Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.4.22.69: SARS coronavirus main proteinase

This is an abbreviated version!
For detailed information about SARS coronavirus main proteinase, go to the full flat file.

Word Map on EC 3.4.22.69

Reaction

TSAVLQSGFRK-NH2
+
H2O
=
TSAVLQ
 +
SGFRK-NH2

Synonyms

2019-nCoV 3C-like protease, 3C-like cysteine protease, 3C-like peptidase, 3C-like protease, 3CL protease, 3CL-pro, 3cLpro, C30.004, chymotrypsin-like protease, coronavirus 3C-like protease, coronavirus M(pro), coronavirus main protease, main protease, MERS-CoV 3C-like protease, Mpro, nsp5, porcine transmissible gastroenteritis virus Mpro, protease Mpro, SARS 3C-like protease, SARS 3C-like proteinase, SARS 3CL protease, SARS 3CLpro, SARS coronavirus 3C-like protease, SARS coronavirus 3C-like proteinase, SARS coronavirus 3CL protease, SARS coronavirus main peptidase, SARS coronavirus main protease, SARS coronavirus main proteinase, SARS coronavirus Mpro, SARS CoV main proteinase, SARS CoVMpro, SARS main protease, SARS Mpro, SARS-3CL protease, SARS-3CLpro, SARS-coronavirus 3CL protease, SARS-coronavirus main protease, SARS-CoV 3C-like peptidase, SARS-CoV 3C-like protease, SARS-CoV 3CL peptidase, SARS-CoV 3CL protease, SARS-CoV 3CLpro, SARS-CoV 3CLpro enzyme, SARS-CoV 3CLpro protease, SARS-CoV main protease, SARS-CoV Mpro, SARS-CoV nsp5-pp1a/pp1ab 3CL protease, SARS-CoV-2 3C-like protease, SARS-CoV-2 main protease, SARSCoV main protease, SARSCoV Mpro, severe acute respiratory syndrome coronavirus 3C-like protease, severe acute respiratory syndrome coronavirus 3CLpro, severe acute respiratory syndrome coronavirus main protease, severe acute respiratory syndrome coronavirus main proteinase, severe acute respiratory syndrome coronavirus Mpro, TGEV Mpro

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.69 SARS coronavirus main proteinase

Reference

topprint

Reference on EC 3.4.22.69 - SARS coronavirus main proteinase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Xu, T.; Ooi, A.; Lee, H.C.; Wilmouth, R.; Liu, D.X.; Lescar, J.
Structure of the SARS coronavirus main proteinase as an active C2 crystallographic dimer
Acta Crystallogr. Sect. F
61
964-966
2005
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Zhang, X.W.; Yap, Y.L.
Old drugs as lead compounds for a new disease? Binding analysis of SARS coronavirus main proteinase with HIV, psychotic and parasite drugs
Bioorg. Med. Chem.
12
2517-2521
2004
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Graziano, V.; McGrath, W.J.; DeGruccio, A.M.; Dunn, J.J.; Mangel, W.F.
Enzymatic activity of the SARS coronavirus main proteinase dimer
FEBS Lett.
580
2577-2583
2006
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Tan, J.; Verschueren, K.H.; Anand, K.; Shen, J.; Yang, M.; Xu, Y.; Rao, Z.; Bigalke, J.; Heisen, B.; Mesters, J.R.; Chen, K.; Shen, X.; Jiang, H.; Hilgenfeld, R.
pH-dependent conformational flexibility of the SARS-CoV main proteinase (M(pro)) dimer: molecular dynamics simulations and multiple X-ray structure analyses
J. Mol. Biol.
354
25-40
2005
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Graziano, V.; McGrath, W.J.; Yang, L.; Mangel, W.F.
SARS CoV main proteinase: The monomer-dimer equilibrium dissociation constant
Biochemistry
45
14632-14641
2006
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Goetz, D.H.; Choe, Y.; Hansell, E.; Chen, Y.T.; McDowell, M.; Jonsson, C.B.; Roush, B.C.; McKerrow, J.; Craik, C.S.
Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus
Biochemistry
46
8744-8752
2007
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Solowiej, J.; Thomson, J.A.; Ryan, K.; Luo, C.; He, M.; Lou, J.; Murray, B.W.
Steady-state and pre-steady-state kinetic evaluation of severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro cysteine protease: development of an ion-pair model for catalysis
Biochemistry
47
2617-2630
2008
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Hamill, P.; Hudson, D.; Kao, R.Y.; Chow, P.; Raj, M.; Xu, H.; Richer, M.J.; Jean, F.
Development of a red-shifted fluorescence-based assay for SARS-coronavirus 3CL protease: identification of a novel class of anti-SARS agents from the tropical marine sponge Axinella corrugata
Biol. Chem.
387
1063-1074
2006
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Chen, L.; Li, J.; Luo, C.; Liu, H.; Xu, W.; Chen, G.; Liew, O.W.; Zhu, W.; Puah, C.M.; Shen, X.; Jiang, H.
Binding interaction of quercetin-3-beta -galactoside and its synthetic derivatives with SARS-CoV 3CLpro: Structure-activity relationship studies reveal salient pharmacophore features
Bioorg. Med. Chem.
