3.4.22.71: sortase B
This is an abbreviated version!
For detailed information about sortase B, go to the full flat file.
Word Map on EC 3.4.22.71
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3.4.22.71
-
aureus
-
peptidoglycan
-
anthracis
-
envelope
-
transpeptidases
-
cross-bridges
-
isdc
-
pentaglycine
-
pilin
-
transpeptidation
-
analysis
-
medicine
- 3.4.22.71
- aureus
- peptidoglycan
- anthracis
- envelope
- transpeptidases
-
cross-bridges
- isdc
- pentaglycine
- pilin
-
transpeptidation
- analysis
- medicine
Reaction
The enzyme catalyses a cell wall sorting reaction in which a surface protein with a sorting signal containing a NPXTN motif is cleaved. The resulting threonine carboxyl end of the protein is covalently attached to a pentaglycine cross-bridge of peptidoglycan. =
Synonyms
CD630_27180, class B sortase, CPE0513, sortase B, Spy0129, SrtB, StrB
ECTree
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Reference on EC 3.4.22.71 - sortase B
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Jonsson, I.M.; Mazmanian, S.K.; Schneewind, O.; Bremell, T.; Tarkowski, A.
The role of Staphylococcus aureus sortase A and sortase B in murine arthritis
Microbes Infect.
5
775-780
2003
Staphylococcus aureus
Zong, Y.; Mazmanian, S.K.; Schneewind, O.; Narayana, S.V.L.
The structure of sortase B, a cysteine transpeptidase that tethers surface protein to the Staphylococcus aureus cell wall
Structure
12
105-112
2004
Staphylococcus aureus
Bierne, H.; Garandeau, C.; Pucciarelli, M.G.; Sabet, C.; Newton, S.; Garcia-del Portillo, F.; Cossart, P.; Charbit, A.
Sortase B, a new class of sortase in Listeria monocytogenes
J. Bacteriol.
186
1972-1982
2004
Listeria monocytogenes
Oh, K.B.; Oh, M.N.; Kim, J.G.; Shin, D.S.; Shin, J.
Inhibition of sortase-mediated Staphylococcus aureus adhesion to fibronectin via fibronectin-binding protein by sortase inhibitors
Appl. Microbiol. Biotechnol.
70
102-106
2006
Staphylococcus aureus
Kang, S.S.; Kim, J.G.; Lee, T.H.; Oh, K.B.
Flavonols inhibit sortases and sortase-mediated Staphylococcus aureus clumping to fibrinogen
Biol. Pharm. Bull.
29
1751-1755
2006
Staphylococcus aureus
Zink, S.D.; Burns, D.L.
Importance of srtA and srtB for growth of Bacillus anthracis in macrophages
Infect. Immun.
73
5222-5228
2005
Bacillus anthracis
Marraffini, L.A.; Schneewind, O.
Anchor structure of staphylococcal surface proteins. V. Anchor structure of the sortase B substrate IsdC
J. Biol. Chem.
280
16263-16271
2005
Staphylococcus aureus
Newton, S.M.; Klebba, P.E.; Raynaud, C.; Shao, Y.; Jiang, X.; Dubail, I.; Archer, C.; Frehel, C.; Charbit, A.
The svpA-srtB locus of Listeria monocytogenes: fur-mediated iron regulation and effect on virulence
Mol. Microbiol.
55
927-940
2005
Listeria monocytogenes
Pucciarelli, M.G.; Calvo, E.; Sabet, C.; Bierne, H.; Cossart, P.; Garcia-del Portillo, F.
Identification of substrates of the Listeria monocytogenes sortases A and B by a non-gel proteomic analysis
Proteomics
5
4808-4817
2005
Listeria monocytogenes
Zhang, R.; Wu, R.; Joachimiak, G.; Mazmanian, S.K.; Missiakas, D.M.; Gornicki, P.; Schneewind, O.; Joachimiak, A.
Structures of sortase B from Staphylococcus aureus and Bacillus anthracis reveal catalytic amino acid triad in the active site
Structure
12
1147-1156
2004
Bacillus anthracis, Staphylococcus aureus
Maresso, A.W.; Chapa, T.J.; Schneewind, O.
Surface protein IsdC and sortase B are required for heme-iron scavenging of Bacillus anthracis
J. Bacteriol.
188
8145-8152
2006
Bacillus anthracis
Maresso, A.W.; Wu, R.; Kern, J.W.; Zhang, R.; Janik, D.; Missiakas, D.M.; Duban, M.; Joachimiak, A.; Schneewind, O.
