3.4.22.B14: papain-like proteinase 1

This is an abbreviated version!
For detailed information about papain-like proteinase 1, go to the full flat file.

Reaction

papain-like proteinase 1 is responsible for cleavages located at the N-terminus of the replicase polyprotein =

Synonyms

C16.001, first papain-like cysteine proteinase, mouse hepatitis virus papain-like proteinase 1, PL1, PL1-PRO, PL1pro, PLP-1, PLP1, PLP1 proteinase, PLpro, replicase polyprotein 1a

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.B14 papain-like proteinase 1

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Results	in table
9	AA Sequence
7	Cloned(Commentary)
3	Crystallization (Commentary)
6	General Information
21	IC50 Value
25	Inhibitors
2	kcat/KM [mM/s]
1	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
51	Organism
3	Protein Variants
4	Purification (Commentary)
1	Reaction
1	Reaction Type
32	Reference
53	Substrates and Products (Substrate)
30	Synonyms
1	Temperature Optimum [°C]

IC50 Value

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IC50 Value on EC 3.4.22.B14 - papain-like proteinase 1

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0121

2,6-dimethyl-N-[(R)-1-(2-naphthyl)ethyl]benzamide

Severe acute respiratory syndrome-related coronavirus

-

in 50 mM HEPES, pH 7.5

709449

0.0226

2,N-dimethyl-N-[(R)-1-(2-naphthyl)ethyl]benzamide

Severe acute respiratory syndrome-related coronavirus

-

in 50 mM HEPES, pH 7.5

709449

0.09

2-methoxy-N-[(R)-1-(2-naphthyl)ethyl]benzamide

Severe acute respiratory syndrome-related coronavirus

-

in 50 mM HEPES, pH 7.5

709449

0.0014

2-methoxymethyl-5-nitrobenzoic acid methyl ester

Severe acute respiratory syndrome-related coronavirus

-

in 50 mM HEPES, pH 7.5

709449

0.0023

2-methyl-N-[(R)-1-(1-naphthyl)ethyl]benzamide

Severe acute respiratory syndrome-related coronavirus

-

in 50 mM HEPES, pH 7.5

709449

0.0087

2-methyl-N-[1-(naphthalen-2-yl)ethyl]benzamide

Severe acute respiratory syndrome-related coronavirus

-

in 50 mM HEPES, pH 7.5

709449

0.0135

3-methoxy-N-[(R)-1-(2-naphthyl)ethyl]benzamide

Severe acute respiratory syndrome-related coronavirus

-

in 50 mM HEPES, pH 7.5

709449

0.0148

3-methyl-N-[(R)-1-(2-naphthyl)ethyl]benzamide

Severe acute respiratory syndrome-related coronavirus

-

in 50 mM HEPES, pH 7.5

709449

0.0248

4-amino-N-[(R)-1-(1-naphthyl)ethyl]benzamide

Severe acute respiratory syndrome-related coronavirus

-

in 50 mM HEPES, pH 7.5

709449

0.0461

4-amino-N-[(R)-1-(2-naphthyl)ethyl]benzamide

Severe acute respiratory syndrome-related coronavirus

-

in 50 mM HEPES, pH 7.5

709449

0.149

4-methoxy-N-[(R)-1-(2-naphthyl)ethyl]benzamide

Severe acute respiratory syndrome-related coronavirus

-

in 50 mM HEPES, pH 7.5

709449

0.0291

4-methyl-N-[(R)-1-(2-naphthyl)ethyl]benzamide

Severe acute respiratory syndrome-related coronavirus

-

in 50 mM HEPES, pH 7.5

709449

0.0052

5-amino-2-methoxymethyl-N-[1-methyl-1-(1-naphthyl)ethyl]benzamide

Severe acute respiratory syndrome-related coronavirus

-

in 50 mM HEPES, pH 7.5

709449

0.00056

5-amino-2-methyl-N-[(R)-1-(1-naphthyl)ethyl]benzamide

Severe acute respiratory syndrome-related coronavirus

-

in 50 mM HEPES, pH 7.5

709449

0.00056

5-amino-2-methyl-N-[1-methyl-1-(1-naphthyl)ethyl]benzamide

Severe acute respiratory syndrome-related coronavirus

-

in 50 mM HEPES, pH 7.5

709449

0.0111

5-cyano-2-methyl-N-[1-methyl-1-(1-naphthyl)ethyl]benzamide

Severe acute respiratory syndrome-related coronavirus

-

in 50 mM HEPES, pH 7.5

709449

0.0027

5-iodo-2-methyl-N-[1-methyl-1-(1-naphthyl)ethyl]benzamide

Severe acute respiratory syndrome-related coronavirus

-

in 50 mM HEPES, pH 7.5

709449

0.00046

5-methylamino-2-methyl-N-[(R)-1-(1-naphthyl)ethyl]benzamide

Severe acute respiratory syndrome-related coronavirus

-

in 50 mM HEPES, pH 7.5

709449

0.00264

5-N-acetylamino-2-methyl-N-[(R)-1-(1-naphthyl)ethyl]benzamide

Severe acute respiratory syndrome-related coronavirus

-

in 50 mM HEPES, pH 7.5

709449

0.0048

5-N-tert-butoxycarbonylmethylamino-2-methyl-N'-[(R)-1-(1-naphthyl)ethyl]benzamide

Severe acute respiratory syndrome-related coronavirus

-

in 50 mM HEPES, pH 7.5

709449

0.0013

N-methyl-5-methylamino-2-methyl-N'-[(R)-1-(1-naphthyl)ethyl]benzamide

Severe acute respiratory syndrome-related coronavirus

-

in 50 mM HEPES, pH 7.5

709449