3.4.22.B19: YopJ protease
This is an abbreviated version!
For detailed information about YopJ protease, go to the full flat file.
Word Map on EC 3.4.22.B19
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3.4.22.B19
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enterocolitica
-
pestis
-
pseudotuberculosis
-
plague
-
yersinia-infected
-
listeriolysin
-
iii-dependent
- 3.4.22.B19
- enterocolitica
- pestis
- pseudotuberculosis
- plague
-
yersinia-infected
-
listeriolysin
-
iii-dependent
Reaction
cleaves reversible post-translational modification in form of ubiquitin or a ubiquitin-like protein. It inhibits the host immune response and induces apoptosis by blocking multiple signaling pathways, including the MAPK and NfkappaB pathways in the infected cell =
Synonyms
C55.001, outer protein T, virulence factor YopJ, Yersinia outer protein, Yersinia outer protein J, Yersinia outer protein P, Yersinia outer protein T, YopJ, YopJKIM, YopP, YopT
ECTree
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Reference on EC 3.4.22.B19 - YopJ protease
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Galyov, E.E.; Haakansson, S.; Wolf-Watz, H.
Characterization of the operon encoding the YpkA Ser/Thr protein kinase and the YopJ protein of Yersinia pseudotuberculosis
J. Bacteriol.
176
4532-4548
1994
Yersinia pseudotuberculosis (P31498)
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Krause, M.; Harwood, J.; Fierer, J.; Guiney, D.
Genetic analysis of homology between the virulence plasmids of Salmonella dublin and Yersinia pseudotuberculosis
Infect. Immun.
59
1860-1863
1991
Yersinia pseudotuberculosis (P31498)
Orth, K.; Xu, Z.; Mudgett, M.B.; Bao, Z.Q.; Palmer, L.E.; Bliska, J.B.; Mangel, W.F.; Staskawicz, B.; Dixon, J.E.
Disruption of signaling by Yersinia effector YopJ, a ubiquitin-like protein protease
Science
290
1594-1597
2000
Yersinia sp.
Orth, K.
Function of the Yersinia effector YopJ
Curr. Opin. Microbiol.
5
38-43
2002
Yersinia sp.
Monnazzi, L.G.; Carlos, I.Z.; de Medeiros, B.M.
Influence of Yersinia pseudotuberculosis outer proteins (Yops) on interleukin-12, tumor necrosis factor alpha and nitric oxide production by peritoneal macrophages
Immunol. Lett.
94
91-98
2004
Yersinia pseudotuberculosis
Zauberman, A.; Cohen, S.; Mamroud, E.; Flashner, Y.; Tidhar, A.; Ber, R.; Elhanany, E.; Shafferman, A.; Velan, B.
Interaction of Yersinia pestis with macrophages: limitations in YopJ-dependent apoptosis
Infect. Immun.
74
3239-3250
2006
Yersinia pestis
Bliska, J.B.
Yersinia inhibits host signaling by acetylating MAPK kinases
ACS Chem. Biol.
1
349-351
2006
Yersinia pestis, Yersinia pseudotuberculosis, Yersinia enterocolitica
Sweet, C.R.; Conlon, J.; Golenbock, D.T.; Goguen, J.; Silverman, N.
YopJ targets TRAF proteins to inhibit TLR-mediated NF-kappaB, MAPK and IRF3 signal transduction
Cell. Microbiol.
9
2700-2715
2007
Yersinia pestis
Zhou, H.; Monack, D.M.; Kayagaki, N.; Wertz, I.; Yin, J.; Wolf, B.; Dixit, V.M.
Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-kappaB activation
J. Exp. Med.
202
1327-1332
2005
Yersinia pseudotuberculosis
Sun, J.
Pathogenic bacterial proteins and their anti-inflammatory effects in the eukaryotic host
Antiinflamm. Antiallergy Agents Med. Chem.
8
214-227
2009
Yersinia sp.
Dach, K.; Zovko, J.; Hogardt, M.; Koch, I.; van Erp, K.; Heesemann, J.; Hoffmann, R.
Bacterial toxins induce sustained mRNA expression of the silencing transcription factor klf2 via inactivation of RhoA and Rhophilin 1
Infect. Immun.
77
5583-5592
2009
Yersinia enterocolitica
Zhang, Y.; Bliska, J.B.
YopJ-promoted cytotoxicity and systemic colonization are associated with high levels of murine interleukin-18, gamma interferon, and neutrophils in a live vaccine model of Yersinia pseudotuberculosis infection
Infect. Immun.
78
2329-2341
2010
Yersinia pseudotuberculosis
Wiley, D.J.; Shrestha, N.; Yang, J.; Atis, N.; Dayton, K.; Schesser, K.
The activities of the Yersinia protein kinase A (YpkA) and outer protein J (YopJ) virulence factors converge on an eIF2alpha kinase
J. Biol. Chem.
284
24744-24753
2009
Yersinia pestis
Zauberman, A.; Tidhar, A.; Levy, Y.; Bar-Haim, E.; Halperin, G.; Flashner, Y.; Cohen, S.; Shafferman, A.; Mamroud, E.
Yersinia pestis endowed with increased cytotoxicity is avirulent in a bubonic plague model and induces rapid protection against pneumonic plague
PLoS ONE
4
e5938
2009
Yersinia pestis, Yersinia pestis Kimberley53
Spinner, J.L.; Seo, K.S.; OLoughlin, J.L.; Cundiff, J.A.; Minnich, S.A.; Bohach, G.A.; Kobayashi, S.D.
Neutrophils are resistant to Yersinia YopJ/P-induced apoptosis and are protected from ROS-mediated cell death by the type III secretion system
PLoS ONE
5
e9279
2010
Yersinia pestis, Yersinia enterocolitica, Yersinia enterocolitica 8081v
Schmidt, G.
Yersinia enterocolitica outer protein T (YopT)
Eur. J. Cell Biol.
90
955-958
2011
Yersinia enterocolitica
Tansini, A.; Da Silva, F.; Dos Santos Jr., R.; Placeres, M.; De Medeiros, B.; Carlos, I.
Yop effector proteins from Yersinia pseudotuberculosis impair dendritic cell activation
Adv. Exp. Med. Biol.
954
203-208
2012
Yersinia pseudotuberculosis
Zheng, Y.; Lilo, S.; Mena, P.; Bliska, J.B.
YopJ-induced caspase-1 activation in Yersinia-infected macrophages: independent of apoptosis, linked to necrosis, dispensable for innate host defense
PLoS ONE
7
e36019
2012
Yersinia pestis, Yersinia pestis KIM5
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