3.4.22.70: sortase A
This is an abbreviated version!
For detailed information about sortase A, go to the full flat file.
Word Map on EC 3.4.22.70
-
3.4.22.70
-
aureus
-
staphylococcus
-
lpxtg
-
streptococcus
-
peptidoglycan
-
transpeptidation
-
sortase-mediated
-
a-mediated
-
adhesins
-
bioconjugation
-
antivirulence
-
mutans
-
anti-infective
-
pilins
-
transpeptidases
-
oligoglycine
-
cross-bridges
-
pentaglycine
-
wall-anchored
-
molecular biology
-
azide-alkyne
-
analysis
-
biotechnology
-
drug development
-
synthesis
-
medicine
- 3.4.22.70
- aureus
- staphylococcus
-
lpxtg
- streptococcus
- peptidoglycan
-
transpeptidation
-
sortase-mediated
-
a-mediated
- adhesins
-
bioconjugation
-
antivirulence
- mutans
-
anti-infective
- pilins
- transpeptidases
-
oligoglycine
-
cross-bridges
- pentaglycine
-
wall-anchored
- molecular biology
-
azide-alkyne
- analysis
- biotechnology
- drug development
- synthesis
- medicine
Reaction
The enzyme catalyses a cell wall sorting reaction in which a surface protein with a sorting signal containing a LPXTG motif is cleaved between the Thr and Gly residue. The resulting threonine carboxyl end of the protein is covalently attached to a pentaglycine cross-bridge of peptidoglycan. =
Synonyms
C60.001, sortase A, sortase A transpeptidase, sortase SrtA, sortase transpeptidase, SrtA, SrtA protein, SrtA sortase
ECTree
Advanced search results
Molecular Weight
Molecular Weight on EC 3.4.22.70 - sortase A
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
16595
-
x * 16595, SrtDELTAN59, electrospray ionization mass spectrometry
23900
-
x * 23900, truncated enzyme, calculated from amino acid sequence
24810
additional information
-
signal peptide, membrane anchor and a shorter linker domain of sortase enzymes display no amino acid conservation. The core residue, SrtA residues 60-206, is present in all sortase homologs examined, suggesting that this domain may comprise the catalytically active domain