14
8295-8306
2006
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Niu, C.; Yin, J.; Zhang, J.; Vederas, J.C.; James, M.N.
Molecular docking identifies the binding of 3-chloropyridine moieties specifically to the S1 pocket of SARS-CoV Mpro
Bioorg. Med. Chem.
16
293-302
2008
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Ghosh, A.K.; Xi, K.; Grum-Tokars, V.; Xu, X.; Ratia, K.; Fu, W.; Houser, K.V.; Baker, S.C.; Johnson, M.E.; Mesecar, A.D.
Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors
Bioorg. Med. Chem. Lett.
17
5876-5880
2007
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Chang, H.; Chou, C.; Chang, G.
Reversible unfolding of the severe acute respiratory syndrome coronavirus main protease in guanidinium chloride
Biophys. J.
92
1374-1383
2007
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Wu, C.; King, K.; Kuo, C.; Fang, J.; Wu, Y.; Ho, M.; Liao, C.; Shie, J.; Liang, P.; Wong, C.
Stable benzotriazole esters as mechanism-based inactivators of the severe acute respiratory syndrome 3CL protease
Chem. Biol.
13
261-268
2006
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Shao, Y.; Yang, W.; Peng, H.; Hsu, M.; Tsai, K.; Kuo, T.; Wang, A.H.; Liang, P.; Lin, C.; Yang, A.; Wong, C.
Structure-based design and synthesis of highly potent SARS-CoV 3CL protease inhibitors
Chembiochem
8
1654-1657
2007
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Lai, L.; Han, X.; Chen, H.; Wei, P.; Huang, C.; Liu, S.; Fan, K.; Zhou, L.; Liu, Z.; Pei, J.; Liu, Y.
Quaternary structure, substrate selectivity and inhibitor design for SARS 3C-like proteinase
Curr. Pharm. Des.
12
4555-4564
2006
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Liang, P.
Characterization and inhibition of SARS-coronavirus main protease
Curr. Top. Med. Chem.
6
361-376
2006
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Shi, J.; Song, J.
The catalysis of the SARS 3C-like protease is under extensive regulation by its extra domain
FEBS J.
273
1035-1045
2006
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Chen, H.; Wei, P.; Huang, C.; Tan, L.; Liu, Y.; Lai, L.
Only one protomer is active in the dimer of SARS 3C-like proteinase
J. Biol. Chem.
281
13894-13898
2006
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Chen, S.; Hu, T.; Zhang, J.; Chen, J.; Chen, K.; Ding, J.; Jiang, H.; Shen, X.
Mutation of Gly-11 on the dimer interface results in the complete crystallographic dimer dissociation of severe acute respiratory syndrome coronavirus 3C-like protease. Crystal structure with molecular dynamics simulations
J. Biol. Chem.
283
554-564
2008
Alphacoronavirus
Manually annotated by BRENDA team
Yang, S.; Chen, S.; Hsu, M.; Wu, J.; Tseng, C.K.; Liu, Y.; Chen, H.; Kuo, C.; Wu, C.; Chang, L.; Chen, W.; Liao, S.; Chang, T.; Hung, H.; Shr, H.; Liu, C.; Huang, Y.; Chang, L.; Hsu, J.; Peters, C.J.; Wang, A.H.; Hsu, M.
Synthesis, crystal structure, structure-activity relationships, and antiviral activity of a potent SARS coronavirus 3CL protease inhibitor
J. Med. Chem.
49
4971-4980
2006
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Lu, I.; Mahindroo, N.; Liang, P.; Peng, Y.; Kuo, C.; Tsai, K.; Hsieh, H.; Chao, Y.; Wu, S.
Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease
J. Med. Chem.
49
5154-5161
2006
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Wen, C.; Kuo, Y.; Jan, J.; Liang, P.; Wang, S.; Liu, H.; Lee, C.; Chang, S.; Kuo, C.; Lee, S.; Hou, C.; Hsiao, P.; Chien, S.; Shyur, L.; Yang, N.
Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus
J. Med. Chem.
50
4087-4095
2007
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Lee, T.; Cherney, M.M.; Liu, J.; James, K.E.; Powers, J.C.; Eltis, L.D.; James, M.N.
Crystal structures reveal an induced-fit binding of a substrate-like aza-peptide epoxide to SARS coronavirus main peptidase
J. Mol. Biol.
366
916-932
2007
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Yin, J.; Niu, C.; Cherney, M.M.; Zhang, J.; Huitema, C.; Eltis, L.D.; Vederas, J.C.; James, M.N.
A mechanistic view of enzyme inhibition and peptide hydrolysis in the active site of the SARS-CoV 3C-like peptidase
J. Mol. Biol.
371
1060-1074
2007
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Zheng, K.; Ma, G.; Zhou, J.; Min, Z.; Zhao, W.; Jiang, Y.; Yu, Q.; Feng, J.
Insight into the activity of SARS main protease: molecular dynamics study of dimeric and monomeric form of enzyme
Proteins Struct. Funct. Bioinform.
66
467-479
2007
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Lin, P.Y.; Chou, C.Y.; Chang, H.C.; Hsu, W.C.; Chang, G.G.
