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3.4.22.8: clostripain

This is an abbreviated version!
For detailed information about clostripain, go to the full flat file.

Reaction

Preferential cleavage: Arg-/-, including Arg-/-Pro, but not Lys- =

Synonyms

alpha-clostridipain, alpha-clostripain, CLO, clostridiopeptidase, clostridiopeptidase B, Clostridium histolyticum proteinase B, clostripain-like protease, EC 3.4.4.20, proteinase, Clostridium histolyticum, B

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.8 clostripain

Inhibitors

Inhibitors on EC 3.4.22.8 - clostripain

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5,5'-dithiobis(2-nitrobenzoate)
-
-
ADP
-
proteolysis of succinyl-CoA synthetase
antipain
-
potent clostridiopeptidase B-induced kinin release in dog plasma
ATP
-
proteolysis of succinyl-CoA synthetase
benzamidine
benzylamidinyl-diazo dichlorotriazine
-
effective protection by N-benzoyl-L-Arg ethyl ester
benzyloxycarbonyl-Phe-Lys-CH2S(CH3)2
-
irreversible
Borate
-
partial inhibition
Butylamine
-
-
butylguanidine
citrate
-
partial inhibition
diallyl-2,4,4,9-tetramethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
-
-
diallyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
-
-
diallyl-7,8-dichloro-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
-
-
diallyl-7-benzoyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
-
-
dibutyl-2,4,4,9-tetramethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
-
-
dibutyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
-
-
dibutyl-7,8-dichloro-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
-
-
dibutyl-7-benzoyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]diazepin-2-ylphosphonate
-
-
diethyl-2,4,4,9-tetramethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
-
-
diethyl-2,4,4-trimethyl-8-nitro-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]diazepin-2-ylphosphonate
-
-
diethyl-7,8-dichloro-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
-
-
diethyl-7-benzoyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]diazepin-2-ylphosphonate
-
-
diethyldicarbonate
-
-
diisopropylfluorophosphate
-
-
dimethyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo-[b]-[1,4]diazepin-2-ylphosphonate
-
-
dimethyl-2,4,4-trimethyl-8-nitro-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]diazepin-2-ylphosphonate
-
-
dimethyl-7,8-dichloro-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
-
-
dimethyl-7-benzoyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
-
-
E-64
-
0.035 mM, 68% inhibition
ethylamine
-
-
Ethylguanidine
-
-
histatin 5
-
23.6 nM, 50% inhibition, competitive. The salivary protein could be used for the prevention or treatment of topical infactions such as those caused by Clostridium histolyticum
-
iodoacetamide
-
-
iodoacetate
-
-
iodoacetic acid
-
0.035 mM, 13% inhibition
L-1-chloro-3-[4-tosylamido]-7-amino-2-heptanone
-
complete inhibition
L-3-carboxy-2,3-trans-epoxypropionyl-leucylamido-(4-guanidino)butane
-
i.e. compounds E-64
leupeptin
macroglobulin
-
alpha2-macroglobulin from human plasma, inhibits both the amidase and protease activity. Macroglobulin from rat and dog plasma
-
methylamine
-
-
methylguanidine
-
-
N-alpha-p-nitrobenzyloxycarbonyl-Arg chloromethyl ketone
-
irreversible
N-Alpha-p-tosyl-L-homoarginine methyl ester
-
-
N-alpha-p-tosyl-L-Lys chloromethyl ketone
N-Alpha-p-tosyl-L-norarginine methyl ester
-
-
N-tosyl-Lys-chloromethylketone
-
0.035 mM, complete inhibition
Nalpha-tosyl-L-lysine chloromethylketone
-
complete inhibition at 0.01 mg/ml
ovoinhibitor
-
0.05 mM, 55% reduced amidase activity
-
phenylmethylsulfonyl fluoride
-
complete inhibition
Polyarginine
-
hydrolysis of benzoyl-Arg ethyl ester
polylysine
-
hydrolysis of benzoyl-Arg ethyl ester
Propylamine
-
-
propylguanidine
-
-
RCM RNase
-
hydrolysis of benzoyl-Arg ethyl ester
-
tosyl-Lys-chloromethane
-
-
Tris
-
partial inhibition
Trypsin inhibitor
-
Veronal
-
partial inhibition
additional information
-
no inhibition by 0.035 PMSF
-