3.4.22.70: sortase A
This is an abbreviated version!
For detailed information about sortase A, go to the full flat file.
Word Map on EC 3.4.22.70
-
3.4.22.70
-
aureus
-
staphylococcus
-
lpxtg
-
streptococcus
-
peptidoglycan
-
transpeptidation
-
sortase-mediated
-
a-mediated
-
adhesins
-
bioconjugation
-
antivirulence
-
mutans
-
anti-infective
-
pilins
-
transpeptidases
-
oligoglycine
-
cross-bridges
-
pentaglycine
-
wall-anchored
-
molecular biology
-
azide-alkyne
-
analysis
-
biotechnology
-
drug development
-
synthesis
-
medicine
- 3.4.22.70
- aureus
- staphylococcus
-
lpxtg
- streptococcus
- peptidoglycan
-
transpeptidation
-
sortase-mediated
-
a-mediated
- adhesins
-
bioconjugation
-
antivirulence
- mutans
-
anti-infective
- pilins
- transpeptidases
-
oligoglycine
-
cross-bridges
- pentaglycine
-
wall-anchored
- molecular biology
-
azide-alkyne
- analysis
- biotechnology
- drug development
- synthesis
- medicine
Reaction
The enzyme catalyses a cell wall sorting reaction in which a surface protein with a sorting signal containing a LPXTG motif is cleaved between the Thr and Gly residue. The resulting threonine carboxyl end of the protein is covalently attached to a pentaglycine cross-bridge of peptidoglycan. =
Synonyms
C60.001, sortase A, sortase A transpeptidase, sortase SrtA, sortase transpeptidase, SrtA, SrtA protein, SrtA sortase
ECTree
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IC50 Value
IC50 Value on EC 3.4.22.70 - sortase A
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0.275
(1E)-N'-[(1E)-(4-[(E)-[(diaminomethylene)hydrazono]methyl]phenyl)methylene]ethanehydrazonamide
Staphylococcus aureus
-
-
0.133
(2-methyl-1H-indol-3-yl)(oxo)acetic acid
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.15
(2E)-2-(2-furoyl)-3-[(methyl[4-[(5-nitropyridin-2-yl)oxy]phenyl]oxido-l4-sulfanylidene)amino]acrylonitrile
Staphylococcus aureus
-
-
0.111
(2E)-3-(2-furyl)-N-[3-(hydroxymethyl)-4-morpholin-4-ylphenyl]acrylamide
Staphylococcus aureus
-
-
0.4
(2E)-3-[(methyl[4-[(5-nitropyridin-2-yl)oxy]phenyl]oxido-l4-sulfanylidene)amino]-2-(2-thienylcarbonyl)acrylonitrile
Staphylococcus aureus
-
-
0.125
(2E)-4-([4-[(2-hydroxybenzoyl)amino]phenyl]amino)-4-oxobut-2-enoic acid
Staphylococcus aureus
-
-
0.107
(2E)-N-(3-formyl-4-morpholin-4-ylphenyl)-3-(2-furyl)acrylamide
Staphylococcus aureus
-
-
0.077
(2E)-N-(3-formyl-4-morpholin-4-ylphenyl)-3-(2-thienyl)acrylamide
Staphylococcus aureus
-
-
0.073
(2E)-N-[3-(hydroxymethyl)-4-morpholin-4-ylphenyl]-3-(2-thienyl)acrylamide
Staphylococcus aureus
-
-
0.009244
(2Z)-3-(2,5-dimethoxyphenyl)-2-(4-methoxyphenyl)acrylonitrile
Staphylococcus aureus
-
IC50: 0.009244 mM
0.0362
(2Z)-3-(2-methoxyphenyl)-2-(4-methoxyphenyl)acrylonitrile
Staphylococcus aureus
-
IC50: 0.0362 mM
0.02296
(2Z)-3-(3,4-dimethoxyphenyl)-2-(4-methoxyphenyl)acrylonitrile
Staphylococcus aureus
-
IC50: 0.02296 mM
0.025463
(2Z)-3-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)acrylonitrile
Staphylococcus aureus
-
IC50: 0.025463 mM
0.0174
(2Z)-3-(3-methoxyphenyl)-2-(4-methoxyphenyl)acrylonitrile
Staphylococcus aureus
-
IC50: 0.0174 mM
0.0052
(4E)-5-methyl-4-[[(4-nitrophenyl)amino]methylidene]-2-phenyl-2,4-dihydro-3H-pyrazole-3-thione
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.119
(5Z)-3-(2,4-dimethylphenyl)-5-(3-nitrobenzylidene)-2-thioxo-1,3-thiazolidin-4-one
