3.4.22.B49: cathepsin L1

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For detailed information about cathepsin L1, go to the full flat file.

Reaction

clear preference for Arg at P1 position (Lys, Glu, Thr, and Met are less efficient). FheCL1 shows distinct preference for hydrophobic amino acids in the P2, Leu is favored. Cathepsin L1 can accommodate Pro in the P2 position, but less efficiently than cathepsin L2. FheCL1 produces clear degradation fragments from collagen =

Synonyms

cat-L1H, cathepsin L1, cathepsin L1 cysteine protease, cathepsin L1 protease, cathepsin L1 proteinase, cathepsin L1g, cathepsin L1H, CatL1, CgCTSL1, CGI_10027418, CL1, CPFhW, CTSL1, cysteine proteinase 3, Da-CTSL1, FgCatL1H, FhCL1, FheCL1, FhpCL1

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.B49 cathepsin L1

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Results	in table
7	Activating Compound
14	AA Sequence
18	Application
1	CAS Registry Number
22	Cloned(Commentary)
1	Crystallization (Commentary)
83	Disease/ Diagnostics
3	Expression
8	General Information
39	IC50 Value
66	Inhibitors
6	Ki Value [mM]
44	KM Value [mM]
6	Localization
16	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
42	Organism
6	pH Optimum
4	pH Range
5	pH Stability
2	pI Value
7	Posttranslational Modification
10	Protein Variants
21	Purification (Commentary)
1	Reaction
1	Reaction Type
40	Reference
2	Renatured (Commentary)
29	Source Tissue
2	Specific Activity [micromol/min/mg]
74	Substrates and Products (Substrate)
14	Subunits
54	Synonyms
3	Temperature Optimum [°C]
1	Temperature Stability [°C]
43	Turnover Number [1/s]

Expression

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Expression on EC 3.4.22.B49 - cathepsin L1

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

the expression level of CL1 mRNA is significantly down-regulated at 12 h and 24 h in digestive gland after Vibrio alginolyticus stimulation

Pinctada fucata

D3XLA0

708536

the expression level of CL1 mRNA is significantly up-regulated at 4 h and 8 h in digestive gland after Vibrio alginolyticus stimulation

Pinctada fucata

D3XLA0

708536

under starvation conditions, cathepsin L1 expression is decreased at 30 days

Paralichthys olivaceus

-

717398