3.4.22.B14: papain-like proteinase 1

This is an abbreviated version, for detailed information about papain-like proteinase 1, go to the full flat file.

Reaction

papain-like proteinase 1 is responsible for cleavages located at the N-terminus of the replicase polyprotein =

Synonyms

C16.001, first papain-like cysteine proteinase, mouse hepatitis virus papain-like proteinase 1, PL1-PRO, PL1pro, PLP-1, PLP1, PLP1 proteinase, PLpro, replicase polyprotein 1a

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B14 papain-like proteinase 1

Inhibitors

Inhibitors on EC 3.4.22.B14 - papain-like proteinase 1

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2,6-dimethyl-N-[(R)-1-(2-naphthyl)ethyl]benzamide
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2,N-dimethyl-N-[(R)-1-(2-naphthyl)ethyl]benzamide
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2-methoxy-N-[(R)-1-(2-naphthyl)ethyl]benzamide
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2-methoxymethyl-5-nitrobenzoic acid methyl ester
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2-methyl-N-[(R)-1-(1-naphthyl)ethyl]benzamide
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2-methyl-N-[1-(naphthalen-2-yl)ethyl]benzamide
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3-methoxy-N-[(R)-1-(2-naphthyl)ethyl]benzamide
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3-methyl-N-[(R)-1-(2-naphthyl)ethyl]benzamide
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4-amino-N-[(R)-1-(1-naphthyl)ethyl]benzamide
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4-amino-N-[(R)-1-(2-naphthyl)ethyl]benzamide
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4-methoxy-N-[(R)-1-(2-naphthyl)ethyl]benzamide
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4-methyl-N-[(R)-1-(2-naphthyl)ethyl]benzamide
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5-amino-2-methoxymethyl-N-[1-methyl-1-(1-naphthyl)ethyl]benzamide
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5-amino-2-methyl-N-[(R)-1-(1-naphthyl)ethyl]benzamide
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5-amino-2-methyl-N-[1-methyl-1-(1-naphthyl)ethyl]benzamide
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5-cyano-2-methyl-N-[1-methyl-1-(1-naphthyl)ethyl]benzamide
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5-iodo-2-methyl-N-[1-methyl-1-(1-naphthyl)ethyl]benzamide
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5-methylamino-2-methyl-N-[(R)-1-(1-naphthyl)ethyl]benzamide
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5-N-acetylamino-2-methyl-N-[(R)-1-(1-naphthyl)ethyl]benzamide
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5-N-tert-butoxycarbonylmethylamino-2-methyl-N'-[(R)-1-(1-naphthyl)ethyl]benzamide
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E-64d
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membrane-permeable do the irreversible cysteine proteinase inhibitor E-64 blocks cleavage of p65 in vivo
leupeptin
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blocks the ability of PLP1 to cleave p28 in vitro but not in vivo due to permeability and toxicity issues
N-methyl-5-methylamino-2-methyl-N'-[(R)-1-(1-naphthyl)ethyl]benzamide
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ZnCl2
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blocks the ability of PLP1 to cleave p28 in vitro but not in vivo due to permeability and toxicity issues
additional information
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not inhibited by 2-hydroxy-N-[(R)-1-(2-naphthyl)ethyl]benzamide, 4-N'-tert-butoxycarbonylamino-N-[(R)-1-(2-naphthyl)ethyl]-benzamide, 2-methyl-N-[1-(2-naphthyl)propyl]benzamide, and 2-methyl-N-[1-(2-naphthyl)benzyl]benzamide
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