Correlation between dissociation and catalysis of SARS-CoV main protease
Arch. Biochem. Biophys.
472
34-42
2008
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Fan, K.; Wei, P.; Feng, Q.; Chen, S.; Huang, C.; Ma, L.; Lai, B.; Pei, J.; Liu, Y.; Chen, J.; Lai, L.J.
Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase
Biol. Chem.
279
1637-1642
2004
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Zhang, J.; Huitema, C.; Niu, C.; Yin, J.; James, M.N.; Eltis, L.D.; Vederas, J.C.
Aryl methylene ketones and fluorinated methylene ketones as reversible inhibitors for severe acute respiratory syndrome (SARS) 3C-like proteinase
Bioorg. Chem.
36
229-240
2008
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Mukherjee, P.; Desai, P.; Ross, L.; White, E.L.; Avery, M.A.
Structure-based virtual screening against SARS-3CL(pro) to identify novel non-peptidic hits
Bioorg. Med. Chem.
16
4138-4149
2008
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Shao, Y.M.; Yang, W.B.; Kuo, T.H.; Tsai, K.C.; Lin, C.H.; Yang, A.S.; Liang, P.H.; Wong, C.H.
Design, synthesis, and evaluation of trifluoromethyl ketones as inhibitors of SARS-CoV 3CL protease
Bioorg. Med. Chem.
16
4652-4660
2008
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Akaji, K.; Konno, H.; Onozuka, M.; Makino, A.; Saito, H.; Nosaka, K.
Evaluation of peptide-aldehyde inhibitors using R188I mutant of SARS 3CL protease as a proteolysis-resistant mutant
Bioorg. Med. Chem.
16
9400-9408
2008
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Ghosh, A.K.; Gong, G.; Grum-Tokars, V.; Mulhearn, D.C.; Baker, S.C.; Coughlin, M.; Prabhakar, B.S.; Sleeman, K.; Johnson, M.E.; Mesecar, A.D.
Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors
Bioorg. Med. Chem. Lett.
18
5684-5688
2008
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Phakthanakanok, K.; Ratanakhanokchai, K.; Kyu, K.L.; Sompornpisut, P.; Watts, A.; Pinitglang, S.
A computational analysis of SARS cysteine proteinase-octapeptide substrate interaction: implication for structure and active site binding mechanism
BMC Bioinformatics
10 Suppl 1
S48
2009
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Bacha, U.; Barrila, J.; Gabelli, S.B.; Kiso, Y.; Mario Amzel, L.; Freire, E.
Development of broad-spectrum halomethyl ketone inhibitors against coronavirus main protease 3CL(pro)
Chem. Biol. Drug Des.
72
34-49
2008
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Yang, Q.; Chen, L.; He, X.; Gao, Z.; Shen, X.; Bai, D.
Design and synthesis of cinanserin analogs as severe acute respiratory syndrome coronavirus 3CL protease inhibitors
Chem. Pharm. Bull.
56
1400-1405
2008
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Kuo, C.J.; Liu, H.G.; Lo, Y.K.; Seong, C.M.; Lee, K.I.; Jung, Y.S.; Liang, P.H.
Individual and common inhibitors of coronavirus and picornavirus main proteases
FEBS Lett.
583
549-555
2009
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Chen, S.; Zhang, J.; Hu, T.; Chen, K.; Jiang, H.; Shen, X.
Residues on the dimer interface of SARS coronavirus 3C-like protease: dimer stability characterization and enzyme catalytic activity analysis
J. Biochem.
143
525-536
2008
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Lee, C.C.; Kuo, C.J.; Ko, T.P.; Hsu, M.F.; Tsui, Y.C.; Chang, S.C.; Yang, S.; Chen, S.J.; Chen, H.C.; Hsu, M.C.; Shih, S.R.; Liang, P.H.; Wang, A.H.
Structural basis of inhibition specificities of 3C and 3C-like proteases by zinc-coordinating and peptidomimetic Compounds
J. Biol. Chem.
284
7646-7655
2009
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Taranto, A.G.; Carvalho, P.; Avery, M.A.
QM/QM studies for Michael reaction in coronavirus main protease (3CL Pro)
J. Mol. Graph. Model.
27
275-285
2008
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Zhong, N.; Zhang, S.; Zou, P.; Chen, J.; Kang, X.; Li, Z.; Liang, C.; Jin, C.; Xia, B.
Without its N-finger, the main protease of severe acute respiratory syndrome coronavirus can form a novel dimer through its C-terminal domain
J. Virol.
82
4227-4234
2008
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Shi, J.; Sivaraman, J.; Song, J.
Mechanism for controlling the dimer-monomer switch and coupling dimerization to catalysis of the severe acute respiratory syndrome coronavirus 3C-like protease
J. Virol.
82
4620-4629
2008
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Chu, L.H.; Choy, W.Y.; Tsai, S.N.; Rao, Z.; Ngai, S.M.
Rapid peptide-based screening on the substrate specificity of severe acute respiratory syndrome (SARS) coronavirus 3C-like protease by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
Protein Sci.
15
699-709
2006
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Zhong, N.; Zhang, S.; Xue, F.; Kang, X.; Zou, P.; Chen, J.; Liang, C.; Rao, Z.; Jin, C.; Lou, Z.; Xia, B.