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
1
(5Z)-3-(3-chlorophenyl)-5-(4-methyl-3-nitrobenzylidene)-2-thioxo-1,3-thiazolidin-4-one
Staphylococcus aureus
-
IC50 above 1.0 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.492
(5Z)-3-benzyl-5-benzylidene-2-thioxo-1,3-thiazolidin-4-one
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.104
(5Z)-3-ethyl-5-(2-nitrobenzylidene)-2-thioxo-1,3-thiazolidin-4-one
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.0037
(5Z)-5-(3-bromo-2-hydroxy-5-nitrobenzylidene)-3-(2,4-dimethylphenyl)-2-thioxo-1,3-thiazolidin-4-one
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.017
(5Z)-5-(3-bromo-2-hydroxy-5-nitrobenzylidene)-3-(3-chlorophenyl)-2-thioxo-1,3-thiazolidin-4-one
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.015
(5Z)-5-(3-bromo-2-hydroxy-5-nitrobenzylidene)-3-(3-methylphenyl)-2-thioxo-1,3-thiazolidin-4-one
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.012
(5Z)-5-(3-bromo-2-hydroxy-5-nitrobenzylidene)-3-(4-nitrophenyl)-2-thioxo-1,3-thiazolidin-4-one
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.014
(5Z)-5-(3-bromo-2-hydroxy-5-nitrobenzylidene)-3-phenyl-2-thioxo-1,3-thiazolidin-4-one
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.035
(5Z)-5-(3-bromo-4-hydroxy-5-nitrobenzylidene)-3-(2,4-dimethylphenyl)-2-thioxo-1,3-thiazolidin-4-one
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.109
(5Z)-5-(3-chlorobenzylidene)-3-ethyl-2-thioxo-1,3-thiazolidin-4-one
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.199
(5Z)-5-benzylidene-3-(prop-2-en-1-yl)-2-thioxo-1,3-thiazolidin-4-one
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.405
(5Z)-5-benzylidene-3-methyl-2-thioxo-1,3-thiazolidin-4-one
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.186
(5Z)-5-benzylidene-3-propyl-2-thioxo-1,3-thiazolidin-4-one
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.0106
1-phenyl-2,3,4,9-tetrahydro-1H-beta-carbolin-7-ol
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.097
1-phenyl-4,9-dihydro-3H-beta-carboline
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.069
1H-indol-3-yl(oxo)acetic acid
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.174
2-(1H-indol-3-yl)-2-oxo-N-phenylacetamide
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.061
2-(2-methyl-1H-indol-3-yl)-2-oxo-N-phenylacetamide
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.301
2-(3,5-dichlorophenyl)-4-(ethylsulfanyl)-5-sulfanylpyridazin-3(2H)-one
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.166
2-(3,5-dichlorophenyl)-5-ethoxy-4-sulfanylpyridazin-3(2H)-one
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.05
2-(3-bromophenyl)-4,5-dichloropyridazin-3(2H)-one
Staphylococcus aureus
-
IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.05
2-(3-bromophenyl)-4-(ethylsulfanyl)-5-sulfanylpyridazin-3(2H)-one
Staphylococcus aureus
-
IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.05
2-(3-bromophenyl)-4-chloro-5-ethoxypyridazin-3(2H)-one
Staphylococcus aureus
-
IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.05
2-(3-bromophenyl)-5-chloro-4-ethoxypyridazin-3(2H)-one
Staphylococcus aureus
-
IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.05
2-(3-bromophenyl)-5-chloro-4-methoxypyridazin-3(2H)-one
Staphylococcus aureus
-
IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.0045
2-(3-chlorophenyl)-4-methoxy-5-sulfanylpyridazin-3(2H)-one
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.00611
2-(3-oxo-1,2-benzothiazol-2(3H)-yl)-N-(tricyclo[3.3.1.13,7]dec-1-yl)acetamide
Staphylococcus aureus
-
pH 7.5, 37°C, recombinant His6-tagged truncated enzyme mutant variant SrtADELTA59
0.05
2-(4-nitrophenyl)-4,5-dichloropyridazin-3-one
Staphylococcus aureus
-
IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.0179
2-cyclohexyl-4-(ethylsulfanyl)-5-sulfanylpyridazin-3(2H)-one
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.05
2-ethyl-4-hydroxy-5-(methylsulfanyl)pyridazin-3(2H)-one
Staphylococcus aureus
-
IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.226
2-hydroxy-N-[4-[([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]phenyl]benzamide
Staphylococcus aureus
-
-
0.105
2-morpholin-4-yl-5-[[(2E)-3-(2-thienyl)prop-2-enoyl]amino]benzamide
Staphylococcus aureus
-
-
0.05
2-phenyl-4,5-dichloro-pyridazin-3-one
Staphylococcus aureus
-
IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.19
3,3,3-trifluoro-1-(phenylsulfonyl)-1-propene
Staphylococcus aureus
-
IC50: 0.19 mM, irreversible
0.0973
3,5-bis[[2-(4-nitrophenyl)-2-oxoethyl]thio]isothiazole-4-carbonitrile
Staphylococcus aureus
-
-
0.0128
3-(3-oxo-1,2-benzothiazol-2(3H)-yl)propanoic acid
Staphylococcus aureus
-
pH 7.5, 37°C, recombinant His6-tagged truncated enzyme mutant variant SrtADELTA75
0.061
4,5-dichloro-2-(3,5-dichlorophenyl)pyridazin-3(2H)-one
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.05
4,5-dichloro-2-(3-fluorophenyl)pyridazin-3(2H)-one
Staphylococcus aureus
-
IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.05
4,5-dichloro-2-(3-methylphenyl)pyridazin-3(2H)-one
Staphylococcus aureus
-
IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.05
4,5-dichloro-2-cyclohexylpyridazin-3(2H)-one
Staphylococcus aureus
-
IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.05
4-(benzyloxy)-5-hydroxy-2-phenylpyridazin-3(2H)-one
Staphylococcus aureus
-
IC50 above 0.05 mM,
0.0055
4-(ethylsulfanyl)-2-(3-fluorophenyl)-5-sulfanylpyridazin-3(2H)-one
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.0033
4-(ethylsulfanyl)-2-(3-methylphenyl)-5-sulfanylpyridazin-3(2H)-one
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.03
4-(ethylsulfanyl)-2-(4-nitrophenyl)-5-sulfanylpyridazin-3(2H)-one
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.0014
4-(ethylsulfanyl)-2-phenyl-5-sulfanylpyridazin-3(2H)-one
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.05
4-(ethylsulfanyl)-5-hydroxy-2-phenylpyridazin-3(2H)-one
Staphylococcus aureus
-
IC50 above 0.05 mM,
0.05
4-chloro-2-(3,5-dichlorophenyl)-5-ethoxypyridazin-3(2H)-one
Staphylococcus aureus
-
IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.05
4-chloro-2-cyclohexyl-5-ethoxypyridazin-3(2H)-one
Staphylococcus aureus
-
IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.05
4-chloro-5-(methylsulfanyl)-2-phenylpyridazin-3(2H)-one
Staphylococcus aureus
-
IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.05
4-chloro-5-ethoxy-2-(3-fluorophenyl)pyridazin-3(2H)-one
Staphylococcus aureus
-
IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.05
4-chloro-5-ethoxy-2-(3-methylphenyl)pyridazin-3(2H)-one
Staphylococcus aureus
-
IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.219
