3.4.22.B19: YopJ protease

This is an abbreviated version, for detailed information about YopJ protease, go to the full flat file.

Reaction

cleaves reversible post-translational modification in form of ubiquitin or a ubiquitin-like protein. It inhibits the host immune response and induces apoptosis by blocking multiple signaling pathways, including the MAPK and NfkappaB pathways in the infected cell =

Synonyms

C55.001, outer protein T, virulence factor YopJ, Yersinia outer protein, Yersinia outer protein J, Yersinia outer protein P, Yersinia outer protein T, YopJ, YopJKIM, YopP, YopT

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B19 YopJ protease