C-terminal domain of SARS-CoV main protease can form a 3D domain-swapped dimer
Protein Sci.
18
839-844
2009
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Regnier, T.; Sarma, D.; Hidaka, K.; Bacha, U.; Freire, E.; Hayashi, Y.; Kiso, Y.
New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CL(pro) inhibitors
Bioorg. Med. Chem. Lett.
19
2722-2727
2009
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Ryu, Y.B.; Park, S.J.; Kim, Y.M.; Lee, J.Y.; Seo, W.D.; Chang, J.S.; Park, K.H.; Rho, M.C.; Lee, W.S.
SARS-CoV 3CLpro inhibitory effects of quinone-methide triterpenes from Tripterygium regelii
Bioorg. Med. Chem. Lett.
20
1873-1876
2010
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Ramajayam, R.; Tan, K.P.; Liu, H.G.; Liang, P.H.
Synthesis, docking studies, and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL protease
Bioorg. Med. Chem. Lett.
20
3569-3572
2010
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Cheng, S.C.; Chang, G.G.; Chou, C.Y.
Mutation of Glu-166 blocks the substrate-induced dimerization of SARS coronavirus main protease
Biophys. J.
98
1327-1336
2010
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Luo, W.; Su, X.; Gong, S.; Qin, Y.; Liu, W.; Li, J.; Yu, H.; Xu, Q.
Anti-SARS coronavirus 3C-like protease effects of Rheum palmatum L. extracts
Biosci. Trends
3
124-126
2009
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Kuo, C.J.; Shih, Y.P.; Kan, D.; Liang, P.H.
Engineering a novel endopeptidase based on SARS 3CL(pro)
Biotechniques
47
1029-1032
2009
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Li, C.; Qi, Y.; Teng, X.; Yang, Z.; Wei, P.; Zhang, C.; Tan, L.; Zhou, L.; Liu, Y.; Lai, L.
Maturation mechanism of severe acute respiratory syndrome (SARS) coronavirus 3C-like proteinase
J. Biol. Chem.
285
28134-28140
2010
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Hu, T.; Zhang, Y.; Li, L.; Wang, K.; Chen, S.; Chen, J.; Ding, J.; Jiang, H.; Shen, X.
Two adjacent mutations on the dimer interface of SARS coronavirus 3C-like protease cause different conformational changes in crystal structure
Virology
388
324-334
2009
SARS coronavirus Tor2 (P0C6U8)
Manually annotated by BRENDA team
Zhu, L.; George, S.; Schmidt, M.F.; Al-Gharabli, S.I.; Rademann, J.; Hilgenfeld, R.
Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease
Antiviral Res.
92
204-212
2011
Severe acute respiratory syndrome-related coronavirus (P0C6U8), Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Barrila, J.; Gabelli, S.B.; Bacha, U.; Amzel, L.M.; Freire, E.
Mutation of Asn28 disrupts the dimerization and enzymatic activity of SARS 3CLpro
Biochemistry
49
4308-4317
2010
Severe acute respiratory syndrome-related coronavirus, Severe acute respiratory syndrome-related coronavirus Tor2
Manually annotated by BRENDA team
Okamoto, D.N.; Oliveira, L.C.; Kondo, M.Y.; Cezari, M.H.; Szeltner, Z.; Juhasz, T.; Juliano, M.A.; Polgar, L.; Juliano, L.; Gouvea, I.E.
Increase of SARS-CoV 3CL peptidase activity due to macromolecular crowding effects in the milieu composition
Biol. Chem.
391
1461-1468
2010
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Nguyen, T.T.; Ryu, H.J.; Lee, S.H.; Hwang, S.; Breton, V.; Rhee, J.H.; Kim, D.
Virtual screening identification of novel severe acute respiratory syndrome 3C-like protease inhibitors and in vitro confirmation
Bioorg. Med. Chem. Lett.
21
3088-3091
2011
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Ahn, T.; Kuo, C.; Liu, H.; Ha, D.; Liang, P.; Jung, Y.
Synthesis and evaluation of benzoquinolinone derivatives as SARS-CoV 3CL protease inhibitors
Bull. Korean Chem. Soc.
31
87-91
2010
Severe acute respiratory syndrome-related coronavirus
-
Manually annotated by BRENDA team
Akaji, K.; Konno, H.; Mitsui, H.; Teruya, K.; Shimamoto, Y.; Hattori, Y.; Ozaki, T.; Kusunoki, M.; Sanjoh, A.
Structure-based design, synthesis, and evaluation of peptide-mimetic SARS 3CL protease inhibitors
J. Med. Chem.
54
7962-7973
2011
Severe acute respiratory syndrome-related coronavirus (P0C6U8)
Manually annotated by BRENDA team
Chuck, C.; Chong, L.; Chen, C.; Chow, H.; Wan, D.; Wong, K.
Profiling of substrate specificity of SARS-CoV 3CLpro
PLoS ONE
5
e13197
2010
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Wu, C.G.; Cheng, S.C.; Chen, S.C.; Li, J.Y.; Fang, Y.H.; Chen, Y.H.; Chou, C.Y.
