3.4.22.B26: calpain 6

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For detailed information about calpain 6, go to the full flat file.

Reaction

A microtubule-stabilizing protein. The enzyme lacks the active-site catalytic cysteine residue and proteolytic activity has not been detected. =

Synonyms

calpain 6, calpain-6, CAPN6

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.B26 calpain 6

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Results	in table
2	AA Sequence
4	Application
141	Disease/ Diagnostics
4	Expression
9	General Information
2	Inhibitors
6	Organism
1	Reaction
6	Reference
18	Source Tissue
4	Synonyms

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Application on EC 3.4.22.B26 - calpain 6

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

medicine

4 entries

medicine

Homo sapiens

-

calpain-6 is a therapeutic target in chemoresistant osteosarcoma

717676

medicine

Homo sapiens

-

calpain-6 is a possible therapeutic target in chemoresistant osteosarcoma

717676

medicine

Homo sapiens

Q9Y6Q1

calpain-6 expression is associated with cancer stem cell features. Calpain-6 levels are especially high in tumors that have been successfully propagated in mouse to establish patient-derived xenografts. Calpain-6 levels are increased by hypoxia in vitro and calpain-6 is detected within hypoxic areas in tumors. Calpain-6 expression depends on the stem cell transcription network that involves Oct4, Nanog, and Sox2 and is activated by hypoxia. Calpain-6 expression in sarcomas inversely correlates with senescence markers. Calpain-6 knockdown suppresses hypoxia-dependent prevention of senescence entry and also promotion of autophagic flux

754561

medicine

Mus musculus

O35646

calpain-6 expression is associated with cancer stem cell features. In mouse models of bone sarcoma, calpain-6-expressing cells have unique tumor-initiating and metastatic capacities. Calpain-6 levels are especially high in tumors that have been successfully propagated in mouse to establish patient-derived xenografts. Calpain-6 levels are increased by hypoxia in vitro and calpain-6 is detected within hypoxic areas in tumors. Calpain-6 knockdown blocks tumor development in mouse and induces depletion of the cancer stem cell population. Calpain-6 expression depends on the stem cell transcription network that involves Oct4, Nanog, and Sox2 and is activated by hypoxia. Calpain-6 expression in sarcomas inversely correlates with senescence markers. Calpain-6 knockdown suppresses hypoxia-dependent prevention of senescence entry and also promotion of autophagic flux

754561