3.4.22.B24: calpain 4

This is an abbreviated version!
For detailed information about calpain 4, go to the full flat file.

Reaction

broad endopeptidase specificity =

Synonyms

calcium-activated neutral proteinase, calpain 4, calpain regulatory subunit, calpain small subunit, calpain small subunit 1, CANP, Capn4, Css-1, More

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.B24 calpain 4

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Results	in table
5	AA Sequence
2	Application
1	CAS Registry Number
2	Cloned(Commentary)
5	Crystallization (Commentary)
333	Disease/ Diagnostics
1	Expression
5	General Information
3	Inhibitors
6	Localization
8	Metals/Ions
1	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
28	Organism
1	Reaction
2	Reaction Type
28	Reference
11	Source Tissue
15	Substrates and Products (Substrate)
7	Subunits
16	Synonyms

General Information

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General Information on EC 3.4.22.B24 - calpain 4

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

malfunction

Mus musculus

-

deletion of calpain 4 leads to reduced chondrocyte proliferation and differentiation in embryonic growth plates. Deletion of calpain 4 in cells of the chondrocyte lineage correlated with impaired cell cycle progression at the G1/S transition, reduced cyclin D gene transcription

718110

physiological function

4 entries

physiological function

Mus musculus

-

calpain 4 is a small regulatory calpain subunit required for expression and activity of ubiquitously expressed calpains 1 and 2 in CD4+ T cells. Calpain 4 is not required for T cell development and apoptosis. Calpain 4 is not necessary for LFA-1-mediated adhesion, conjugation or migration in CD4+ T cells

710389

physiological function

Homo sapiens

-

Capn4 as a regulatory subunit is essential for micro- and m-calpain activity, the upregulation of Capn4 mediated by HBx contributes to migration of hepatoma cells

709489

physiological function

Mus musculus

-

calpain 4 is essential for proper chondrocyte functions in embryonic growth plates

718110

physiological function

Mus musculus

-

calpain 4 is essential for the secretion and tyrosine phosphorylation of galectin-3

717198