Mechanism for controlling the monomer-dimer conversion of SARS coronavirus main protease
Acta Crystallogr. Sect. D
69
747-755
2013
Severe acute respiratory syndrome-related coronavirus (P0C6U8), Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Paasche, A.; Zipper, A.; Schaefer, S.; Ziebuhr, J.; Schirmeister, T.; Engels, B.
Evidence for substrate binding-induced zwitterion formation in the catalytic Cys-His dyad of the SARS-CoV main protease
Biochemistry
53
5930-5946
2014
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Turlington, M.; Chun, A.; Tomar, S.; Eggler, A.; Grum-Tokars, V.; Jacobs, J.; Daniels, J.S.; Dawson, E.; Saldanha, A.; Chase, P.; Baez-Santos, Y.M.; Lindsley, C.W.; Hodder, P.; Mesecar, A.D.; Stauffer, S.R.
Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamidophenyl carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding
Bioorg. Med. Chem. Lett.
23
6172-6177
2013
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Thanigaimalai, P.; Konno, S.; Yamamoto, T.; Koiwai, Y.; Taguchi, A.; Takayama, K.; Yakushiji, F.; Akaji, K.; Kiso, Y.; Kawasaki, Y.; Chen, S.E.; Naser-Tavakolian, A.; Schoen, A.; Freire, E.; Hayashi, Y.
Design, synthesis, and biological evaluation of novel dipeptide-type SARS-CoV 3CL protease inhibitors: structure-activity relationship study
Eur. J. Med. Chem.
65
436-447
2013
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Thanigaimalai, P.; Konno, S.; Yamamoto, T.; Koiwai, Y.; Taguchi, A.; Takayama, K.; Yakushiji, F.; Akaji, K.; Chen, S.E.; Naser-Tavakolian, A.; Schoen, A.; Freire, E.; Hayashi, Y.
Development of potent dipeptide-type SARS-CoV 3CL protease inhibitors with novel P3 scaffolds: design, synthesis, biological evaluation, and docking studies
Eur. J. Med. Chem.
68
372-384
2013
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Muramatsu, T.; Kim, Y.T.; Nishii, W.; Terada, T.; Shirouzu, M.; Yokoyama, S.
Autoprocessing mechanism of severe acute respiratory syndrome coronavirus 3C-like protease (SARS-CoV 3CLpro) from its polyproteins
FEBS J.
280
2002-2013
2013
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Krichel, B.; Falke, S.; Hilgenfeld, R.; Redecke, L.; Uetrecht, C.
Processing of the SARS-CoV pp1a/ab nsp7-10 region
Biochem. J.
477
1009-1019
2020
Severe acute respiratory syndrome-related coronavirus (P0C6X7), Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Shimamoto, Y.; Hattori, Y.; Kobayashi, K.; Teruya, K.; Sanjoh, A.; Nakagawa, A.; Yamashita, E.; Akaji, K.
Fused-ring structure of decahydroisoquinoline as a novel scaffold for SARS 3CL protease inhibitor
Bioorg. Med. Chem.
23
876-890
2015
Severe acute respiratory syndrome-related coronavirus (P0C6X7)
Manually annotated by BRENDA team
Ohnishi, K.; Hattori, Y.; Kobayashi, K.; Akaji, K.
Evaluation of a non-prime site substituent and warheads combined with a decahydroisoquinolin scaffold as a SARS 3CL protease inhibitor
Bioorg. Med. Chem.
27
425-435
2019
Severe acute respiratory syndrome-related coronavirus (P0C6X7)
Manually annotated by BRENDA team
Yoshizawa, S.I.; Hattori, Y.; Kobayashi, K.; Akaji, K.
Evaluation of an octahydroisochromene scaffold used as a novel SARS 3CL protease inhibitor
Bioorg. Med. Chem.
28
115273
2020
Severe acute respiratory syndrome-related coronavirus (P0C6X7)
Manually annotated by BRENDA team
Konno, H.; Onuma, T.; Nitanai, I.; Wakabayashi, M.; Yano, S.; Teruya, K.; Akaji, K.
Synthesis and evaluation of phenylisoserine derivatives for the SARS-CoV 3CL protease inhibitor
Bioorg. Med. Chem. Lett.
27
2746-2751
2017
Severe acute respiratory syndrome-related coronavirus (P0C6X7)
Manually annotated by BRENDA team
Teruya, K.; Hattori, Y.; Shimamoto, Y.; Kobayashi, K.; Sanjoh, A.; Nakagawa, A.; Yamashita, E.; Akaji, K.
Structural basis for the development of SARS 3CL protease inhibitors from a peptide mimic to an aza-decaline scaffold
Biopolymers
106
391-403
2016
Severe acute respiratory syndrome-related coronavirus (P0C6X7)
Manually annotated by BRENDA team
Morse, J.; Lalonde, T.; Xu, S.; Liu, W.
Learning from the Past Possible urgent prevention and treatment options for severe acute respiratory infections caused by 2019-nCoV
ChemBioChem
21
730-738
2020
Severe acute respiratory syndrome-related coronavirus (P0C6X7)
Manually annotated by BRENDA team
Rahman, M.; Hosen, M.; Howlader, M.; Kabir, Y.
