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3.4.22.70: sortase A

This is an abbreviated version!
For detailed information about sortase A, go to the full flat file.

Word Map on EC 3.4.22.70

Reaction

The enzyme catalyses a cell wall sorting reaction in which a surface protein with a sorting signal containing a LPXTG motif is cleaved between the Thr and Gly residue. The resulting threonine carboxyl end of the protein is covalently attached to a pentaglycine cross-bridge of peptidoglycan. =

Synonyms

C60.001, sortase A, sortase A transpeptidase, sortase SrtA, sortase transpeptidase, SrtA, SrtA protein, SrtA sortase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.70 sortase A

KM Value

KM Value on EC 3.4.22.70 - sortase A

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00824 - 0.0168
Abz-LPETG-Dap(Dnp)
5.5
Abz-LPETG-Dap(Dnp)-NH2
1.18
agmatine
-
at 37°C, pH not specified in the publication, transpeptidation reaction
4.69 - 13.7
aminobenzoyl-LPETGG-diaminopropionic acid(dinitrophenol)-NH2
0.013 - 0.014
Dabcyl-QALPETGEE-Edans
5.6
Dnp-AQALPETGEE-NH2
-
-
0.041 - 0.2
Gly-Gly-Gly
0.14
Gly5
-
37°C, pH 7.5
0.79 - 11.2
N-(2-aminobenzoyl)-L-leucyl-L-prolyl-L-alpha-glutamyl-L-threonylglycyl-3-(2,4-dinitroanilino)-L-alaninamide
0.02 - 0.117
o-aminobenzoyl-Leu-Pro-Glu-Thr-Gly-2,4-dinitrophenyl ester
0.035 - 0.038
o-aminobenzoyl-LPETG-2,4-dinitrophenyl
0.00013 - 0.0087
o-aminobenzoyl-LPETG-2,4-dinitrophenyl ester
1.59
YALPETGK
-
at 37°C, pH not specified in the publication
additional information
additional information
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-
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