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3.4.22.B26: calpain 6

This is an abbreviated version!
For detailed information about calpain 6, go to the full flat file.

Word Map on EC 3.4.22.B26

Reaction

A microtubule-stabilizing protein. The enzyme lacks the active-site catalytic cysteine residue and proteolytic activity has not been detected. =

Synonyms

calpain 6, calpain-6, CAPN6

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B26 calpain 6

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Resultsin table
2AA Sequence
4Application
141Disease/ Diagnostics
4Expression
9General Information
2Inhibitors
6Organism
1Reaction
6Reference
18Source Tissue
4Synonyms

Disease

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Disease on EC 3.4.22.B26 - calpain 6

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Atherosclerosis
Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing.
Bone Resorption
Calpain 6, a target molecule of glucocorticoids, regulates osteoclastic bone resorption via cytoskeletal organization and microtubule acetylation.
calpain 6 deficiency
Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing.
Calpain-6 deficiency promotes skeletal muscle development and regeneration.
Deficiency of calpain-6 inhibits primary ciliogenesis.
Carcinogenesis
Calpain 6 supports tumorigenesis by inhibiting apoptosis and facilitating angiogenesis.
CAPN6 in disease: An emerging therapeutic target (Review).
Decreased calpain 6 expression is associated with tumorigenesis and poor prognosis in HNSCC.
Integrated analysis reveals candidate mRNA and their potential roles in uterine leiomyomas.
Carcinoma
Decreased calpain 6 expression is associated with tumorigenesis and poor prognosis in HNSCC.
Carcinoma, Squamous Cell
Decreased calpain 6 expression is associated with tumorigenesis and poor prognosis in HNSCC.
Carcinosarcoma
Increased expression of calpain 6 in uterine sarcomas and carcinosarcomas: an immunohistochemical analysis.
Diabetic Nephropathies
Cluster analysis and phylogenetic relationship in biomarker identification of type 2 diabetes and nephropathy.
Intellectual Disability
Integrated STS/YAC physical, genetic, and transcript map of human Xq21.3 to q23/q24 (DXS1203-DXS1059).
Leiomyoma
CAPN6 Regulates Uterine Leiomyoma Cell Proliferation and Apoptosis through the Rac1-Dependent Signaling Pathway.
Differential gene expression in uterine leiomyoma.
Leiomyosarcoma
Increased expression of calpain 6 in uterine sarcomas and carcinosarcomas: an immunohistochemical analysis.
Leukemia
Cluster analysis and phylogenetic relationship in biomarker identification of type 2 diabetes and nephropathy.
Liver Neoplasms
miR-449a promotes liver cancer cell apoptosis by downregulation of Calpain 6 and POU2F1.
Muscular Atrophy
Calpain 6 inhibits autophagy in inflammatory environments: A preliminary study on myoblasts and a chronic kidney disease rat model.
Muscular Dystrophies
CAPN6 in disease: An emerging therapeutic target (Review).
Neoplasm Metastasis
Calpain-6 is an endothelin-1 signaling dependent protective factor in chemoresistant osteosarcoma.
Neoplasms
Calpain 6 inhibits autophagy in inflammatory environments: A preliminary study on myoblasts and a chronic kidney disease rat model.
Calpain 6 supports tumorigenesis by inhibiting apoptosis and facilitating angiogenesis.
Calpain-6 controls the fate of sarcoma stem cells by promoting autophagy and preventing senescence.
Calpain-6 is an endothelin-1 signaling dependent protective factor in chemoresistant osteosarcoma.
CAPN6 in disease: An emerging therapeutic target (Review).
Decreased calpain 6 expression is associated with tumorigenesis and poor prognosis in HNSCC.
Increased expression of calpain 6 during the progression of uterine cervical neoplasia: Immunohistochemical analysis.
Increased expression of calpain 6 in uterine sarcomas and carcinosarcomas: an immunohistochemical analysis.
miR-449a promotes liver cancer cell apoptosis by downregulation of Calpain 6 and POU2F1.
The PI3K-Akt pathway regulates calpain 6 expression, proliferation, and apoptosis.
Osteosarcoma
Calpain-6 is an endothelin-1 signaling dependent protective factor in chemoresistant osteosarcoma.
CAPN6 in disease: An emerging therapeutic target (Review).
Prion Diseases
Gene and protein patterns of potential prion-related markers in the central nervous system of clinical and preclinical infected sheep.
Renal Insufficiency, Chronic
Calpain 6 inhibits autophagy in inflammatory environments: A preliminary study on myoblasts and a chronic kidney disease rat model.
Sarcoma
Calpain-6 controls the fate of sarcoma stem cells by promoting autophagy and preventing senescence.
Increased expression of calpain 6 in uterine sarcomas and carcinosarcomas: an immunohistochemical analysis.
Scrapie
Gene and protein patterns of potential prion-related markers in the central nervous system of clinical and preclinical infected sheep.
Squamous Cell Carcinoma of Head and Neck
Decreased calpain 6 expression is associated with tumorigenesis and poor prognosis in HNSCC.
Uterine Cervical Neoplasms
Calpain 6 supports tumorigenesis by inhibiting apoptosis and facilitating angiogenesis.