Lead molecule prediction and characterization for designing MERS-CoV 3C-like protease inhibitors An in silico approach
Curr. Comput. Aided Drug Des.
15
82-88
2019
Middle East respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Wang, L.; Bao, B.B.; Song, G.Q.; Chen, C.; Zhang, X.M.; Lu, W.; Wang, Z.; Cai, Y.; Li, S.; Fu, S.; Song, F.H.; Yang, H.; Wang, J.G.
Discovery of unsymmetrical aromatic disulfides as novel inhibitors of SARS-CoV main protease Chemical synthesis, biological evaluation, molecular docking and 3D-QSAR study
Eur. J. Med. Chem.
137
450-461
2017
Severe acute respiratory syndrome-related coronavirus (P0C6X7)
Manually annotated by BRENDA team
Chen, Y.W.; Yiu, C.B.; Wong, K.Y.
Prediction of the SARS-CoV-2 (2019-nCoV) 3C-like protease (3CL pro) structure virtual screening reveals velpatasvir, ledipasvir, and other drug repurposing candidates
F1000Res.
9
129
2020
Severe acute respiratory syndrome coronavirus 2 (MN908947)
Manually annotated by BRENDA team
Zhou, J.; Fang, L.; Yang, Z.; Xu, S.; Lv, M.; Sun, Z.; Chen, J.; Wang, D.; Gao, J.; Xiao, S.
Identification of novel proteolytically inactive mutations in coronavirus 3C-like protease using a combined approach
FASEB J.
33
14575-14587
2019
porcine epidemic diarrhea virus
Manually annotated by BRENDA team
Jo, S.; Kim, S.; Shin, D.H.; Kim, M.S.
Inhibition of SARS-CoV 3CL protease by flavonoids
J. Enzyme Inhib. Med. Chem.
35
145-151
2020
Severe acute respiratory syndrome-related coronavirus (P0C6X7)
Manually annotated by BRENDA team
Dong, S.; Sun, J.; Mao, Z.; Wang, L.; Lu, Y.L.; Li, J.
A guideline for homology modeling of the proteins from newly discovered betacoronavirus, 2019 novel coronavirus (2019-nCoV)
J. Med. Virol.
92
1542-1548
2020
Severe acute respiratory syndrome coronavirus 2 (MN908947), Severe acute respiratory syndrome coronavirus 2
Manually annotated by BRENDA team
Ton, A.T.; Gentile, F.; Hsing, M.; Ban, F.; Cherkasov, A.
Rapid identification of potential inhibitors of SARS-CoV-2 main protease by deep docking of 1.3 billion compounds
Mol. Inform.
39
e2000028
2020
Severe acute respiratory syndrome coronavirus 2 (MN908947), Severe acute respiratory syndrome coronavirus 2
Manually annotated by BRENDA team
Muramatsu, T.; Takemoto, C.; Kim, Y.T.; Wang, H.; Nishii, W.; Terada, T.; Shirouzu, M.; Yokoyama, S.
SARS-CoV 3CL protease cleaves its C-terminal autoprocessing site by novel subsite cooperativity
Proc. Natl. Acad. Sci. USA
113
12997-13002
2016
Severe acute respiratory syndrome-related coronavirus (P0C6X7), Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Lim, L.; Gupta, G.; Roy, A.; Kang, J.; Srivastava, S.; Shi, J.; Song, J.
Structurally- and dynamically-driven allostery of the chymotrypsin-like proteases of SARS, Dengue and Zika viruses
Prog. Biophys. Mol. Biol.
143
52-66
2019
Severe acute respiratory syndrome-related coronavirus (P0C6X7)
Manually annotated by BRENDA team
Li, C.; Teng, X.; Qi, Y.; Tang, B.; Shi, H.; Ma, X.; Lai, L.
Conformational flexibility of a short loop near the active site of the SARS-3CLpro is essential to maintain catalytic activity
Sci. Rep.
6
20918
2016
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Zhang, L.; Lin, D.; Sun, X.; Curth, U.; Drosten, C.; Sauerhering, L.; Becker, S.; Rox, K.; Hilgenfeld, R.
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved alpha-ketoamide inhibitors
Science
368
409-412
2020
Severe acute respiratory syndrome coronavirus 2 (MN908947), Severe acute respiratory syndrome coronavirus 2, Severe acute respiratory syndrome-related coronavirus (P0C6U8)
Manually annotated by BRENDA team
Perera, K.D.; Rathnayake, A.D.; Liu, H.; Pedersen, N.C.; Groutas, W.C.; Chang, K.O.; Kim, Y.
Characterization of amino acid substitutions in feline coronavirus 3C-like protease from a cat with feline infectious peritonitis treated with a protease inhibitor
Vet. Microbiol.
237
108398
2019
feline coronavirus
Manually annotated by BRENDA team
Kanitz, M.; Blanck, S.; Heine, A.; Gulyaeva, A.A.; Gorbalenya, A.E.; Ziebuhr, J.; Diederich, W.E.
Structural basis for catalysis and substrate specificity of a 3C-like cysteine protease from a mosquito mesonivirus
Virology
533
21-33
2019
Alphamesonivirus 1 (F8RL29)
Manually annotated by BRENDA team
Choudhury, M.; Dhanabalan, A.; Goswami, N.
