3.4.22.B27: calpain 7
This is an abbreviated version!
For detailed information about calpain 7, go to the full flat file.
Word Map on EC 3.4.22.B27
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3.4.22.B27
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calpains
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endosomal
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escrt
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escrt-iii
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penta-ef-hand
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hek293t
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autolytic
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ist1
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mit-interacting
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flag-tagged
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microtubule-interacting
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pulldown
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multivesicular
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strep-tagged
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epitope-tagged
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chmp1b
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calpain-like
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calcium-activated
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dominant-negative
- 3.4.22.B27
- calpains
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endosomal
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escrt
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escrt-iii
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penta-ef-hand
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hek293t
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autolytic
- ist1
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mit-interacting
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flag-tagged
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microtubule-interacting
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pulldown
-
multivesicular
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strep-tagged
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epitope-tagged
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chmp1b
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calpain-like
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calcium-activated
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dominant-negative
Reaction
broad endopeptidase specificity =
Synonyms
calpain 7/PalBH, calpain-7, capn 7, CAPN7, CL7, PalB homolog, PalBH
ECTree
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Substrates Products
Substrates Products on EC 3.4.22.B27 - calpain 7
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REACTION DIAGRAM
C-terminally truncated ALG-2-interacting protein X + H2O
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limited proteolysis of C-terminally truncated ALG-2-interacting protein X , but not full-length ALIX. Importance of the CHMP4-ALIX interaction for ALIX truncated mutant cleavage, CHMP4 proteins are part of the ESCRT system
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domain 1 of calpastatin-Bro1 domain fuion protein + H2O
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the calpain-7 cleavage site is located between ELLAK (207-211) and KEGIT(212-216) at the C-terminal border of sub-domain B
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calpain 7 plays roles in the endosomal pathway by interacting with a subset of ESCRT-III-related proteins
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additional information
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C-terminal deletion mutants of charged multivesicular body protein 1B enhances autolytic activity of calpain-7 in cells
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additional information
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GST-MIM protein enhances the autolysis of purified Strep-tagged monomeric green fluorescent protein-fused calpain 7. Calpain 7 is activated in the endosomal sorting complex required for transport system
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additional information
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GST-MIM protein enhances the autolysis of purified Strep-tagged monomeric green fluorescent protein-fused calpain 7. Calpain 7 is activated in the endosomal sorting complex required for transport system
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additional information
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the enzyme interacts with a subset of endosomal sorting complex required for transport (ESCRT)-III and ESCRT-III-related proteins, including charged multivesicular body protein 1
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additional information
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calpain-7 performs autolysis, ESCRT proteins enhance the calpain-7 autolysis. Engineered FLAG-tagged casein-Bro1 domain is no substrate
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