cathepsin L1 is not inactivated

647701

-

additional information

Fasciola hepatica

H8WG11

the enzyme's fibrinolytic activity is inhibited by plasma. Addition of GSH to plasma cannot counteract the inhibitory effect of plasma components for FhCL1

754672

-

additional information

Fasciola hepatica

-

the enzyme's fibrinolytic activity is inhibited by plasma. Addition of GSH to plasma cannot counteract the inhibitory effect of plasma components for FhCL1

754672

-

additional information

Homo sapiens

P07711

inhibitory interactions of human family 1 and 2 cystatins with cathepsin L1 are predicted and their stability and viability are verified through protein docking and comparative molecular dynamics, overview. The key amino acid residues surfaced via interaction energy, hydrogen bonding and solvent accessible surface area analysis for each cystatin-cathepsin L1 complex influence the mode of binding and thus control the diverse inhibitory affinity of cystatins towards cysteine proteases. Docking outputs of cathepsin L1 complexes with stefin A, stefin B, cystatin C, cystatin D, cystatin F, cystatin M/E, cystatin S, cystatin SA, and cystatin SN

755132

-

additional information

Homo sapiens

-

inhibitory interactions of human family 1 and 2 cystatins with cathepsin L1 are predicted and their stability and viability are verified through protein docking and comparative molecular dynamics, overview. The key amino acid residues surfaced via interaction energy, hydrogen bonding and solvent accessible surface area analysis for each cystatin-cathepsin L1 complex influence the mode of binding and thus control the diverse inhibitory affinity of cystatins towards cysteine proteases. Docking outputs of cathepsin L1 complexes with stefin A, stefin B, cystatin C, cystatin D, cystatin F, cystatin M/E, cystatin S, cystatin SA, and cystatin SN

755132

-