3.4.22.B26: calpain 6

This is an abbreviated version!
For detailed information about calpain 6, go to the full flat file.

Reaction

A microtubule-stabilizing protein. The enzyme lacks the active-site catalytic cysteine residue and proteolytic activity has not been detected. =

Synonyms

calpain 6, calpain-6, CAPN6

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.B26 calpain 6

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Results	in table
2	AA Sequence
4	Application
141	Disease/ Diagnostics
4	Expression
9	General Information
2	Inhibitors
6	Organism
1	Reaction
6	Reference
18	Source Tissue
4	Synonyms

Expression

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of the Enzyme Summary Page.

Expression on EC 3.4.22.B26 - calpain 6

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

calpain-6 expression depends on NFkappaB activity and endothelin-1. Calpain-6 expression is increased by doxorubicin

Homo sapiens

-

717676

calpain-6 expression in osteosarcoma cells depends on endothelin-1. Calpain-6 is increased by doxorubicin (10 ng/ml) and expressed at higher levels in doxorubicin-resistant U2OS osteosarcoma-derived cells as compared to responsive cells

Homo sapiens

-

717676

calpain-6 is a target gene downregulated by syndecan-2 in cells and in vivo. Syndecan-2 decreases calpain-6 expression by inhibiting endothelin-1-induced signaling

Homo sapiens

-

717676

calpain-6 mRNA and CAPN6 protein levels are down-regulated by 10% fetal calf serum

Mus musculus

-

717897