4-chloro-5-ethoxy-2-(4-nitrophenyl)pyridazin-3(2H)-one
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.001
4-chloro-5-ethoxy-2-phenylpyridazin-3-one
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.0002
4-ethoxy-2-phenyl-5-sulfanylpyridazin-3(2H)-one
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.013
4-ethoxy-5-mercapto-2-phenylpyridazin-3-one
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.05
4-hydroxy-5-(methylsulfanyl)-2-phenylpyridazin-3(2H)-one
Staphylococcus aureus
-
IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.1125
4-hydroxymercuribenzoate
Streptococcus mutans
-
pH and temperature not specified in the publication
0.05
5-chloro-2-(3,5-dichlorophenyl)-4-ethoxypyridazin-3(2H)-one
Staphylococcus aureus
-
IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.05
5-chloro-2-(3,5-dichlorophenyl)-4-methoxypyridazin-3(2H)-one
Staphylococcus aureus
-
IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.05
5-chloro-2-(3-fluorophenyl)-4-methoxypyridazin-3(2H)-one
Staphylococcus aureus
-
IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.05
5-chloro-2-cyclohexyl-4-ethoxypyridazin-3(2H)-one
Staphylococcus aureus
-
IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.05
5-chloro-2-cyclohexyl-4-methoxypyridazin-3(2H)-one
Staphylococcus aureus
-
IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.05
5-chloro-4-ethoxy-2-(3-fluorophenyl)pyridazin-3(2H)-one
Staphylococcus aureus
-
IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.05
5-chloro-4-ethoxy-2-(3-methylphenyl)pyridazin-3(2H)-one
Staphylococcus aureus
-
IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.05
5-chloro-4-ethoxy-2-(4-nitrophenyl)pyridazin-3(2H)-one
Staphylococcus aureus
-
IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.05
5-chloro-4-ethoxy-2-phenylpyridazin-3-one
Staphylococcus aureus
-
IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.05
5-chloro-4-methoxy-2-(3-methylphenyl)pyridazin-3(2H)-one
Staphylococcus aureus
-
IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.05
5-chloro-4-methoxy-2-phenylpyridazin-3(2H)-one
Staphylococcus aureus
-
IC50 above 0.05 mM, in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.0057
5-ethoxy-2-(3-fluorophenyl)-4-sulfanylpyridazin-3(2H)-one
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.0031
5-ethoxy-2-(3-methylphenyl)-4-sulfanylpyridazin-3(2H)-one
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.0044
5-ethoxy-2-phenyl-4-sulfanylpyridazin-3(2H)-one
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.05
5-hydroxy-4-methoxy-2-phenylpyridazin-3(2H)-one
Staphylococcus aureus
-
IC50 above 0.05 mM,
0.0093
5-methoxy-2-phenyl-4-sulfanylpyridazin-3(2H)-one
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.181
5-[[(2E)-3-(2-furyl)prop-2-enoyl]amino]-2-morpholin-4-ylbenzoic acid
Staphylococcus aureus
-
-
0.067
6-hydroxydihydro-beta-carboline
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.0115
7-methoxy-1-phenyl-2,3,4,9-tetrahydro-1H-beta-carboline
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.025
7-methoxy-1-phenyl-4,9-dihydro-3H-beta-carboline
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.0015
bis(4-ethoxy-2-phenyl-5-pyridazyl)disulfide
Staphylococcus aureus
-
in 20 mM HEPES, 5 mM CaCl2, 0.05% (v/v) Tween-20, pH 7.5, at 25°C
0.00113
