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3.4.22.71: sortase B

This is an abbreviated version!
For detailed information about sortase B, go to the full flat file.

Word Map on EC 3.4.22.71

Reaction

The enzyme catalyses a cell wall sorting reaction in which a surface protein with a sorting signal containing a NPXTN motif is cleaved. The resulting threonine carboxyl end of the protein is covalently attached to a pentaglycine cross-bridge of peptidoglycan. =

Synonyms

CD630_27180, class B sortase, CPE0513, sortase B, Spy0129, SrtB, StrB

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.71 sortase B

Substrates Products

Substrates Products on EC 3.4.22.71 - sortase B

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2 amylase-binding adhesin AbpA
(amylase-binding adhesin AbpA)2 + H2O
show the reaction diagram
AbpA-LPKTSAVKLE-green fluorescent protein + H2O
AbpA-LPKT + SAVKLE-green fluorescent protein
show the reaction diagram
Abz-KDFEVPTGVAM-Dap(Dnp)-NH2 + H2O
?
show the reaction diagram
Dabcyl-QANPQTNEE-Edans + H2O
Dabcyl-QANPQT + NEE-Edans
show the reaction diagram
DNPNTGDE + H2O
?
show the reaction diagram
-
-
-
-
?
IsdC + H2O
?
show the reaction diagram
Lmo2185 + H2O
?
show the reaction diagram
-
-
-
-
?
Lmo2186 + H2O
?
show the reaction diagram
-
NPKSS is a sorting motif of Lmo2186. Recognition of NPKSS by SrtB, even when placed in the context of the heterologous sorting signal of Lmo2185. Proline at position 2, and not lysine at position 3, is essential for the recognition of NPKSS by SrtB
-
-
?
PPKTG + H2O
?
show the reaction diagram
SvpA + H2O
?
show the reaction diagram
-
anchoring of SvpA to the bacterial cell wall is specifically mediated by SrzB
-
-
?
additional information
?
-