Activation of inhibitors by sortase triggers irreversible modification of the active site
J. Biol. Chem.
282
23129-23139
2007
Bacillus anthracis
Bentley, M.L.; Gaweska, H.; Kielec, J.M.; McCafferty, D.G.
Engineering the substrate specificity of Staphylococcus aureus sortase A. The beta6/beta7 loop from SrtB confers NPQTN recognition to SrtA
J. Biol. Chem.
282
6571-6581
2007
Staphylococcus aureus
Mariscotti, J.F.; Garcia-del Portillo, F.; Pucciarelli, M.G.
The Listeria monocytogenes sortase-B recognizes varied amino acids at position 2 of the sorting motif
J. Biol. Chem.
284
6140-6146
2009
Listeria monocytogenes
Oh, K.B.; Nam, K.W.; Ahn, H.; Shin, J.; Kim, S.; Mar, W.
Therapeutic effect of (Z)-3-(2,5-dimethoxyphenyl)-2-(4-methoxyphenyl) acrylonitrile (DMMA) against Staphylococcus aureus infection in a murine model
Biochem. Biophys. Res. Commun.
396
440-444
2010
Staphylococcus aureus, Staphylococcus aureus Newman
Spirig, T.; Weiner, E.; Clubb, R.
Sortase enzymes in Gram-positive bacteria
Mol. Microbiol.
82
1044-1059
2011
Staphylococcus aureus (A0A0H3JPP1)
Kang, H.J.; Coulibaly, F.; Proft, T.; Baker, E.N.
Crystal structure of Spy0129, a Streptococcus pyogenes class B sortase involved in pilus assembly
PLoS ONE
6
e15969
2011
Streptococcus pyogenes, Streptococcus pyogenes M1 SF370
Jacobitz, A.W.; Wereszczynski, J.; Yi, S.W.; Amer, B.R.; Huang, G.L.; Nguyen, A.V.; Sawaya, M.R.; Jung, M.E.; McCammon, J.A.; Clubb, R.T.
Structural and computational studies of the Staphylococcus aureus sortase B-substrate complex reveal a substrate-stabilized oxyanion hole
J. Biol. Chem.
289
8891-8902
2014
Staphylococcus aureus (A0A0H2XI76), Staphylococcus aureus
Wang, G.; Gao, Y.; Wang, H.; Wang, J.; Niu, X.
Phloretin reduces cell injury and inflammation mediated by Staphylococcus aureus via targeting sortase B and the molecular mechanism
Appl. Microbiol. Biotechnol.
102
10665-10674
2018
Staphylococcus aureus
Tamai, E.; Sekiya, H.; Maki, J.; Nariya, H.; Yoshida, H.; Kamitori, S.
X-ray structure of Clostridium perfringens sortase B cysteine transpeptidase
Biochem. Biophys. Res. Commun.
493
1267-1272
2017
Clostridium perfringens (Q8XN25), Clostridium perfringens, Clostridium perfringens 13 (Q8XN25)
Puorger, C.; Di Girolamo, S.; Lipps, G.
Elucidation of the recognition sequence of sortase B from Bacillus anthracis by using a newly developed liquid chromatography-mass spectrometry-based method
Biochemistry
56
2641-2650
2017
Bacillus anthracis
Yin, J.; Fei, C.; Lo, Y.; Hsiao, Y.; Chang, J.; Nix, J.; Chang, Y.; Yang, L.; Huang, I.; Wang, S.
Structural insights into substrate recognition by Clostridium difficile sortase
Front. Cell. Infect. Microbiol.
6
00160
2016
Clostridioides difficile (Q183F3), Clostridioides difficile, Clostridioides difficile 630 (Q183F3)
Wang, G.; Wang, X.; Sun, L.; Gao, Y.; Niu, X.; Wang, H.
Novel Inhibitor discovery of Staphylococcus aureus sortase B and the mechanism confirmation via molecular modeling
Molecules
23
977
2018
Staphylococcus aureus, Staphylococcus aureus ATCC 29213
Liang, X.; Liu, B.; Zhu, F.; Scannapieco, F.; Haase, E.; Matthews, S.; Wu, H.
A distinct sortase SrtB anchors and processes a streptococcal adhesin AbpA with a novel structural property
Sci. Rep.
6
30966
2016
Streptococcus parasanguinis (I1ZJ31), Streptococcus parasanguinis FW213 (I1ZJ31)
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