Understanding the binding mechanism for potential inhibition of SARS-CoV-2 Mpro and exploring the modes of ACE2 inhibition by hydroxychloroquine
J. Cell. Biochem.
123
347-358
2021
Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
Manually annotated by BRENDA team
Cheng, Y.; Borum, R.; Clark, A.; Jin, Z.; Moore, C.; Fajtova, P.; ODonoghue, A.; Carlin, A.; Jokerst, J.
A dual-color fluorescent probe allows simultaneous imaging of main and papain-like proteases of SARS-CoV-2-infected cells for accurate detection and rapid inhibitor screening
Angew. Chem. Int. Ed. Engl.
61
e202113617
2022
Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
-
Manually annotated by BRENDA team
Chiou, W.; Chen, J.; Chen, Y.; Yang, J.; Hwang, L.; Lyu, Y.; Yang, H.; Huang, C.
The inhibitory effects of PGG and EGCG against the SARS-CoV-2 3C-like protease
Biochem. Biophys. Res. Commun.
591
130-136
2022
severe acute respiratory syndrome coronavirus (P0C6X7), Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Manually annotated by BRENDA team
Kankariya, R.A.; Chaudhari, A.B.; Dandi, N.D.
Inhibitory efficacy of 2, 4-diacetylphloroglucinol against SARS-COV-2 proteins in silico study
Biologia
2022
1-14
2022
Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
Manually annotated by BRENDA team
Gorai, S.; Junghare, V.; Kundu, K.; Gharui, S.; Kumar, M.; Patro, B.S.; Nayak, S.K.; Hazra, S.; Mula, S.
Synthesis of dihydrobenzofuro[3,2-b]chromenes as potential 3CLpro inhibitors of SARS-CoV-2 A molecular docking and molecular dynamics study
ChemMedChem
2022
e202100782
2022
Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
Manually annotated by BRENDA team
Alici, H.; Tahtaci, H.; Demir, K.
Design and various in silico studies of the novel curcumin derivatives as potential candidates against COVID-19-associated main enzymes
Comput. Biol. Chem.
98
107657
2022
Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
Manually annotated by BRENDA team
Stille, J.K.; Tjutrins, J.; Wang, G.; Venegas, F.A.; Hennecker, C.; Rueda, A.M.; Sharon, I.; Blaine, N.; Miron, C.E.; Pinus, S.; Labarre, A.; Plescia, J.; Burai Patrascu, M.; Zhang, X.; Wahba, A.S.; Vlaho, D.; Huot, M.J.; Schmeing, T.M.; Mittermaier, A.K.; Moitessier, N.
Design, synthesis and invitro evaluation of novel SARS-CoV-2 3CLpro covalent inhibitors
Eur. J. Med. Chem.
229
114046
2022
Severe acute respiratory syndrome coronavirus 2
Manually annotated by BRENDA team
Xiong, M.; Nie, T.; Shao, Q.; Li, M.; Su, H.; Xu, Y.
In silico screening-based discovery of novel covalent inhibitors of the SARS-CoV-2 3CL protease
Eur. J. Med. Chem.
231
114130
2022
Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
Manually annotated by BRENDA team
Kuo, C.J.; Liang, P.H.
SARS-CoV-2 3CLpro displays faster self-maturation in vitro than SARS-CoV 3CLpro due to faster C-terminal cleavage
FEBS Lett.
596
1214-1224
2022
severe acute respiratory syndrome coronavirus, Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
Manually annotated by BRENDA team
Bahun, M.; Jukic, M.; Oblak, D.; Kranjc, L.; Bajc, G.; Butala, M.; Bozovicar, K.; Bratkovic, T.; Podlipnik, C.; Poklar Ulrih, N.
Inhibition of the SARS-CoV-2 3CLpro main protease by plant polyphenols
Food Chem.
373
131594
2022
Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
Manually annotated by BRENDA team
Zhang, L.C.; Zhao, H.L.; Liu, J.; He, L.; Yu, R.L.; Kang, C.M.
Design of SARS-CoV-2 Mpro, PLpro dual-target inhibitors based on deep reinforcement learning and virtual screening
Future Med. Chem.
14
393-405
2022
Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
Manually annotated by BRENDA team
Chen, Y.; Yang, W.; Chen, H.; Huang, L.; Gao, J.; Lin, C.; Wang, Y.; Yang, C.; Liu, Y.; Hou, M.; Tsai, C.; Chou, Y.; Huang, B.; Hung, C.; Hung, Y.; Wang, W.; Su, W.; Kumar, V.; Wu, Y.; Chao, S.; Chang, C.; Chen, J.; Chiang, Y.; Cho, D.; Jeng, L.; Tsai, C.
Tafenoquine and its derivatives as inhibitors for the severe acute respiratory syndrome coronavirus 2
J. Biol. Chem.
298
101658
2022
Severe acute respiratory syndrome coronavirus 2
Manually annotated by BRENDA team
Bhargavi, S.; Madhan Shankar, S.R.; Jemmy, C.H.
In silico and in vitro studies on inhibitors for SARS-CoV-2 non-structural proteins with dual herbal combination of Withania somnifera with five rasayana herbs
J. Biomol. Struct. Dyn.
2022
1-16
2022
Severe acute respiratory syndrome coronavirus 2
Manually annotated by BRENDA team
De, P.; Bhayye, S.; Kumar, V.; Roy, K.