cis-1,2-bis(phenylsulfonyl)ethylene
Staphylococcus aureus
-
IC50: 0.00113 mM, irreversible
0.123
galangin
Staphylococcus aureus
-
IC50 for recombinant SrtA(DELTA24): 0.123 mM, no antibacterial activity against Staphylococcus aureus
0.1179
galangin-3-methyl ether
Staphylococcus aureus
-
IC50 for recombinant SrtA(DELTA24): 0.1179 mM, no antibacterial activity against Staphylococcus aureus
0.05886
isorhamnetin
Staphylococcus aureus
-
IC50 for recombinant SrtA(DELTA24): 0.05886 mM, no antibacterial activity against Staphylococcus aureus
0.0621
isorhamnetin 3-O-beta-D-rutinoside
Streptococcus mutans
-
pH and temperature not specified in the publication
0.07794
kaempferol
Staphylococcus aureus
-
IC50 for recombinant SrtA(DELTA24): 0.07794 mM, no antibacterial activity against Staphylococcus aureus
0.0607
kaempferol-3-rutinoside
Streptococcus mutans
-
pH and temperature not specified in the publication
0.0943
maltol 3-O-(4'-O-p-coumaroyl-6'-O-(3-hydroxy-3-methylglutaroyl))-beta-glucopyranoside
Streptococcus mutans
-
pH and temperature not specified in the publication
0.0586
maltol-3-O-(4'-O-cis-p-coumaroyl-6'-O-(3-hydroxy-3-methylglutaroyl))-beta-glucopyranoside
Streptococcus mutans
-
pH and temperature not specified in the publication
2.2
methyl (2S,3S,7aS)-2-ethenesulfonyl-5-oxo-3-phenyltetrahydropyrrolizine-7a-carboxylate
Staphylococcus aureus
-
pH 7.5, 37°C
2.47
methyl (2S,3S,7aS)-2-ethenesulfonyl-5-oxo-3-pyridin-3-yl-tetrahydropyrrolizine-7a-carboxylate
Staphylococcus aureus
-
pH 7.5, 37°C
2.68
methyl (2S,3S,7aS)-3-(3,4-dimethoxyphenyl)-2-ethenesulfonyl-5-oxotetrahydropyrrolizine-7a-carboxylate
Staphylococcus aureus
-
pH 7.5, 37°C
1.86
methyl (2S,4S,5S)-4-ethenesulfonyl-2-(2-methoxycarbonylethyl)-5-pyridin-3-yl-pyrrolidine-2-carboxylate
Staphylococcus aureus
-
pH 7.5, 37°C
1.32
methyl (4S,5S)-4-(ethenylsulfonyl)-5-(2-fluorophenyl)-L-prolinate
Staphylococcus aureus
-
pH 7.5, 37°C
1.04
methyl (4S,5S)-4-(ethenylsulfonyl)-5-(3-fluorophenyl)-L-prolinate
Staphylococcus aureus
-
pH 7.5, 37°C
0.85
methyl (4S,5S)-4-(ethenylsulfonyl)-5-phenyl-L-prolinate
Staphylococcus aureus
-
pH 7.5, 37°C
0.071
methyl 2-morpholin-4-yl-5-[[(2E)-3-(2-thienyl)prop-2-enoyl]amino]benzoate
Staphylococcus aureus
-
-
0.00508
methyl 3-(3-(3-oxobenzo[d]isothiazol-2(3H)-yl)propanamido)adamantane-1-carboxylate
Staphylococcus aureus
-
pH 7.5, 37°C, recombinant His6-tagged truncated enzyme mutant variant SrtADELTA66
0.00506
methyl 3-(3-(4-fluoro-3-oxobenzo[d]isothiazol-2(3H)-yl)propanamido)adamantane-1-carboxylate
Staphylococcus aureus
-
pH 7.5, 37°C, recombinant His6-tagged truncated enzyme mutant variant SrtADELTA71
0.058
methyl 5-[[(2E)-3-(2-furyl)prop-2-enoyl]amino]-2-morpholin-4-ylbenzoate
Staphylococcus aureus
-
-
0.03739
morin
Staphylococcus aureus
-
IC50 for recombinant SrtA(DELTA24): 0.03739 mM, no antibacterial activity against Staphylococcus aureus
0.04403
myricetin
Staphylococcus aureus
-
IC50 for recombinant SrtA(DELTA24): 0.04403 mM, no antibacterial activity against Staphylococcus aureus
0.0038
N'-(2-(3-oxobenzo[d]isothiazol-2(3H)-yl)acetyl)adamantane-1-carbohydrazide
Staphylococcus aureus
-
pH 7.5, 37°C, recombinant His6-tagged truncated enzyme mutant variant SrtADELTA72
0.00422
N'-(3-(3-oxobenzo[d]isothiazol-2(3H)-yl)propanoyl)adamantane-1-carbohydrazide
Staphylococcus aureus
-
