3.4.22.8: clostripain

This is an abbreviated version!
For detailed information about clostripain, go to the full flat file.

Reaction

Preferential cleavage: Arg-/-, including Arg-/-Pro, but not Lys- =

Synonyms

alpha-clostridipain, alpha-clostripain, CLO, clostridiopeptidase, clostridiopeptidase B, Clostridium histolyticum proteinase B, clostripain-like protease, EC 3.4.4.20, proteinase, Clostridium histolyticum, B

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.22 Cysteine endopeptidases

3.4.22.8 clostripain

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Results	in table
187	AA Sequence
7	Application
1	CAS Registry Number
8	Cloned(Commentary)
4	General Information
1	General Stability
16	IC50 Value
85	Inhibitors
4	kcat/KM [mM/s]
2	Ki Value [mM]
22	KM Value [mM]
1	Localization
3	Metals/Ions
16	Molecular Weight [Da]
42	Organism
9	pH Optimum
3	pH Range
1	Posttranslational Modification
2	Protein Variants
11	Purification (Commentary)
1	Reaction
2	Reaction Type
42	Reference
12	Specific Activity [micromol/min/mg]
84	Substrates and Products (Substrate)
12	Subunits
12	Synonyms
1	Temperature Stability [°C]
16	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.4.22.8 - clostripain

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0.15

diallyl-2,4,4,9-tetramethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate

Hathewaya histolytica

in 100 mM Tris-HCl buffer, pH 7.4, at 37°C

718180

0.032

diallyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate

Hathewaya histolytica

in 100 mM Tris-HCl buffer, pH 7.4, at 37°C

718180

0.09

diallyl-7,8-dichloro-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate

Hathewaya histolytica

in 100 mM Tris-HCl buffer, pH 7.4, at 37°C

718180

0.036

diallyl-7-benzoyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate

Hathewaya histolytica

in 100 mM Tris-HCl buffer, pH 7.4, at 37°C

718180

0.175

dibutyl-2,4,4,9-tetramethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate

Hathewaya histolytica

in 100 mM Tris-HCl buffer, pH 7.4, at 37°C

718180

0.3

dibutyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate

Hathewaya histolytica

IC50 above 0.3 mM, in 100 mM Tris-HCl buffer, pH 7.4, at 37°C

718180

0.14

dibutyl-7,8-dichloro-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate

Hathewaya histolytica

in 100 mM Tris-HCl buffer, pH 7.4, at 37°C

718180

0.3

dibutyl-7-benzoyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]diazepin-2-ylphosphonate

Hathewaya histolytica

IC50 above 0.3 mM, in 100 mM Tris-HCl buffer, pH 7.4, at 37°C

718180

0.08

diethyl-2,4,4,9-tetramethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate

Hathewaya histolytica

in 100 mM Tris-HCl buffer, pH 7.4, at 37°C

718180

0.49

diethyl-2,4,4-trimethyl-8-nitro-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]diazepin-2-ylphosphonate

Hathewaya histolytica

in 100 mM Tris-HCl buffer, pH 7.4, at 37°C

718180

0.22

diethyl-7,8-dichloro-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate

Hathewaya histolytica

in 100 mM Tris-HCl buffer, pH 7.4, at 37°C

718180

0.3

diethyl-7-benzoyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]diazepin-2-ylphosphonate

Hathewaya histolytica

IC50 above 0.3 mM, in 100 mM Tris-HCl buffer, pH 7.4, at 37°C

718180

0.278

dimethyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo-[b]-[1,4]diazepin-2-ylphosphonate

Hathewaya histolytica

in 100 mM Tris-HCl buffer, pH 7.4, at 37°C

718180

0.3

dimethyl-2,4,4-trimethyl-8-nitro-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]diazepin-2-ylphosphonate

Hathewaya histolytica

IC50 above 0.3 mM, in 100 mM Tris-HCl buffer, pH 7.4, at 37°C

718180

0.78

dimethyl-7,8-dichloro-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate

Hathewaya histolytica

in 100 mM Tris-HCl buffer, pH 7.4, at 37°C

718180

0.07

dimethyl-7-benzoyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate

Hathewaya histolytica

in 100 mM Tris-HCl buffer, pH 7.4, at 37°C

718180