In silico modeling for quick prediction of inhibitory activity against 3CLpro enzyme in SARS CoV diseases
J. Biomol. Struct. Dyn.
40
1010-1036
2022
Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
Manually annotated by BRENDA team
Motiwale, M.; Yadav, N.; Kumar, S.; Kushwaha, T.; Choudhir, G.; Sharma, S.; Singour, P.
Finding potent inhibitors for COVID-19 main protease (Mpro) an in silico approach using SARS-CoV-3CL protease inhibitors for combating CORONA
J. Biomol. Struct. Dyn.
40
1534-1545
2022
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Manually annotated by BRENDA team
Swargiary, A.; Mahmud, S.; Saleh, M.
Screening of phytochemicals as potent inhibitor of 3-chymotrypsin and papain-like proteases of SARS-CoV2 an in silico approach to combat COVID-19
J. Biomol. Struct. Dyn.
40
2067-2081
2022
Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
Manually annotated by BRENDA team
Sharma, A.; Goyal, S.; Yadav, A.; Kumar, P.; Gupta, L.
In-silico screening of plant-derived antivirals against main protease, 3CLpro and endoribonuclease, NSP15 proteins of SARS-CoV-2
J. Biomol. Struct. Dyn.
40
86-100
2022
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Manually annotated by BRENDA team
Bhattacharya, K.; Bordoloi, R.; Chanu, N.R.; Kalita, R.; Sahariah, B.J.; Bhattacharjee, A.
In silico discovery of 3 novel quercetin derivatives against papain-like protease, spike protein, and 3C-like protease of SARS-CoV-2
J. Gen. Eng. Biotechnol.
20
43
2022
Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
Manually annotated by BRENDA team
Han, S.; Goins, C.; Arya, T.; Shin, W.; Maw, J.; Hooper, A.; Sonawane, D.; Porter, M.; Bannister, B.; Crouch, R.; Lindsey, A.; Lakatos, G.; Martinez, S.; Alvarado, J.; Akers, W.; Wang, N.; Jung, J.; MacDonald, J.; Stauffer, S.
Structure-based optimization of ML300-derived, noncovalent inhibitors targeting the severe acute respiratory syndrome coronavirus 3CL protease (SARS-CoV-2 3CLpro)
J. Med. Chem.
65
2880-2904
2022
severe acute respiratory syndrome coronavirus (P0C6X7), Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Manually annotated by BRENDA team
Wan, S.; Bhati, A.P.; Wade, A.D.; Alfe, D.; Coveney, PV
Thermodynamic and structural insights into the repurposing of drugs that bind to SARS-CoV-2 main protease
Mol. Syst. Des. Eng.
7
123-131
2021
Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
Manually annotated by BRENDA team
Phong, N.V.; Trang, N.M.; Quyen, C.T.; Anh, H.L.T.; Vinh, L.B.
SARS-CoV-2 main protease and papain-like protease inhibition by abietane-type diterpenes isolated from the branches of Glyptostrobus pensilis using molecular docking studies
Nat. Prod. Res.
2022
1-8
2022
Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
Manually annotated by BRENDA team
Tiyoula, F.T.; Aryapour, H.
Reconstruction of the unbinding pathways of noncovalent SARS-CoV and SARS-CoV-2 3CLpro inhibitors using unbiased molecular dynamics simulations
PLoS One
17
e0263251
2022
severe acute respiratory syndrome coronavirus (P0C6U8), Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
Manually annotated by BRENDA team
Abe, K.; Kabe, Y.; Uchiyama, S.; Iwasaki, Y.W.; Ishizu, H.; Uwamino, Y.; Takenouchi, T.; Uno, S.; Ishii, M.; Maruno, T.; Noda, M.; Murata, M.; Hasegawa, N.; Saya, H.; Kitagawa, Y.; Fukunaga, K.; Amagai, M.; Siomi, H.; Suematsu, M.; Kosaki, K.; Kosaki, K.
Pro108Ser mutation of SARS-CoV-2 3CLpro reduces the enzyme activity and ameliorates the clinical severity of COVID-19
Sci. Rep.
12
1299
2022
Severe acute respiratory syndrome coronavirus 2
Manually annotated by BRENDA team
Lewis, D.S.M.; Ho, J.; Wills, S.; Kawall, A.; Sharma, A.; Chavada, K.; Ebert, M.C.C.J.C.; Evoli, S.; Singh, A.; Rayalam, S.; Mody, V.; Taval, S.
Aloin isoforms (A and B) selectively inhibits proteolytic and deubiquitinating activity of papain like protease (PLpro) of SARS-CoV-2 in vitro
Sci. Rep.
12
2145
2022
Severe acute respiratory syndrome coronavirus 2
Manually annotated by BRENDA team
Mathpal, S.; Joshi, T.; Sharma, P.; Pande, V.; Chandra, S.
Assessment of activity of chalcone compounds as inhibitors of 3-chymotrypsin like protease (3CLPro) of SARS-CoV-2 in silico study
Struct. Chem.
2022
1-17
2022
Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
Manually annotated by BRENDA team