pH 7.5, 37°C, recombinant His6-tagged truncated enzyme mutant variant SrtADELTA73
0.00339
N'-(3-(4-fluoro-3-oxobenzo[d]isothiazol-2(3H)-yl)propanoyl)adamantane-1-carbohydrazide
Staphylococcus aureus
-
pH 7.5, 37°C, recombinant His6-tagged truncated enzyme mutant variant SrtADELTA74
0.00499
N-(3,5-dimethyladamantan-1-yl)-3-(3-oxobenzo[d]isothiazol-2(3H)-yl)acetamide
Staphylococcus aureus
-
pH 7.5, 37°C, recombinant His6-tagged truncated enzyme mutant variant SrtADELTA60
0.00462
N-(3,5-dimethyladamantan-1-yl)-3-(3-oxobenzo[d]isothiazol-2(3H)-yl)propanamide
Staphylococcus aureus
-
pH 7.5, 37°C, recombinant His6-tagged truncated enzyme mutant variant SrtADELTA63
0.0041
N-(3,5-dimethyladamantan-1-yl)-3-(4-fluoro-3-oxobenzo[d]isothiazol-2(3H)-yl)propanamide
Staphylococcus aureus
-
pH 7.5, 37°C, recombinant His6-tagged truncated enzyme mutant variant SrtADELTA68
0.00387
N-(3-hydroxy-5,7-dimethyladamantan-1-yl)-2-(3-oxobenzo[d]isothiazol-2(3H)-yl)acetamide
Staphylococcus aureus
-
pH 7.5, 37°C, recombinant His6-tagged truncated enzyme mutant variant SrtADELTA61
0.00706
N-(3-hydroxy-5,7-dimethyladamantan-1-yl)-3-(3-oxobenzo[d]isothiazol-2(3H)-yl)propanamide
Staphylococcus aureus
-
pH 7.5, 37°C, recombinant His6-tagged truncated enzyme mutant variant SrtADELTA64
0.00396
N-(3-hydroxy-5,7-dimethyladamantan-1-yl)-3-(4-fluoro-3-oxobenzo[d]isothiazol-2(3H)-yl)propanamide
Staphylococcus aureus
-
pH 7.5, 37°C, recombinant His6-tagged truncated enzyme mutant variant SrtADELTA69
0.00644
N-(3-hydroxyadamantan-1-yl)-3-(3-oxobenzo[d]isothiazol-2(3H)-yl)propanamide
Staphylococcus aureus
-
pH 7.5, 37°C, recombinant His6-tagged truncated enzyme mutant variant SrtADELTA65
0.00626
N-(3-ydroxyadamantan-1-yl)-3-(4-fluoro-3-oxobenzo[d]isothiazol-2(3H)-yl)propanamide
Staphylococcus aureus
-
pH 7.5, 37°C, recombinant His6-tagged truncated enzyme mutant variant SrtADELTA70
0.00401
N-(adamantan-1-yl)-3-(4-fluoro-3-oxobenzo[d]isothiazol-2(3H)-yl)propanamide
Staphylococcus aureus
-
pH 7.5, 37°C, recombinant His6-tagged truncated enzyme mutant variant SrtADELTA67
0.00381
N-adamantan-1-yl-3-(3-oxobenzo[d]isothiazol-2(3H)-yl)propanamide
Staphylococcus aureus
-
pH 7.5, 37°C, recombinant His6-tagged truncated enzyme mutant variant SrtADELTA62
0.042
p-hydroxymercuribenzoic acid
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.0527
quercetin
Staphylococcus aureus
-
IC50 for recombinant SrtA(DELTA24): 0.0527 mM, no antibacterial activity against Staphylococcus aureus
0.05361
quercetin-3,3'-dimethyl ether
Staphylococcus aureus
-
IC50 for recombinant SrtA(DELTA24): 0.05361 mM, no antibacterial activity against Staphylococcus aureus
additional information
additional information
Staphylococcus aureus
-
IC50 for aaptamine is 0.0235 mg/ml, IC50 for isoaaptamine is 0.0037 mg/ml, IC50 for demethylaaptamine is 0.0172 mg/ml, IC50 for demethyloxyaaptamine is 0.0201 mg/ml, IC50 for berberine chloride is 0.0087 mg/ml
-
0.736
1-(3,4-dichlorophenyl)-3-(dimethylamino)propan-1-one
Staphylococcus aureus
-
pH 7.5, 37°C, recombinant His6-tagged truncated enzyme mutant variant SrtADELTA75
0.0802
Staphylococcus aureus
-
-
0.0907
ethyl 4-[3-(4-bromophenyl)-3-oxopropyl]piperazine-1-carboxylate
Staphylococcus aureus
-
-
0.0169
Staphylococcus aureus
-
pH 7.5, 37°C, recombinant His6-tagged truncated enzyme mutant variant SrtADELTA75